gene

GAPDH

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GAPDH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1395Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

GAPDH is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, inhibits. Associated with ALS, Aging, Als. Connected to 581 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	GAPDH
Full Name	Glyceraldehyde-3-Phosphate Dehydrogenase
Chromosome	12p13.31
Protein Type	Enzyme
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	37 kDa
Pathways	Akt, Apoptosis, Autophagy, Cell Cycle, Chaperone
UniProt ID	P04406
NCBI Gene ID	2597
Ensembl ID	ENSG00000111640
OMIM	138400
GeneCards	GAPDH
Human Protein Atlas	GAPDH
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Ataxia
Known Drugs/Compounds	5-HT, dimethyl fumarate, levodopa, rapamycin, RAPAMYCIN, Vitamin C
Interactions	ABP, ACAT1, ACTB, ACTG1, AGING, AIF1
KG Connections	1395 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GAPDH — AlphaFold P04406 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

GAPDH Gene

gene · 753 words

→

GAPDH Protein

protein · 1196 words

→

Pathway Diagram

flowchart TD
    GAPDH(["GAPDH"])
    Als["Als"]
    glycolysis["glycolysis"]
    IFN_gamma_mRNA(["IFN-gamma mRNA"])
    IFN_gamma(["IFN-gamma"])
    Glycolysis["Glycolysis"]
    Neurodegeneration["Neurodegeneration"]
    Parkinson["Parkinson"]
    Cancer["Cancer"]
    Tumor["Tumor"]
    Aging["Aging"]
    Mtor["Mtor"]

    GAPDH -->|"activates"| Als
    GAPDH -->|"participates in"| glycolysis
    GAPDH -->|"interacts with"| IFN_gamma_mRNA
    GAPDH -->|"regulates"| IFN_gamma
    glycolysis -->|"regulates"| GAPDH
    GAPDH -->|"regulates"| Glycolysis
    GAPDH -->|"activates"| Neurodegeneration
    GAPDH -->|"associated with"| Parkinson
    GAPDH -->|"regulates"| Cancer
    GAPDH -->|"regulates"| Tumor
    GAPDH -.->|"inhibits"| Neurodegeneration
    GAPDH -->|"regulates"| Aging
    GAPDH -->|"activates"| Aging
    GAPDH -->|"therapeutic target"| Cancer
    GAPDH -->|"associated with"| Mtor

    style GAPDH fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (928)

Target	Relation	Type	Str
Als	activates	disease	1.00
neural stem cells	activates	cell_type	0.90
Glycolysis	associated_with	pathway	0.90
glycolysis	participates_in	pathway	0.90
IFN-gamma mRNA	interacts_with	protein	0.90
IFN-gamma	regulates	protein	0.90
energetic crisis	causes	pathway	0.85
Vitamin C	inhibits	compound	0.85
CD8+ T cells	expresses	cell_type	0.80
TGM2	interacts_with	protein	0.80
5-HT	interacts_with	compound	0.80
LC3	regulates	gene	0.80
glycolytic metabolism	regulates	pathway	0.80
apoptosis pathway	participates_in	pathway	0.80
RNA	activates	gene	0.80
neural stem cells	regulates	cell_type	0.80
ubiquitin-proteasome	participates_in	pathway	0.80
MAP1LC3	regulates	gene	0.80
oxidative stress response	participates_in	pathway	0.80
Psoriasis	associated_with	disease	0.80
RAPAMYCIN	activates	drug	0.80
Glycolysis	regulates	pathway	0.80
Cancer	therapeutic_target	disease	0.75
Aging	activates	disease	0.75
Aging	regulates	disease	0.75
breast cancer	markers	disease	0.75
Neurodegeneration	activates	disease	0.75
Parkinson	associated_with	disease	0.75
Neurodegeneration	inhibits	disease	0.75
Cancer	regulates	disease	0.75
Tumor	regulates	disease	0.75
MTOR	associated_with	gene	0.70
Mtor	associated_with	pathway	0.70
neural stem cells	interacts_with	cell_type	0.70
LC3B	activates	gene	0.70
epigenetic regulation	participates_in	pathway	0.70
RNA	regulates	gene	0.70
autophagy pathway	participates_in	pathway	0.70
Parkinson's disease	regulates	disease	0.70
stem cells	expressed_in	cell_type	0.70
neurons	activates	cell_type	0.70
Wnt signaling	participates_in	pathway	0.70
Parkinson's disease	activates	disease	0.70
Oxidative Stress	activates	pathway	0.70
adenosine	activates	neurotransmitter	0.70
antitumor immunity	enhances	pathway	0.70
breast cancer	associated_with	disease	0.70
CANCER	regulates	gene	0.70
Alzheimer's disease	associated_with	disease	0.70
ULK1	regulates	gene	0.70

Incoming (467)

Source	Relation	Type	Str
AUTOPHAGY	activates	process	0.95
rapamycin	targets	drug	0.90
Serotonin	modulates	compound	0.90
glycolysis	regulates	pathway	0.80
ATG	activates	gene	0.80
CALCOCO2	regulates	gene	0.70
AMPK	regulates	gene	0.70
CTSB	interacts_with	gene	0.70
ATG	regulates	gene	0.70
AUTOPHAGY	associated_with	gene	0.70
OXIDATIVE STRESS	activates	gene	0.70
AKT1	targets	gene	0.70
AR	activates	gene	0.70
NEURODEGENERATION	activates	gene	0.70
AIF1	regulates	gene	0.60
CBP	activates	gene	0.60
FKBP5	activates	gene	0.60
FKBP5	regulates	gene	0.60
CTSD	activates	gene	0.60
ATM	activates	gene	0.60
ATG5	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
dimethyl fumarate	activates	compound	0.60
BCL2	regulates	gene	0.60
dimethyl fumarate	regulates	compound	0.60
OXIDATIVE STRESS	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
CAT	activates	gene	0.60
CDKN1A	activates	gene	0.60
CYCS	activates	gene	0.60
ABP	activates	gene	0.60
ATG16L1	activates	gene	0.60
CDK2	targets	gene	0.60
ATR	activates	gene	0.60
DYNLL1	activates	gene	0.60
EIF4EBP1	activates	gene	0.60
DEPTOR	regulates	gene	0.60
CREBBP	interacts_with	gene	0.60
EP300	interacts_with	gene	0.60
CSNK1A1	associated_with	gene	0.60
AGING	associated_with	gene	0.60
ASC	regulates	gene	0.60
CDC42	activates	gene	0.60
CYTOKINES	therapeutic_target	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
TNF-Α	therapeutic_target	gene	0.60
IL-6	associated_with	gene	0.60
NFKB	regulates	gene	0.60
ERBB2	regulates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Metabolic Reprogramming Toward GAPDH Inhibition	0.450	neurodegeneration	How does controlled lysosomal membrane p

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GAPDH in their description or question text

No additional research found