gene

NF-ΚB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NF-ΚB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5428Connections

15Hypotheses

5Analyses

50Outgoing

50Incoming

0Experiments

13Debates

Summary

NF-ΚB is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, inhibits. Associated with ALS, Aging, Als. Connected to 2074 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NF
Function	Nf Κb P105 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
GeneCards	NF
Human Protein Atlas	NF
Associated Diseases	Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Anxiety, Atherosclerosis
Known Drugs/Compounds	Nicotiflorin, Sphingosine-1-Phosphate, Ursolic Acid, β-D-Manno-Heptose 1,7-bisphosphate
Interactions	ABCA1, ABCG1, ABIN1, ACE, ACHE, ACLY
KG Connections	2746 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    NF__B["NF-KappaB"] -->|"therapeutic target"| Cardiovascular["Cardiovascular"]
    NF__B["NF-KappaB"] -->|"therapeutic target"| Inflammation["Inflammation"]
    NF__B["NF-KappaB"] -->|"therapeutic target"| Als["Als"]
    NF__B["NF-KappaB"] -->|"therapeutic target"| Ms["Ms"]
    NF__B["NF-KappaB"] -->|"therapeutic target"| Tumor["Tumor"]
    NF__B["NF-KappaB"] -->|"therapeutic target"| Autoimmune["Autoimmune"]
    STAT3["STAT3"] -->|"associated"| NF__B["NF-KappaB"]
    MTOR["MTOR"] -->|"therapeutic target"| NF__B["NF-KappaB"]
    CD40["CD40"] -->|"therapeutic target"| NF__B["NF-KappaB"]
    CYTOKINES["CYTOKINES"] -->|"therapeutic target"| NF__B["NF-KappaB"]
    style NF__B fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (2176)

Target	Relation	Type	Str
NF-ΚB	encodes	protein	0.00
NEUROINFLAMMATION	inhibits	gene	1.00
TNF-Α	regulates	gene	1.00
Apoptosis	inhibits	pathway	1.00
Obesity	inhibits	disease	1.00
GENES	regulates	gene	1.00
Inflammasome	activates	pathway	1.00
AKT	regulates	gene	1.00
Innate Immunity	activates	pathway	1.00
Pi3K/Akt	regulates	pathway	1.00
NEURON	activates	gene	1.00
Parkinson	activates	disease	1.00
Toll-Like Receptor	activates	pathway	1.00
Neuroinflammation	inhibits	disease	1.00
MTOR	inhibits	gene	1.00
NEURODEGENERATIVE DISEASES	activates	gene	1.00
Als	regulates	disease	1.00
GENES	activates	gene	1.00
Autophagy	inhibits	pathway	1.00
Atherosclerosis	inhibits	disease	1.00
Inflammation	associated_with	disease	1.00
Inflammation	regulates	disease	1.00
Alzheimer	activates	disease	1.00
Glycolysis	activates	pathway	1.00
Mapk	inhibits	pathway	1.00
Aging	activates	disease	1.00
Oxidative Stress	inhibits	pathway	1.00
Mapk	activates	pathway	1.00
Tumor	associated_with	disease	1.00
P53	activates	gene	1.00
Autoimmune	activates	disease	1.00
Als	associated_with	disease	1.00
UBIQUITIN	activates	gene	1.00
Cancer	associated_with	disease	1.00
Tumor	regulates	disease	1.00
ASTROCYTE	activates	gene	1.00
Inflammation	causes	disease	1.00
MICROGLIA	activates	gene	1.00
Neurodegeneration	activates	disease	1.00
NRF2	regulates	gene	1.00
Tumor	inhibits	disease	1.00
Mtor	inhibits	pathway	1.00
Apoptosis	regulates	pathway	1.00
Immune Response	activates	pathway	1.00
Oxidative Stress	activates	pathway	1.00
NEUROINFLAMMATION	activates	gene	1.00
Als	inhibits	disease	1.00
Alzheimer	therapeutic_target	disease	1.00
Nf-Κb	inhibits	pathway	1.00
Cancer	inhibits	disease	1.00

Incoming (3252)

Source	Relation	Type	Str
NF-ΚB	encodes	gene	0.00
AKT	activates	gene	1.00
NEURODEGENERATIVE DISEASES	activates	gene	1.00
Inflammation	inhibits	disease	1.00
PI3K	activates	gene	1.00
NLRP3	activates	gene	1.00
OXIDATIVE STRESS	inhibits	gene	1.00
TNF	inhibits	gene	1.00
Autoimmune	activates	disease	1.00
Neuroinflammation	inhibits	disease	1.00
SIRT1	activates	gene	1.00
NRF2	activates	gene	1.00
TNF	inhibits	gene	1.00
APOPTOSIS	activates	gene	1.00
TLR4	activates	gene	1.00
NEURODEGENERATION	activates	gene	1.00
PARKINSON	activates	gene	1.00
SIRT1	activates	gene	1.00
APOPTOSIS	regulates	gene	1.00
OXIDATIVE STRESS	inhibits	gene	1.00
APOPTOSIS	therapeutic_target	gene	1.00
OXIDATIVE STRESS	therapeutic_target	gene	1.00
MTOR	activates	gene	1.00
PARKINSON	activates	gene	1.00
MTOR	regulates	gene	1.00
PI3K	inhibits	gene	1.00
Aging	activates	disease	1.00
PARKINSON'S DISEASE	activates	gene	1.00
AUTOPHAGY	regulates	gene	1.00
NEUROINFLAMMATION	inhibits	gene	1.00
APOPTOSIS	regulates	gene	1.00
APOPTOSIS	inhibits	gene	1.00
CANCER	therapeutic_target	gene	1.00
NEURODEGENERATION	activates	gene	1.00
JNK	activates	gene	1.00
ASTROCYTES	activates	gene	1.00
AUTOPHAGY	activates	gene	1.00
ERK	activates	gene	1.00
ERK	activates	gene	1.00
CANCER	regulates	gene	1.00
UBIQUITIN	activates	gene	1.00
OXIDATIVE STRESS	activates	gene	1.00
OXIDATIVE STRESS	therapeutic_target	gene	1.00
APOPTOSIS	therapeutic_target	gene	1.00
MICROGLIA	activates	gene	1.00
MITOCHONDRIAL DYSFUNCTION	activates	gene	1.00
TLR4	activates	gene	1.00
PARKINSON'S DISEASE	activates	gene	1.00
TLR4	inhibits	gene	1.00
Alzheimer	activates	disease	1.00

Targeting Hypotheses (15)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SCFA Deficiency Drives Microglial Hyperactivation via GPR43/	0.728	neurodegeneration	How does gut microbiome dysbiosis contri
TLR4/MyD88/NF-κB Axis Blockade to Interrupt LPS-Mediated Gut	0.703	neurodegeneration	How do gut microbiome-derived metabolite
TNF-α/NF-κB Axis Upregulates P2RY12 in VSMCs	0.650	neurodegeneration	What determines P2RY12 receptor expressi
S100B as Active Pathogenic BBB-Disrupting Signal via RAGE/NF	0.647	-	Blood-brain barrier permeability changes
LPS-TLR4-NF-κB Signaling Cascade as Therapeutic Target	0.619	neurodegeneration	Gut-Brain Axis in Parkinson's Disease: M

TNF-α–C1r/C1s Bridge Between NF-κB and Classical Complement	0.600	neuroinflammation	How does sevoflurane-induced NF-κB activ
Astrocyte-Derived EV miR-146a-5p Mimics as Erasers of Traine	0.588	neuroinflammation	What specific astrocyte-derived factors
αvβ3 Integrin-FAK-SYK-CARD9/NF-κB Pathway	0.580	neuroinflammation	What molecular mechanisms mediate SPP1-i
Microglial Priming via NF-κB-Dependent DAM Phenotype and Com	0.580	neuroinflammation	How does sevoflurane-induced NF-κB activ
Direct NF-κB Transcriptional Regulation of C1q Genes in Micr	0.570	neuroinflammation	How does sevoflurane-induced NF-κB activ
Dual NF-κB/MMP Inhibition Strategy	0.554	-	Blood-brain barrier tight junction disru
CD36 Acts as Primary Aβ Oligomer Sensor on Perivascular Macr	0.535	neurodegeneration	How do perivascular cells specifically r
GATA4 Stabilization and NF-κB Co-activation Identifies Senes	0.520	neurodegeneration	How can senescent microglia be molecular
YAP/TAZ Mechanosensing Cooperates with NF-κB to Amplify SPP1	0.492	neurodegeneration	How do perivascular cells specifically r
Convergent NF-κB enhancers across diverse priming stimuli sh	0.380	Alzheimer's disease	Do different priming stimuli require dis

Mentioning Analyses (5)

Scientific analyses that reference this entity

How does gut microbiome dysbiosis contribute to neuroinflammation and neurodegen

neurodegeneration | 2026-04-26 | 7 hypotheses Top: 0.728

What determines the GPX4/ACSL4 balance that switches microglia from protective t

immunology | 2026-04-15 | 0 hypotheses

What molecular mechanisms enable Gal3 to enhance tau fibrillation upon binding t

neurodegeneration | 2026-04-15 | 0 hypotheses

How do perivascular cells specifically recognize and respond to amyloid-β to upr

neurodegeneration | 2026-04-06 | 7 hypotheses Top: 0.618

Senescent cell clearance as neurodegeneration therapy

neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.769

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (7)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Chrysophanol Attenuates Cognitive Impairment, Neuroinflammation, and Oxidative S [PMID:40728692]	Khan JZ, Zainab SR, Alattar A	Neurochem Res	2025
Qingda granule alleviates cerebral ischemia/reperfusion injury by inhibiting TLR [PMID:38184025]	Unknown	Journal of ethnopharmacology	2024
Ketogenic diet attenuates neuroinflammation and induces conversion of M1 microgl [PMID:37466915]	Sun W, Wang Q, Zhang R, Zhang N	Food & function	2023
NLRP3 inflammasome inhibition and M1-to-M2 microglial polarization shifting via [PMID:37137264]	Ibrahim Weam W; Skalicka-Woźniak K	International immunopharmacolo	2023
Microglia clear neuron-released α-synuclein via selective autophagy and prevent [PMID:32170061]	Choi I, Zhang Y, Seegobin SP	Nat Commun	2020
Lipocalin 2 induces neuroinflammation and blood-brain barrier dysfunction throug [PMID:32622362]	Mondal A, Bose D, Saha P	J Neuroinflammation	2020
RETRACTED: Hesperetin, a Citrus Flavonoid, Attenuates LPS-Induced Neuroinflammat [PMID:30884890]	["Muhammad T", "Ikram M", "Ullah R", "Re	Nutrients	2019

Debates (13)

Multi-agent debates referencing this entity

Extended debate: Metabolic Reprogramming to Reverse Senescence

closed · Rounds: 6 · Score: 0.95 · 2026-04-27

Debate: SCFA Deficiency Drives Microglial Hyperactivation via GPR43/NF-κB Dysreg

closed · Rounds: 4 · Score: 0.13 · 2026-04-27

Hypothesis debate: Metabolic Reprogramming to Reverse Senescence

closed · Rounds: 4 · Score: 0.44 · 2026-04-27

How does gut microbiome dysbiosis contribute to neuroinflammation and neurodegen

closed · Rounds: 4 · Score: 0.76 · 2026-04-26

Hypothesis debate: SASP Modulation Rather Than Cell Elimination

closed · Rounds: 4 · Score: 0.50 · 2026-04-26

Hypothesis debate: Metabolic Reprogramming to Reverse Senescence

closed · Rounds: 4 · Score: 0.50 · 2026-04-26

Hypothesis debate: Metabolic Reprogramming to Reverse Senescence

closed · Rounds: 4 · Score: 0.50 · 2026-04-26

Should metabolic reprogramming via SIRT1/NAD+/PGC-1alpha axis be prioritized to

closed · Rounds: 4 · Score: 0.81 · 2026-04-23

The abstract indicates SPP1 upregulation occurs in perivascular macrophages and

closed · Rounds: 4 · Score: 0.67 · 2026-04-22

Investigate the therapeutic potential of clearing senescent cells (senolytics) t

closed · Rounds: 4 · Score: 0.75 · 2026-04-16

Related Research

Hypotheses and analyses mentioning NF-ΚB in their description or question text

NF-ΚB

Understanding Entity Pages

Summary

Pathway Diagram

Outgoing (2176)

Incoming (3252)

Targeting Hypotheses (15)

Mentioning Analyses (5)

How does gut microbiome dysbiosis contribute to neuroinflammation and neurodegen

What determines the GPX4/ACSL4 balance that switches microglia from protective t

What molecular mechanisms enable Gal3 to enhance tau fibrillation upon binding t

How do perivascular cells specifically recognize and respond to amyloid-β to upr

Senescent cell clearance as neurodegeneration therapy

Experiments (0)

Related Papers (7)

Debates (13)

Extended debate: Metabolic Reprogramming to Reverse Senescence

Debate: SCFA Deficiency Drives Microglial Hyperactivation via GPR43/NF-κB Dysreg

Hypothesis debate: Metabolic Reprogramming to Reverse Senescence

How does gut microbiome dysbiosis contribute to neuroinflammation and neurodegen

Hypothesis debate: SASP Modulation Rather Than Cell Elimination

Hypothesis debate: Metabolic Reprogramming to Reverse Senescence

Hypothesis debate: Metabolic Reprogramming to Reverse Senescence

Should metabolic reprogramming via SIRT1/NAD+/PGC-1alpha axis be prioritized to

The abstract indicates SPP1 upregulation occurs in perivascular macrophages and

Investigate the therapeutic potential of clearing senescent cells (senolytics) t

Related Research

TNF-α–C1r/C1s Bridge Between NF-κB and Classical Complement Cascade

Astrocyte-Derived EV miR-146a-5p Mimics as Erasers of Trained Microglial NF-κB M

αvβ3 Integrin-FAK-SYK-CARD9/NF-κB Pathway

Microglial Priming via NF-κB-Dependent DAM Phenotype and Complement Biosynthesis

Direct NF-κB Transcriptional Regulation of C1q Genes in Microglia

Dual NF-κB/MMP Inhibition Strategy

CD36 Acts as Primary Aβ Oligomer Sensor on Perivascular Macrophages, Triggering

GATA4 Stabilization and NF-κB Co-activation Identifies Senescent Microglia

YAP/TAZ Mechanosensing Cooperates with NF-κB to Amplify SPP1 Transcription in Pe

Convergent NF-κB enhancers across diverse priming stimuli share therapeutic vuln