concept

GFP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GFP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1015Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

GFP is a concept in neurodegeneration research. Key relationships include: associated with, activates, inhibits. Associated with AD, ALI, ALS. Connected to 429 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	GFP
Key Genes/Proteins	ABL1, ABP, ACETYL-COA, ACLY, ACTB, Actin
Related Diseases	AD, Aging, ALI, Als
Related Pathways	Akt

Pathway Diagram

graph TD
    GFP["GFP"]
    GFP -->|"expressed in"| microglia["microglia"]
    GFP -->|"interacts"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    GFP -->|"interacts"| ALS["ALS"]
    GFP -->|"interacts"| Dementia["Dementia"]
    GFP -->|"activates"| Tumor["Tumor"]
    GFP -->|"degrades"| Aging["Aging"]
    GFP -->|"degrades"| Cardiovascular["Cardiovascular"]
    GFP -->|"inhibits"| Inflammation["Inflammation"]
    C9ORF72["C9ORF72"] -->|"interacts"| GFP
    LC3["LC3"] -->|"interacts"| GFP
    P62["P62"] -->|"interacts"| GFP
    FUS["FUS"] -->|"interacts"| GFP
    UBIQUITIN["UBIQUITIN"] -->|"interacts"| GFP
    SQSTM1["SQSTM1"] -->|"interacts"| GFP
    TRIM21["TRIM21"] -->|"interacts"| GFP
    OPTN["OPTN"] -->|"interacts"| GFP
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"] -->|"regulates"| GFP
    ACTB["ACTB"] -->|"interacts"| GFP

Outgoing (703)

Target	Relation	Type	Str
AUTOPHAGY	activates	gene	1.00
LC3	associated_with	gene	1.00
Autophagy	activates	pathway	1.00
Autophagy	associated_with	pathway	1.00
AUTOPHAGY	associated_with	gene	1.00
MTOR	activates	gene	1.00
Mtor	activates	pathway	1.00
Tumor	activates	disease	0.95
oxidative stress response	participates_in	pathway	0.90
autophagy pathway	participates_in	pathway	0.90
AKT	activates	gene	0.90
Infection	activates	disease	0.85
Aging	inhibits	disease	0.85
Als	activates	disease	0.85
neural stem cells	activates	cell_type	0.80
MCOLN1	activates	gene	0.80
apoptosis pathway	participates_in	pathway	0.80
neurons	regulates	cell_type	0.80
ubiquitin-proteasome	participates_in	pathway	0.80
Apoptosis	associated_with	pathway	0.80
Pi3K/Akt	activates	pathway	0.80
Mtor	associated_with	pathway	0.80
PI3K	activates	gene	0.80
AMPK	activates	gene	0.80
Apoptosis	activates	pathway	0.80
LC3	activates	gene	0.80
APOPTOSIS	activates	gene	0.80
Tumor	inhibits	disease	0.75
Inflammation	activates	disease	0.75
Cancer	associated_with	disease	0.75
Als	associated_with	disease	0.75
Cancer	therapeutic_target	disease	0.75
Autophagy	therapeutic_target	pathway	0.70
Apoptosis	therapeutic_target	pathway	0.70
CANCER	therapeutic_target	gene	0.70
Mtor	inhibits	pathway	0.70
GENES	therapeutic_target	gene	0.70
AUTOPHAGY	therapeutic_target	gene	0.70
APOPTOSIS	therapeutic_target	gene	0.70
MITOPHAGY	activates	gene	0.70
DMSO	associated_with	gene	0.70
Mitophagy	activates	pathway	0.70
BECN1	associated_with	gene	0.70
P62	associated_with	gene	0.70
ATG5	activates	gene	0.70
neurons	disrupts	cell_type	0.70
RNA	regulates	gene	0.70
adenosine	activates	neurotransmitter	0.70
NBR1	regulates	gene	0.70
SQSTM1	regulates	gene	0.70

Incoming (312)

Source	Relation	Type	Str
rapamycin	targets	drug	0.80
CTSD	activates	gene	0.70
AMPK	interacts_with	gene	0.70
CTSD	interacts_with	gene	0.70
CASP3	activates	gene	0.70
CTSB	activates	gene	0.70
CTSB	interacts_with	gene	0.70
CALCOCO2	regulates	gene	0.70
SQSTM1	associated_with	gene	0.70
BECN1	associated_with	gene	0.70
DNA	activates	gene	0.70
BECN1	activates	gene	0.70
AIF1	associated_with	gene	0.60
PARKINSON	inhibits	gene	0.60
SQSTM1	inhibits	gene	0.60
NEURODEGENERATIVE DISORDERS	inhibits	gene	0.60
NEURODEGENERATIVE DISEASES	inhibits	gene	0.60
ACTB	associated_with	gene	0.60
GFAP	associated_with	gene	0.60
INFLAMMATION	inhibits	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
TNF	inhibits	gene	0.60
ATG5	associated_with	gene	0.60
IL1B	inhibits	gene	0.60
LC3B	inhibits	gene	0.60
AGING	inhibits	gene	0.60
ASC	inhibits	gene	0.60
SMCR8	interacts_with	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
MAP1LC3	interacts_with	gene	0.60
DEMENTIA	interacts_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	gene	0.60
RAS	associated_with	gene	0.60
TCF4	associated_with	gene	0.60
AUTOPHAGY	regulates	gene	0.60
AXIN	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
AXIN2	associated_with	gene	0.60
BCL2L13	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
ATG7	associated_with	gene	0.60
BRAIN INJURY	degrades	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
PNPLA6	associated_with	gene	0.60
WNT	associated_with	gene	0.60
EEA1	associated_with	gene	0.60
ACTB	activates	gene	0.60
ALS	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GFP in their description or question text

No additional research found