gene

HNF4A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HNF4A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

100Connections

0Hypotheses

0Analyses

50Outgoing

33Incoming

0Experiments

0Debates

Summary

HNF4A encodes a nuclear receptor transcription factor critical for metabolic regulation, with emerging roles in Alzheimer's and Parkinson's disease pathogenesis.

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🧬 Gene Info

Gene Symbol	HNF4A
Full Name	Hepatocyte Nuclear Factor 4 Alpha
Chromosome	20q13.12
Protein Type	Receptor
Function	is a nuclear receptor transcription factor that plays essential roles in metabolic regulation, organ development, and cellular homeostasis.
Primary Expression	neurons across multiple regions
Amino Acids	465 aa
Exons	13
Pathways	Amyloid
UniProt ID	[P41235](https://www.uniprot.org/uniprot/P41235)
Ensembl ID	ENSG00000101076
GeneCards	HNF4A
Human Protein Atlas	HNF4A
Promoter P1	Drives expression in liver, pancreas, and kidney
Promoter P2	Active in brain, muscle, and other tissues
Associated Diseases	Hepatitis
Interactions	AKT, AKT1, AND, AXIN1, CANCER, CCND1
KG Connections	100 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HNF4A - Hepatocyte Nuclear Factor 4 Alpha

gene · 1662 words

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Pathway Diagram

graph TD
    HNF4A["HNF4A"]
    Hepatitis{"Hepatitis"}
    HNF4A -->|"associated with"| Hepatitis
    Ms{"Ms"}
    HNF4A -->|"regulates"| Ms
    Diabetes{"Diabetes"}
    HNF4A -->|"regulates"| Diabetes
    Als{"Als"}
    HNF4A -->|"regulates"| Als
    IL6R["IL6R"]
    HNF4A -->|"activates"| IL6R
    STAT3["STAT3"]
    HNF4A -->|"regulates"| STAT3
    Cholesterol(["Cholesterol"])
    HNF4A -->|"associated with"| Cholesterol
    GAD2["GAD2"]
    HNF4A -->|"expressed in"| GAD2
    USH1C["USH1C"]
    HNF4A -->|"regulates"| USH1C
    neurodegeneration["neurodegeneration"]
    HNF4A -->|"implicated in"| neurodegeneration
    APOC2["APOC2"]
    APOC2 -->|"regulates"| HNF4A
    IL6["IL6"]
    IL6 -->|"activates"| HNF4A
    GENES["GENES"]
    GENES -->|"regulates"| HNF4A
    ABCD3["ABCD3"]
    ABCD3 -->|"regulates"| HNF4A
    style HNF4A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (67)

Target	Relation	Type	Str
Als	activates	disease	0.65
Carcinoma	activates	disease	0.65
Cancer	activates	disease	0.65
Carcinoma	regulates	disease	0.65
Cancer	regulates	disease	0.65
Tumor	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Carcinoma	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Ms	regulates	disease	0.65
Hepatitis	associated_with	disease	0.65
Diabetes	regulates	disease	0.65
Als	regulates	disease	0.65
Tumor	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Renal Cell Carcinoma	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
MYH9	activates	gene	0.60
MIR-155	activates	gene	0.60
IL6R	activates	gene	0.60
STAT3	regulates	gene	0.60
MIRNAS	encodes	gene	0.60
RHEB	activates	gene	0.60
CANCER	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
STAT3	activates	gene	0.60
MYH9	encodes	gene	0.60
CCND1	encodes	gene	0.60
MICRORNAS	regulates	gene	0.60
AMYLOID	regulates	gene	0.60
AND	activates	gene	0.60
GENES	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
Akt	inhibits	pathway	0.60
Cholesterol	inhibits	pathway	0.60
CANCER	regulates	gene	0.60
CCND1	activates	gene	0.60
GENES	activates	gene	0.60
Amyloid	regulates	pathway	0.60
ALZHEIMER	regulates	gene	0.60
AKT	inhibits	gene	0.60
MYC	activates	gene	0.60
YWHAZ	activates	gene	0.60
TXNIP	activates	gene	0.60
SOCS3	activates	gene	0.60
RELA	activates	gene	0.60
SPI1	activates	gene	0.60
TBP	activates	gene	0.60
CANCER	activates	gene	0.60

Incoming (33)

Source	Relation	Type	Str
MICRORNAS	regulates	gene	0.60
AMYLOID	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
MYH9	activates	gene	0.60
CCND1	activates	gene	0.60
MIRNAS	activates	gene	0.60
HUB GENES	regulates	gene	0.60
MIR-155	activates	gene	0.60
AND	activates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
IL6	activates	gene	0.60
ABCD3	regulates	gene	0.60
AKT1	inhibits	gene	0.60
YAP1	regulates	gene	0.60
TXNIP	activates	gene	0.60
SOCS3	activates	gene	0.60
YWHAZ	activates	gene	0.60
MYC	activates	gene	0.60
STAT3	activates	gene	0.60
EGR1	activates	gene	0.60
TBP	activates	gene	0.60
RELA	activates	gene	0.60
RHEB	activates	gene	0.60
SPI1	activates	gene	0.60
AXIN1	activates	gene	0.60
AND	associated_with	gene	0.60
C-MYC	associated_with	gene	0.60
AND	inhibits	gene	0.60
AND	regulates	gene	0.60
MYC	associated_with	gene	0.60
AXIN1	encodes	gene	0.60
MITOCHONDRIAL DYSFUNCTION	expressed_in	gene	0.60
GENES	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HNF4A in their description or question text

No additional research found