gene

MERTK

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MERTK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

254Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

MER Proto-Oncogene, Tyrosine Kinase: receptor tyrosine kinase in TAM family involved in microglial phagocytosis and neurodegeneration

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🧬 Gene Info

Gene Symbol	MERTK
Full Name	MERTK - MER Tyrosine Kinase
Aliases	Page for MERTK Protein
Chromosome	2q14.1
Protein Type	Gene
Primary Expression	macrophages, microglia, photoreceptor cells, and neurons, where it mediates the clearance of apoptotic cells and cellular debris through recognition o
Molecular Weight	110 kDa
Amino Acids	998 aa
Exons	20
Pathways	NF-κB, PI3K, MAPK
UniProt ID	Q12866
NCBI Gene ID	10488
Ensembl ID	ENSG00000153208
GeneCards	MERTK
Human Protein Atlas	MERTK
Associated Diseases	Aging, Alzheimer, Diabetes, Fibrosis, Hepatitis, Infection
Interactions	ADAM8, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, Amyloid-Beta
KG Connections	254 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure Comparison — MERTK Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

3TCP — X-ray / Cryo-EM

🔮 AI Predicted Structure

Q12866 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

MERTK - MER Tyrosine Kinase

gene · 2621 words

→

MERTK Protein - MER Tyrosine Kinase

protein · 735 words

→

Pathway Diagram

graph TD
    MERTK["MERTK"]
    Neuroinflammation{"Neuroinflammation"}
    MERTK -->|"expressed in"| Neuroinflammation
    Ms{"Ms"}
    MERTK -->|"expressed in"| Ms
    Inflammation{"Inflammation"}
    MERTK -->|"regulates"| Inflammation
    Lymphoma{"Lymphoma"}
    MERTK -->|"activates"| Lymphoma
    MERTK -->|"activates"| Ms
    Atherosclerosis{"Atherosclerosis"}
    MERTK -->|"activates"| Atherosclerosis
    ERK["ERK"]
    MERTK -->|"expressed in"| ERK
    AKT["AKT"]
    MERTK -->|"activates"| AKT
    APOPTOSIS["APOPTOSIS"]
    MERTK -->|"activates"| APOPTOSIS
    MAF["MAF"]
    MERTK -->|"activates"| MAF
    Akt(["Akt"])
    MERTK -->|"activates"| Akt
    Apoptosis(["Apoptosis"])
    MERTK -->|"activates"| Apoptosis
    STAT6["STAT6"]
    STAT6 -->|"expressed in"| MERTK
    EPHA4["EPHA4"]
    EPHA4 -->|"expressed in"| MERTK
    MTOR["MTOR"]
    MTOR -->|"activates"| MERTK
    ASTROCYTES["ASTROCYTES"]
    ASTROCYTES -->|"expressed in"| MERTK
    ERK -->|"expressed in"| MERTK
    style MERTK fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (159)

Target	Relation	Type	Str
Efferocytosis	mediates	process	0.85
Apoptosis	activates	pathway	0.70
Ms	activates	disease	0.65
Cancer	activates	disease	0.65
Atherosclerosis	activates	disease	0.65
ALS	activates	disease	0.65
Lymphoma	activates	disease	0.65
MICROGLIA	treats	cell_type	0.65
Ms	expressed_in	disease	0.65
Inflammation	regulates	disease	0.65
Alzheimer	activates	disease	0.65
Als	activates	disease	0.65
Aging	associated_with	disease	0.65
Als	regulates	disease	0.65
Senescence	associated_with	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Alzheimer	associated_with	disease	0.65
Cardiac	activates	disease	0.65
Carcinoma	activates	disease	0.65
Sepsis	activates	disease	0.65
Inflammation	activates	disease	0.65
Infection	implicated_in	disease	0.65
Fibrosis	implicated_in	disease	0.65
Hepatitis	implicated_in	disease	0.65
Diabetes	implicated_in	disease	0.65
ALS	regulates	disease	0.65
MAF	activates	gene	0.60
GFAP	expressed_in	gene	0.60
ALDH1L1	expressed_in	gene	0.60
STAT6	expressed_in	gene	0.60
C1QB	regulates	gene	0.60
SIRPA	regulates	gene	0.60
C1S	regulates	gene	0.60
GPR109A	activates	gene	0.60
TREM2	activates	gene	0.60
phagocytosis	activates	process	0.60
MS4A6A	implicated_in	gene	0.60
SYK	implicated_in	gene	0.60
MS4A6A	associated_with	gene	0.60
SYK	associated_with	gene	0.60
neurodegeneration	regulates	disease	0.60
LDL	activates	gene	0.60
IL-10	activates	gene	0.60
Macrophage	activates	cell_type	0.60
AUTOPHAGY	regulates	gene	0.60
MTORC1	regulates	gene	0.60
TSC22D3	regulates	gene	0.60
Autophagy	regulates	pathway	0.60
Mtor	regulates	pathway	0.60
Immune Response	regulates	pathway	0.60

Incoming (95)

Source	Relation	Type	Str
MICROGLIA	interacts_with	cell_type	0.65
MICROGLIA	activates	cell_type	0.65
IL-1	activates	gene	0.60
PPP5C	regulates	gene	0.60
JUN	regulates	gene	0.60
ADRA1D	regulates	gene	0.60
PDK4	regulates	gene	0.60
LITAF	regulates	gene	0.60
IL6R	regulates	gene	0.60
AXL	associated_with	gene	0.60
GRN	associated_with	gene	0.60
AXL	activates	gene	0.60
GRN	activates	gene	0.60
AXL	interacts_with	gene	0.60
GPR109A	activates	gene	0.60
C9ORF72	regulates	gene	0.60
GRN	regulates	gene	0.60
MAPT	regulates	gene	0.60
GRN	interacts_with	gene	0.60
TSC22D3	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
AND	regulates	gene	0.60
MTORC1	regulates	gene	0.60
GENES	regulates	gene	0.60
HDC	regulates	gene	0.60
AXL	regulates	gene	0.60
BAX	activates	gene	0.60
BCL2	activates	gene	0.60
ADAM8	activates	gene	0.60
AKT	activates	gene	0.60
ADCY9	regulates	gene	0.60
NPY1R	regulates	gene	0.60
DUSP1	regulates	gene	0.60
VPS37B	regulates	gene	0.60
NFKBIA	regulates	gene	0.60
SESN1	regulates	gene	0.60
MYH2	regulates	gene	0.60
CDKN1A	regulates	gene	0.60
NDRG2	regulates	gene	0.60
CALM2	regulates	gene	0.60
SOX2	regulates	gene	0.60
SOX9	regulates	gene	0.60
CD47	regulates	gene	0.60
C3	regulates	gene	0.60
ASTROCYTES	expressed_in	gene	0.60
ERK	expressed_in	gene	0.60
APOPTOSIS	activates	gene	0.60
LDL	activates	gene	0.60
ATP	activates	gene	0.60
MAPK	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TAM Receptor (MERTK/AXL) Cross-Regulation	0.540	neuroinflammation	What molecular mechanisms mediate SPP1-i

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity