gene

LITAF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LITAF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

75Connections

0Hypotheses

0Analyses

44Outgoing

31Incoming

0Experiments

0Debates

Summary

Gene page for LITAF encoding a lysosomal protein involved in peripheral neuropathy and inflammation

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🧬 Gene Info

Gene Symbol	LITAF
Full Name	Lipopolysaccharide-Induced Tumor Necrosis Factor Factor
Aliases	SIMPLE, CMT1C
Chromosome	16p13.13
Function	The protein contains several functional domains
Subcellular Localization	the lysosomal membrane and late endosome compartments. The protein contains several functional domains:
Molecular Weight	17 kDa
Amino Acids	161 aa
Pathways	Autophagy, Cell Cycle, Immune Response, Mtor
UniProt ID	Q9Y5K2
NCBI Gene ID	10868
Ensembl ID	ENSG00000106789
OMIM	604577
GeneCards	LITAF
Human Protein Atlas	LITAF
Associated Diseases	ALS, Alzheimer's disease, frontotemporal dementia
Interactions	AND, GENES, IL18, IRF1, JUN, Nfkb
KG Connections	75 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: LITAF — AlphaFold Q9Y5K2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

LITAF — Lipopolysaccharide-Induced Tumor Necrosis Factor Factor

gene · 1116 words

→

LITAF Protein

protein · 605 words

→

Pathway Diagram

graph TD
    LITAF["LITAF"]
    Ms{"Ms"}
    LITAF -->|"activates"| Ms
    Tumor{"Tumor"}
    LITAF -->|"activates"| Tumor
    Atherosclerosis{"Atherosclerosis"}
    LITAF -->|"activates"| Atherosclerosis
    TNF__["TNF-Alpha"]
    LITAF -->|"activates"| TNF__
    Mapk(["Mapk"])
    LITAF -->|"activates"| Mapk
    Necroptosis(["Necroptosis"])
    LITAF -->|"activates"| Necroptosis
    neurodegeneration["neurodegeneration"]
    LITAF -->|"implicated in"| neurodegeneration
    VEGF["VEGF"]
    VEGF -->|"activates"| LITAF
    IL18["IL18"]
    IL18 -->|"activates"| LITAF
    TNF["TNF"]
    TNF -->|"activates"| LITAF
    P38["P38"]
    P38 -->|"activates"| LITAF
    style LITAF fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (44)

Target	Relation	Type	Str
Atherosclerosis	activates	disease	0.65
Ms	activates	disease	0.65
Tumor	activates	disease	0.65
TSC22D3	regulates	gene	0.60
Autophagy	regulates	pathway	0.60
Mtor	regulates	pathway	0.60
Immune Response	regulates	pathway	0.60
AND	activates	gene	0.60
GENES	activates	gene	0.60
HDC	regulates	gene	0.60
Cell Cycle	regulates	pathway	0.60
Actin	regulates	protein	0.60
ALS	associated_with	disease	0.60
Alzheimer's disease	associated_with	disease	0.60
frontotemporal dementia	associated_with	disease	0.60
oxidative stress response	participates_in	pathway	0.60
IL6R	regulates	gene	0.60
MERTK	regulates	gene	0.60
DUSP1	regulates	gene	0.60
ADCY9	regulates	gene	0.60
SOX2	activates	gene	0.60
CDKN1A	regulates	gene	0.60
SESN1	regulates	gene	0.60
IRF1	activates	gene	0.60
NDRG2	regulates	gene	0.60
SOX9	activates	gene	0.60
MYH2	regulates	gene	0.60
VPS37B	regulates	gene	0.60
NFKBIA	activates	gene	0.60
CALM2	regulates	gene	0.60
NPY1R	regulates	gene	0.60
PDK4	regulates	gene	0.60
JUN	activates	gene	0.60
ADRA1D	regulates	gene	0.60
Nfkb	activates	protein	0.60
OPTN	associated_with	gene	0.60
POLG	associated_with	gene	0.60
TBK1	associated_with	gene	0.60
TNF-Α	activates	gene	0.60
Mapk	activates	pathway	0.60
CCND1	regulates	gene	0.60
Necroptosis	activates	pathway	0.60
AUTOPHAGY	regulates	gene	0.60
MTORC1	regulates	gene	0.60

Incoming (31)

Source	Relation	Type	Str
CCND1	regulates	gene	0.60
MTORC1	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
TSC22D3	regulates	gene	0.60
HDC	regulates	gene	0.60
CALM2	regulates	gene	0.60
SOX9	activates	gene	0.60
CDKN1A	regulates	gene	0.60
SESN1	regulates	gene	0.60
MYH2	regulates	gene	0.60
NDRG2	regulates	gene	0.60
VEGF	activates	gene	0.60
IL18	activates	gene	0.60
TNF	activates	gene	0.60
P38	activates	gene	0.60
ALS4	associated_with	gene	0.60
APP	associated_with	gene	0.60
CAPN1	associated_with	gene	0.60
MERTK	regulates	gene	0.60
JUN	activates	gene	0.60
ADRA1D	regulates	gene	0.60
PDK4	regulates	gene	0.60
IL6R	regulates	gene	0.60
ADCY9	regulates	gene	0.60
NPY1R	regulates	gene	0.60
DUSP1	regulates	gene	0.60
VPS37B	regulates	gene	0.60
PPP5C	regulates	gene	0.60
SOX2	activates	gene	0.50
NFKBIA	activates	gene	0.50
IRF1	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LITAF in their description or question text

No additional research found