gene

SOX9

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SOX9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

364Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

SRY-Box Transcription Factor 9 involved in chondrogenesis, neural crest development, glial differentiation, and neurodegenerative disease pathogenesis

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🧬 Gene Info

Gene Symbol	SOX9
Full Name	SRY-Box Transcription Factor 9
Chromosome	17q24.3
Protein Family	SOX family (Sry-related HMG box)
Protein Type	Transcription Factor
Function	encodes a high-mobility-group (HMG) box transcription factor essential for chondrogenesis, neural crest development, sex determination, and glial cell differentiation.
Subcellular Localization	Nucleus
Molecular Weight	56 kDa
Amino Acids	509 aa
Gene Type	Protein coding
Pathways	Apoptosis, Autophagy, Cell Cycle, Epigenetic, Hedgehog
UniProt ID	P48436
NCBI Gene ID	6662
Ensembl ID	ENSG00000125398
OMIM	608161
GeneCards	SOX9
Human Protein Atlas	SOX9
Associated Diseases	Cancer, Cardiovascular, Ischemia, Ms, Neurodegeneration, Parkinson
Known Drugs/Compounds	rapamycin
Interactions	ACTB, Actin, ACVR1, AGING, AKT, AMPK
KG Connections	364 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SOX9 — AlphaFold P48436 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SOX9 Gene

gene · 1635 words

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Pathway Diagram

flowchart TD
    SOX9["SOX9
Transcription Factor"]
    
    %% Autophagy pathway
    BECN1["BECN1
Autophagy Initiator"]
    MAP1LC3B["MAP1LC3B
Autophagosome Formation"]
    PIK3C3["PIK3C3
PI3K Complex"]
    UVRAG["UVRAG
Autophagy Regulator"]
    MTOR["MTOR
Autophagy Inhibitor"]
    
    %% Alzheimer's pathway
    APP["APP
Amyloid Precursor"]
    PSEN1["PSEN1
Gamma Secretase"]
    Amyloid_Plaques["Amyloid Plaques
Pathological Aggregates"]
    
    %% Epigenetic regulation
    HDAC6["HDAC6
Histone Deacetylase"]
    
    %% Neurodegeneration outcomes
    Alzheimer["Alzheimer's Disease
Cognitive Decline"]
    Parkinson["Parkinson's Disease
Motor Dysfunction"]
    ALS["ALS
Motor Neuron Death"]
    MS["Multiple Sclerosis
Demyelination"]
    
    %% Cellular processes
    Neuronal_Survival["Neuronal Survival
Neuroprotection"]
    Autophagy_Process["Autophagy Process
Protein Clearance"]
    
    %% Connections
    SOX9 -->|"regulates"| BECN1
    SOX9 -->|"associates"| MAP1LC3B
    SOX9 -->|"associates"| PIK3C3
    SOX9 -->|"associates"| UVRAG
    SOX9 -->|"associates"| MTOR
    SOX9 -->|"associates"| HDAC6
    
    BECN1 -->|"initiates"| Autophagy_Process
    MAP1LC3B -->|"forms"| Autophagy_Process
    PIK3C3 -->|"supports"| Autophagy_Process
    UVRAG -->|"regulates"| Autophagy_Process
    MTOR -->|"inhibits"| Autophagy_Process
    
    SOX9 -->|"associates"| APP
    SOX9 -->|"associates"| PSEN1
    APP -->|"processed_by"| PSEN1
    PSEN1 -->|"generates"| Amyloid_Plaques
    
    SOX9 -->|"therapeutic_target"| Alzheimer
    SOX9 -->|"associated_with"| Parkinson
    SOX9 -->|"inhibits"| ALS
    SOX9 -->|"associated_with"| MS
    
