gene

IL6R

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL6R: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

149Connections

0Hypotheses

0Analyses

50Outgoing

43Incoming

0Experiments

0Debates

Summary

IL6R is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, therapeutic target. Associated with ALS, Als, Cancer. Connected to 55 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	IL6R
Full Name	Interleukin 6 Receptor
Chromosome	1q21.3
Protein Type	Receptor
Function	IL-6R is a type I cytokine receptor that exists in both membrane-bound and soluble forms, mediating IL-6 signaling through multiple pathways:
Molecular Weight	50 kDa
Amino Acids	468 aa
Exons	10
Pathways	MAPK, PI3K
UniProt ID	P08887
NCBI Gene ID	3570
Ensembl ID	ENSG00000160712
OMIM	147610
GeneCards	IL6R
Human Protein Atlas	IL6R
Associated Diseases	bacterial_infections, Cancer, Carcinoma, Cardiovascular, Hepatitis, Pneumonia
Interactions	AND, CANCER, DNA, GENES, gp130, HNF4A
KG Connections	149 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: IL6R — AlphaFold P08887 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

il6r

gene · 1242 words

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Pathway Diagram

graph TD
    IL6R["IL6R"]
    gp130["gp130"]
    IL6R -->|"activates"| gp130
    Stroke{"Stroke"}
    IL6R -->|"inhibits"| Stroke
    Cardiovascular{"Cardiovascular"}
    IL6R -->|"therapeutic target"| Cardiovascular
    Als{"Als"}
    IL6R -->|"inhibits"| Als
    Hepatitis{"Hepatitis"}
    IL6R -->|"associated with"| Hepatitis
    Ms{"Ms"}
    IL6R -->|"regulates"| Ms
    Pneumonia{"Pneumonia"}
    IL6R -->|"associated with"| Pneumonia
    Cancer{"Cancer"}
    IL6R -->|"associated with"| Cancer
    Carcinoma{"Carcinoma"}
    IL6R -->|"associated with"| Carcinoma
    IL6R -->|"therapeutic target"| Ms
    ALS{"ALS"}
    IL6R -->|"inhibits"| ALS
    IL6R -->|"associated with"| Cardiovascular
    IL6["IL6"]
    IL6 -->|"interacts with"| IL6R
    proteases["proteases"]
    proteases -->|"catalyzes"| IL6R
    IL6 -->|"associated with"| IL6R
    IL6 -->|"activates"| IL6R
    GENES["GENES"]
    GENES -->|"activates"| IL6R
    HNF4A["HNF4A"]
    HNF4A -->|"activates"| IL6R
    PDGFRA["PDGFRA"]
    PDGFRA -->|"activates"| IL6R
    THBS2["THBS2"]
    THBS2 -->|"associated with"| IL6R
    MIRNAS["MIRNAS"]
    MIRNAS -->|"activates"| IL6R
    PI3K["PI3K"]
    PI3K -->|"associated with"| IL6R
    AKT["AKT"]
    AKT -->|"associated with"| IL6R
    CANCER["CANCER"]
    CANCER -->|"associated with"| IL6R
    style IL6R fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (106)

Target	Relation	Type	Str
tumor regression	therapeutic_target	phenotype	0.92
Neuromyelitis Optica Spectrum Disorder	therapeutic_target	disease	0.80
gp130	activates	protein	0.72
Carcinoma	associated_with	disease	0.65
Stroke	inhibits	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Als	inhibits	disease	0.65
Cancer	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Hepatitis	associated_with	disease	0.65
Pneumonia	associated_with	disease	0.65
ALS	inhibits	disease	0.65
Cardiovascular	associated_with	disease	0.65
Ms	regulates	disease	0.65
Tumor	inhibits	disease	0.65
Colorectal Cancer	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Aging	regulates	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Rheumatoid Arthritis	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
TSC22D3	regulates	gene	0.60
STING	activates	gene	0.60
MMP12	associated_with	gene	0.60
Rb	inhibits	protein	0.60
MITOCHONDRIAL DNA	activates	gene	0.60
CANCER	activates	gene	0.60
DNA	activates	gene	0.60
Metastasis	activates	pathway	0.60
Tumor Microenvironment	activates	pathway	0.60
AUTOPHAGY	regulates	gene	0.60
MTORC1	regulates	gene	0.60
STAT1	activates	gene	0.60
AND	inhibits	gene	0.60
CCND1	regulates	gene	0.60
CDKN1A	regulates	gene	0.60
SESN1	regulates	gene	0.60
IRF1	regulates	gene	0.60
NDRG2	regulates	gene	0.60
SOX9	regulates	gene	0.60
VPS37B	regulates	gene	0.60
NFKBIA	regulates	gene	0.60
CALM2	regulates	gene	0.60
NPY1R	regulates	gene	0.60
IL22	associated_with	gene	0.60
PVALB	associated_with	gene	0.60
PPP5C	regulates	gene	0.60
LITAF	regulates	gene	0.60

Incoming (43)

Source	Relation	Type	Str
IL6	interacts_with	gene	0.76
IL6	activates	gene	0.70
proteases	catalyzes	protein	0.68
PVALB	associated_with	gene	0.60
IL22	associated_with	gene	0.60
MMP12	associated_with	gene	0.60
THBS2	associated_with	gene	0.60
MIRNAS	activates	gene	0.60
STAT3	activates	gene	0.60
CANCER	associated_with	gene	0.60
IL6	inhibits	gene	0.60
CCND1	regulates	gene	0.60
HNF4A	activates	gene	0.60
PDGFRA	activates	gene	0.60
PI3K	associated_with	gene	0.60
AKT	associated_with	gene	0.60
STAT3	inhibits	gene	0.60
NPY1R	regulates	gene	0.60
MERTK	regulates	gene	0.60
CALM2	regulates	gene	0.60
VPS37B	regulates	gene	0.60
IL22	interacts_with	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
IL6	associated_with	gene	0.60
PPP5C	regulates	gene	0.60
JUN	regulates	gene	0.60
ADRA1D	regulates	gene	0.60
PDK4	regulates	gene	0.60
LITAF	regulates	gene	0.60
STROKE	inhibits	gene	0.60
IL-6	therapeutic_target	gene	0.60
RAGE	therapeutic_target	gene	0.60
IL1	inhibits	gene	0.60
IL1	associated_with	gene	0.60
IL1	activates	gene	0.60
GENES	activates	gene	0.60
CYTOKINES	therapeutic_target	gene	0.60
GENES	associated_with	gene	0.60
MTORC1	regulates	gene	0.60
adcy9	regulates	gene	0.50
adra1d	regulates	gene	0.50
Autophagy	regulates	process	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IL6R in their description or question text

No additional research found