gene

VPS37B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VPS37B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

66Connections

0Hypotheses

0Analyses

37Outgoing

29Incoming

0Experiments

0Debates

Summary

VPS37B encodes ESCRT-I subunit involved in endosomal trafficking, linked to Parkinson's disease and lysosomal disorders.

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🧬 Gene Info

Gene Symbol	VPS37B
Full Name	Vacuolar Protein Sorting 37 Homolog B
Chromosome	14q23.3
Function	is a core component of the ESCRT-I (Endosomal Sorting Complex Required for Transport-I) complex, critical for endosomal trafficking and multivesicular body (MVB) formation[@structure2009].
Molecular Weight	21 kDa
Amino Acids	184 aa
Pathways	Autophagy, Cell Cycle, Immune Response, Mtor
UniProt ID	Q9H8Y8
NCBI Gene ID	203197
Ensembl ID	ENSG00000139517
GeneCards	VPS37B
Human Protein Atlas	VPS37B
Associated Diseases	neurodegeneration
KG Connections	66 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: VPS37B — AlphaFold Q9H8Y8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

VPS37B Gene

gene · 960 words

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Pathway Diagram

graph TD
    VPS37B["VPS37B"]
    CHMP4B["CHMP4B"]
    MTORC1["MTORC1"]
    NFKBIA["NFKBIA"]
    CALM2["CALM2"]
    TSC22D3["TSC22D3"]
    NPY1R["NPY1R"]
    Autophagy["Autophagy"]
    Mtor["Mtor"]
    Immune_Response["Immune Response"]
    DNAJB6["DNAJB6"]
    PPP5C["PPP5C"]
    JUN["JUN"]
    ADRA1D["ADRA1D"]
    PDK4["PDK4"]
    LITAF["LITAF"]
    IL6R["IL6R"]
    CCND1["CCND1"]
    MERTK["MERTK"]
    DUSP1["DUSP1"]
    ADCY9["ADCY9"]
    VPS37B -.-|"associated"| CHMP4B
    VPS37B -->|"regulates"| MTORC1
    VPS37B -->|"regulates"| NFKBIA
    VPS37B -->|"regulates"| CALM2
    VPS37B -->|"regulates"| TSC22D3
    VPS37B -->|"regulates"| NPY1R
    VPS37B -->|"regulates"| Autophagy
    VPS37B -->|"regulates"| Mtor
    VPS37B -->|"regulates"| Immune_Response
    DNAJB6 -.-|"associated"| VPS37B
    PPP5C -->|"regulates"| VPS37B
    JUN -->|"regulates"| VPS37B
    ADRA1D -->|"regulates"| VPS37B
    PDK4 -->|"regulates"| VPS37B
    LITAF -->|"regulates"| VPS37B
    IL6R -->|"regulates"| VPS37B
    CCND1 -->|"regulates"| VPS37B
    MERTK -->|"regulates"| VPS37B
    DUSP1 -->|"regulates"| VPS37B
    ADCY9 -->|"regulates"| VPS37B
    style VPS37B fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (37)

Target	Relation	Type	Str
LITAF	regulates	gene	0.60
SESN1	regulates	gene	0.60
PDK4	regulates	gene	0.60
MYH2	regulates	gene	0.60
CDKN1A	regulates	gene	0.60
JUN	regulates	gene	0.60
NDRG2	regulates	gene	0.60
SOX2	regulates	gene	0.60
SOX9	regulates	gene	0.60
MERTK	regulates	gene	0.60
IRF1	regulates	gene	0.60
MTORC1	regulates	gene	0.60
TSC22D3	regulates	gene	0.60
Cell Cycle	regulates	pathway	0.60
App	associated_with	protein	0.60
NFKBIA	regulates	gene	0.60
CALM2	regulates	gene	0.60
NPY1R	regulates	gene	0.60
CHMP4B	associated_with	gene	0.60
IL6R	regulates	gene	0.60
DUSP1	regulates	gene	0.60
ADRA1D	regulates	gene	0.60
PPP5C	regulates	gene	0.60
ADCY9	regulates	gene	0.60
Nfkb	regulates	protein	0.60
Autophagy	regulates	pathway	0.60
Mtor	regulates	pathway	0.60
Immune Response	regulates	pathway	0.60
AUTOPHAGY	regulates	gene	0.60
AND	regulates	gene	0.60
CCND1	regulates	gene	0.60
GENES	regulates	gene	0.60
HDC	regulates	gene	0.60
Actin	regulates	protein	0.60
DNAJB6	associated_with	gene	0.50
Proteins	associated_with	protein	0.50
IMMUNE RESPONSE	regulates	pathway	0.50

Incoming (29)

Source	Relation	Type	Str
AND	associated_with	gene	0.60
DNAJB6	associated_with	gene	0.60
HDC	regulates	gene	0.60
TSC22D3	regulates	gene	0.60
NPY1R	regulates	gene	0.60
SOX9	regulates	gene	0.60
MYH2	regulates	gene	0.60
CHMP4B	associated_with	gene	0.60
PPP5C	regulates	gene	0.60
JUN	regulates	gene	0.60
ADRA1D	regulates	gene	0.60
PDK4	regulates	gene	0.60
LITAF	regulates	gene	0.60
IL6R	regulates	gene	0.60
MERTK	regulates	gene	0.60
DUSP1	regulates	gene	0.60
ADCY9	regulates	gene	0.60
SOX2	regulates	gene	0.60
CDKN1A	regulates	gene	0.60
SESN1	regulates	gene	0.60
IRF1	regulates	gene	0.60
NDRG2	regulates	gene	0.60
CCND1	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
MTORC1	regulates	gene	0.60
adra1d	regulates	gene	0.50
Autophagy	regulates	process	0.50
adcy9	regulates	gene	0.50
CALM2	regulates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning VPS37B in their description or question text

No additional research found