    Autophagy_Process -->|"promotes"| Neuronal_Survival
    Amyloid_Plaques -->|"causes"| Alzheimer
    HDAC6 -->|"regulates"| Neuronal_Survival
    
    style SOX9 fill:#006494
    style Neuronal_Survival fill:#1b5e20
    style Autophagy_Process fill:#1b5e20
    style Alzheimer fill:#ef5350
    style Parkinson fill:#ef5350
    style ALS fill:#ef5350
    style MS fill:#ef5350
    style Amyloid_Plaques fill:#ef5350
    style BECN1 fill:#4a1a6b
    style MTOR fill:#4a1a6b
    style HDAC6 fill:#4a1a6b
    style PSEN1 fill:#4a1a6b

Outgoing (208)

Target	Relation	Type	Str
Chondrogenesis	associated_with	process	0.80
Als	activates	disease	0.75
Als	regulates	disease	0.65
Als	inhibits	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Arthritis	inhibits	disease	0.65
Diabetes	regulates	disease	0.65
ALS	activates	disease	0.65
Aging	inhibits	disease	0.65
Liver Cancer	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Carcinoma	activates	disease	0.65
Inflammation	activates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Cardiovascular	regulates	disease	0.65
Cancer	regulates	disease	0.65
Cancer	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Ischemia	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Cancer	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
TSC22D3	regulates	gene	0.60
Autophagy	regulates	pathway	0.60
Mtor	regulates	pathway	0.60
Immune Response	regulates	pathway	0.60
Cell Cycle	regulates	pathway	0.60
Actin	activates	protein	0.60
INFLAMMATION	activates	gene	0.60
YTHDF2	activates	gene	0.60
AND	inhibits	gene	0.60
SLC7A11	activates	gene	0.60
MMP1	activates	gene	0.60
FER	activates	gene	0.60
GPX4	activates	gene	0.60
GABARAP	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
FYCO1	associated_with	gene	0.60
LAMP2	associated_with	gene	0.60
PSEN2	associated_with	gene	0.60
GLA	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
BCL2L1	associated_with	gene	0.60
TFEB	activates	entity	0.60

Incoming (156)

Source	Relation	Type	Str
circEHD2	upstream_of	gene	0.95
SIRT1	activates	gene	0.60
NLRP3	activates	gene	0.60
PPP5C	regulates	gene	0.60
JUN	activates	gene	0.60
ADRA1D	regulates	gene	0.60
PDK4	regulates	gene	0.60
LITAF	activates	gene	0.60
IL6R	regulates	gene	0.60
MERTK	regulates	gene	0.60
DUSP1	regulates	gene	0.60
ADCY9	regulates	gene	0.60
SOX2	activates	gene	0.60
CDKN1A	regulates	gene	0.60
SESN1	regulates	gene	0.60
IRF1	activates	gene	0.60
NDRG2	regulates	gene	0.60
ACVR1	activates	gene	0.60
NPY1R	regulates	gene	0.60
VPS37B	regulates	gene	0.60
NFKBIA	activates	gene	0.60
MYH2	regulates	gene	0.60
CALM2	regulates	gene	0.60
MMP3	regulates	entity	0.60
GPX4	inhibits	gene	0.60
MMP1	activates	gene	0.60
PTEN	regulates	gene	0.60
PSEN1	associated_with	gene	0.60
WDR45	associated_with	gene	0.60
MMP1	regulates	entity	0.60
AR	activates	gene	0.60
BCL2	activates	gene	0.60
CASP3	activates	gene	0.60
CLU	activates	gene	0.60
IL6	activates	gene	0.60
ACTB	activates	gene	0.60
CTSB	activates	gene	0.60
EIF4EBP1	activates	gene	0.60
GUSB	activates	gene	0.60
HEXB	activates	gene	0.60
LC3	activates	gene	0.60
LGALS3	activates	gene	0.60
LRP2	activates	gene	0.60
MCOLN1	activates	gene	0.60
ATG	associated_with	gene	0.60
PRESENILIN	associated_with	gene	0.60
CYTOKINES	activates	gene	0.60
RAS	associated_with	gene	0.60
CYP19A1	associated_with	gene	0.60
RNA	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SOX9 in their description or question text

No additional research found