gene

TBP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TBP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

57Connections

0Hypotheses

1Analyses

24Outgoing

33Incoming

0Experiments

1Debates

Summary

TBP - TATA-Box Binding Protein

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🧬 Gene Info

Gene Symbol	TBP
Full Name	TATA-Box Binding Protein
Chromosome	6q27
Protein Type	Transcription Factor
Function	is a general transcription factor essential for RNA polymerase II-mediated transcription initiation.
Amino Acids	339 aa
Exons	8
Pathways	Amyloid
UniProt ID	P20226
NCBI Gene ID	6908
Ensembl ID	ENSG00000112592
OMIM	600075
GeneCards	TBP
Human Protein Atlas	TBP
CBP (CREB-binding protein)	Depleting this essential histone acetyltransferase from the nucleus, reducing transcription of CREB-dependent survival genes
Associated Diseases	neurodegeneration
Interactions	AND, AXIN1, CCND1, EGR1, GENES, HNF4A
KG Connections	57 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TBP — AlphaFold P20226 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TBP["TBP"]
    Als["Als"]
    Ms["Ms"]
    Alzheimer["Alzheimer"]
    RELA["RELA"]
    CCND1["CCND1"]
    RHEB["RHEB"]
    SPI1["SPI1"]
    MIRNAS["MIRNAS"]
    HNF4A["HNF4A"]
    AXIN1["AXIN1"]
    HSP70["HSP70"]
    TXNIP["TXNIP"]
    SOCS3["SOCS3"]
    MICRORNAS["MICRORNAS"]
    AMYLOID["AMYLOID"]
    YWHAZ["YWHAZ"]
    MYC["MYC"]
    ALZHEIMER["ALZHEIMER"]
    MYH9["MYH9"]
    STAT3["STAT3"]
    TBP <-->|"interacts"| Als
    TBP -->|"expressed in"| Ms
    TBP -->|"regulates"| Alzheimer
    TBP -->|"activates"| RELA
    TBP -->|"activates"| CCND1
    TBP -->|"activates"| RHEB
    TBP -->|"activates"| SPI1
    TBP -->|"activates"| MIRNAS
    TBP -->|"activates"| HNF4A
    TBP -->|"activates"| AXIN1
    HSP70 -->|"expressed in"| TBP
    TXNIP -->|"activates"| TBP
    SOCS3 -->|"activates"| TBP
    MICRORNAS -->|"regulates"| TBP
    AMYLOID -->|"regulates"| TBP
    YWHAZ -->|"activates"| TBP
    MYC -->|"activates"| TBP
    ALZHEIMER -->|"regulates"| TBP
    MYH9 -->|"activates"| TBP
    STAT3 -->|"activates"| TBP
    style TBP fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (24)

Target	Relation	Type	Str
Ms	expressed_in	disease	0.65
Alzheimer	regulates	disease	0.65
Als	interacts_with	disease	0.65
HNF4A	activates	gene	0.60
AXIN1	activates	gene	0.60
MYC	activates	gene	0.60
YWHAZ	activates	gene	0.60
TXNIP	activates	gene	0.60
EGR1	activates	gene	0.60
STAT3	activates	gene	0.60
CCND1	activates	gene	0.60
MIRNAS	activates	gene	0.60
AND	activates	gene	0.60
GENES	activates	gene	0.60
ALZHEIMER	regulates	gene	0.60
AMYLOID	regulates	gene	0.60
MYH9	activates	gene	0.60
MIR-155	activates	gene	0.60
RELA	activates	gene	0.60
MICRORNAS	regulates	gene	0.60
RHEB	activates	gene	0.60
SPI1	activates	gene	0.60
Amyloid	regulates	pathway	0.60
Hippocampus	expressed_in	brain_region	0.55

Incoming (33)

Source	Relation	Type	Str
RAD50	interacts_with	gene	0.70
TXNIP	activates	gene	0.60
SOCS3	activates	gene	0.60
YWHAZ	activates	gene	0.60
MYC	activates	gene	0.60
STAT3	activates	gene	0.60
EGR1	activates	gene	0.60
CCNF	implicated_in	gene	0.60
HSP70	expressed_in	gene	0.60
DNAJC7	implicated_in	gene	0.60
GLT8D1	implicated_in	gene	0.60
KIF5A	implicated_in	gene	0.60
MFSD8	implicated_in	gene	0.60
NEK1	implicated_in	gene	0.60
TBK1	implicated_in	gene	0.60
MYO1C	activates	gene	0.60
CTSF	implicated_in	gene	0.60
AXIN1	activates	gene	0.60
RHEB	activates	gene	0.60
HNF4A	activates	gene	0.60
RELA	activates	gene	0.60
SPI1	activates	gene	0.60
MICRORNAS	regulates	gene	0.60
AMYLOID	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
MYH9	activates	gene	0.60
HUB GENES	regulates	gene	0.60
MIRNAS	activates	gene	0.60
MIR-155	activates	gene	0.60
AND	activates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
CCND1	activates	gene	0.60
GENES	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do dilncRNAs specifically drive molecular crowding and phase separation of D

neurodegeneration | 2026-04-08 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The abstract shows that dilncRNAs drive molecular crowding of DDR proteins into

closed · Rounds: 7 · Score: 0.90 · 2026-04-10

Related Research

Hypotheses and analyses mentioning TBP in their description or question text

No additional research found

TBP