gene

NPY1R

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NPY1R: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

106Connections

0Hypotheses

0Analyses

50Outgoing

41Incoming

0Experiments

0Debates

Summary

Neuropeptide Y Receptor Y1 - GPCR implicated in feeding, mood, epilepsy, and Alzheimer's disease

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🧬 Gene Info

Gene Symbol	NPY1R
Aliases	Neuropeptide Y Receptor Y1
Function	is a Class A rhodopsin-family GPCR that plays critical roles in regulating feeding behavior, energy homeostasis, emotional responses, synaptic plasticity, and seizure threshold [1](https://pubmed.
Primary Expression	brain regions involved in energy homeostasis, emotional processing, and memory:
Amino Acids	384 aa
Pathways	MAPK pathway
Ensembl ID	ENSG00000118322
GeneCards	NPY1R
Human Protein Atlas	NPY1R
BIBP3226	First selective non-peptide antagonist
NPY 3-36	Y1 antagonist (prefers Y2/Y5)
Leu^31-Pro^34]-NPY	Y1 agonist
Associated Diseases	Als, Asthma
Interactions	Albumin, INFLAMMATION, NPY
KG Connections	101 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NPY1R Gene

gene · 1930 words

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Pathway Diagram

graph TD
    NPY1R["NPY1R"]
    Als{"Als"}
    NPY1R -->|"associated with"| Als
    Ms{"Ms"}
    NPY1R -->|"contributes to"| Ms
    Inflammation{"Inflammation"}
    NPY1R -->|"activates"| Inflammation
    NPY["NPY"]
    NPY1R -->|"activates"| NPY
    BDNF["BDNF"]
    NPY1R -->|"contributes to"| BDNF
    STAT6["STAT6"]
    NPY1R -->|"associated with"| STAT6
    JAK["JAK"]
    NPY1R -->|"associated with"| JAK
    AND["AND"]
    NPY1R -->|"contributes to"| AND
    CYTOKINES["CYTOKINES"]
    NPY1R -->|"contributes to"| CYTOKINES
    INFLAMMATION["INFLAMMATION"]
    NPY1R -->|"activates"| INFLAMMATION
    neurodegeneration["neurodegeneration"]
    NPY1R -->|"implicated in"| neurodegeneration
    JAK -->|"associated with"| NPY1R
    CYTOKINES -->|"contributes to"| NPY1R
    INFLAMMATION -->|"activates"| NPY1R
    NPY -->|"activates"| NPY1R
    style NPY1R fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (65)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:NPY1R	data_in	dataset_row	0.00
nociceptor excitability	inhibits	phenotype	0.80
Asthma	associated_with	disease	0.65
Als	causes	disease	0.65
Als	associated_with	disease	0.65
Ms	contributes_to	disease	0.65
Inflammation	activates	disease	0.65
ALS	causes	disease	0.65
JAK	associated_with	gene	0.60
INFLAMMATION	activates	gene	0.60
STAT6	associated_with	gene	0.60
CYTOKINES	contributes_to	gene	0.60
Il-1	causes	protein	0.60
NPY	activates	gene	0.60
BDNF	contributes_to	gene	0.60
LITAF	regulates	gene	0.60
NFKBIA	regulates	gene	0.60
SESN1	regulates	gene	0.60
PDK4	regulates	gene	0.60
MYH2	regulates	gene	0.60
CDKN1A	regulates	gene	0.60
JUN	regulates	gene	0.60
NDRG2	regulates	gene	0.60
CALM2	regulates	gene	0.60
SOX2	regulates	gene	0.60
DUSP1	regulates	gene	0.60
MERTK	regulates	gene	0.60
IRF1	regulates	gene	0.60
Autophagy	regulates	pathway	0.60
Mtor	regulates	pathway	0.60
Immune Response	regulates	pathway	0.60
IL-13	causes	gene	0.60
CYTOKINES	causes	gene	0.60
Neuron	activates	cell_type	0.60
SOX9	regulates	gene	0.60
VPS37B	regulates	gene	0.60
ADRA1D	regulates	gene	0.60
PPP5C	regulates	gene	0.60
ADCY9	regulates	gene	0.60
Nfkb	regulates	protein	0.60
JAK	causes	gene	0.60
STAT6	causes	gene	0.60
IL6R	regulates	gene	0.60
RNA	causes	gene	0.60
IL-1	causes	gene	0.60
Albumin	activates	protein	0.60
Bdnf	causes	protein	0.60
Interleukin	causes	protein	0.60
Cytokine	causes	protein	0.60
Actin	regulates	protein	0.60

Incoming (41)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:NPY1R	data_in	dataset_row	0.00
IL-13	upregulates	protein	0.85
JAK/STAT6	activates	pathway	0.82
BDNF	upregulates	protein	0.75
JUN	regulates	gene	0.60
ADRA1D	regulates	gene	0.60
PDK4	regulates	gene	0.60
LITAF	regulates	gene	0.60
IL6R	regulates	gene	0.60
MERTK	regulates	gene	0.60
DUSP1	regulates	gene	0.60
ADCY9	regulates	gene	0.60
SOX2	regulates	gene	0.60
CDKN1A	regulates	gene	0.60
SESN1	regulates	gene	0.60
IRF1	regulates	gene	0.60
NDRG2	regulates	gene	0.60
SOX9	regulates	gene	0.60
MYH2	regulates	gene	0.60
VPS37B	regulates	gene	0.60
NFKBIA	regulates	gene	0.60
CALM2	regulates	gene	0.60
STAT6	causes	gene	0.60
JAK	associated_with	gene	0.60
CYTOKINES	contributes_to	gene	0.60
INFLAMMATION	activates	gene	0.60
CCND1	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
MTORC1	regulates	gene	0.60
TSC22D3	regulates	gene	0.60
IL-1	causes	gene	0.60
RNA	causes	gene	0.60
IL-13	causes	gene	0.60
PPP5C	regulates	gene	0.60
CYTOKINES	causes	gene	0.60
NPY	activates	gene	0.60
AND	causes	gene	0.60
BDNF	causes	gene	0.60
adcy9	regulates	gene	0.50
adra1d	regulates	gene	0.50
Autophagy	regulates	process	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NPY1R in their description or question text

No additional research found