gene

NFKBIA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NFKBIA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

322Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

NFKBIA is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, biomarker for. Associated with Als, Alzheimer, Cancer. Connected to 133 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NFKBIA
Full Name	NFKB Inhibitor Alpha
Chromosome	14q13
Molecular Weight	37 kDa
Amino Acids	317 aa
Exons	7 exons encoding the IκBα protein
Pathways	NFKB, NF-κB
UniProt ID	P19838
NCBI Gene ID	4792
Ensembl ID	ENSG0000096927
OMIM	164008
GeneCards	NFKBIA
Human Protein Atlas	NFKBIA
Promoter	Contains NF-κB binding sites, making expression auto-regulatory
3' UTR	Contains AU-rich elements (AREs) regulating mRNA stability
Associated Diseases	Hepatitis, Inflammation, Ms
Interactions	AND, APOPTOSIS, ASTROCYTES, AUTOPHAGY, BMAL1, BNIP3
KG Connections	321 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NFKBIA — AlphaFold P19838 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NFKBIA Gene (NFKB Inhibitor Alpha)

gene · 1472 words

→

NFKBIA Protein

protein · 787 words

→

Pathway Diagram

graph TD
    NFKBIA["NFKBIA"]
    NFKBIA -.biomarker for.-> Als["Als"]
    NFKBIA -->|"regulates"| Parkinson["Parkinson"]
    NFKBIA -->|"regulates"| Ms["Ms"]
    NFKBIA -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    NFKBIA -->|"regulates"| Inflammation["Inflammation"]
    NFKBIA -->|"activates"| Cancer["Cancer"]
    NFKBIA -->|"activates"| Tumor["Tumor"]
    NFKBIA -.biomarker for.-> Apoptosis["Apoptosis"]
    TRAF6["TRAF6"] -.biomarker for.-> NFKBIA
    P38["P38"] -.biomarker for.-> NFKBIA
    CD4["CD4"] -.biomarker for.-> NFKBIA
    EGR2["EGR2"] -.biomarker for.-> NFKBIA
    TNF["TNF"] -.biomarker for.-> NFKBIA
    SPI1["SPI1"] -.biomarker for.-> NFKBIA
    GENES["GENES"] -.biomarker for.-> NFKBIA
    STXBP2["STXBP2"] -.biomarker for.-> NFKBIA
    FLNA["FLNA"] -.biomarker for.-> NFKBIA
    CTSD["CTSD"] -.biomarker for.-> NFKBIA

Outgoing (199)

Target	Relation	Type	Str
NFKB1	inhibits	protein	0.95
NFKB	inhibits	protein	0.90
RELA	regulates	protein	0.90
NF-kB signaling	participates_in	pathway	0.80
Neuroinflammation	regulates	disease	0.75
Inflammation	regulates	disease	0.75
NEUROINFLAMMATION	regulates	gene	0.70
Ms	inhibits	disease	0.65
Parkinson	regulates	disease	0.65
Als	biomarker_for	disease	0.65
Hepatitis	associated_with	disease	0.65
Ms	regulates	disease	0.65
Inflammation	inhibits	disease	0.65
Neurodegeneration	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Addiction	biomarker_for	disease	0.65
Ms	expressed_in	disease	0.65
Traumatic Brain Injury	regulates	disease	0.65
ALS	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Ms	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Ms	activates	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Aging	expressed_in	disease	0.65
Cancer	activates	disease	0.65
Senescence	inhibits	disease	0.65
Tumor	activates	disease	0.65
MITOCHONDRIA	regulates	gene	0.60
NFKB	activates	gene	0.60
ALZHEIMER	biomarker_for	gene	0.60
HIPPO	biomarker_for	gene	0.60
AUTOPHAGY	regulates	gene	0.60
MTORC1	regulates	gene	0.60
CCND1	regulates	gene	0.60
GENES	activates	gene	0.60
HDC	regulates	gene	0.60
Cell Cycle	regulates	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
AND	inhibits	gene	0.60
AND	regulates	gene	0.60
JUNB	biomarker_for	gene	0.60
TNF	biomarker_for	gene	0.60
STXBP2	biomarker_for	gene	0.60
TRAF6	biomarker_for	gene	0.60
EGR2	biomarker_for	gene	0.60
SPI1	biomarker_for	gene	0.60
P38	biomarker_for	gene	0.60
CTSD	biomarker_for	gene	0.60
TRIM25	activates	gene	0.60

Incoming (123)

Source	Relation	Type	Str
PHF2	regulates	enzyme	0.95
TRIM25	degrades	gene	0.90
Berberine	suppresses	compound	0.90
Scutellarein	downregulates	compound	0.85
TRIM25	mediates	gene	0.85
NFKB	triggers_ubiquitination_dependent_degradation_by_TRIM25	protein	0.80
PROTEASOME INHIBITION	inhibits	gene	0.60
ALZHEIMER	biomarker_for	gene	0.60
TNFRSF1A	regulates	gene	0.60
STAT3	regulates	gene	0.60
BMAL1	inhibits	gene	0.60
CALM2	regulates	gene	0.60
BNIP3	inhibits	gene	0.60
YWHAZ	expressed_in	gene	0.60
HSP90AB1	expressed_in	gene	0.60
CAV1	expressed_in	gene	0.60
VDAC1	expressed_in	gene	0.60
PI3K	expressed_in	gene	0.60
SOD1	expressed_in	gene	0.60
RELA	expressed_in	gene	0.60
ITGAM	expressed_in	gene	0.60
PPARG	expressed_in	gene	0.60
TP53	expressed_in	gene	0.60
AKT	expressed_in	gene	0.60
HSPA4	expressed_in	gene	0.60
CYCS	expressed_in	gene	0.60
NFKB	inhibits	gene	0.60
ENO1	expressed_in	gene	0.60
MICROGLIA	inhibits	gene	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
MICROGLIA	regulates	gene	0.60
ALPHA-SYNUCLEIN	regulates	gene	0.60
MITOPHAGY	regulates	gene	0.60
ASTROCYTES	regulates	gene	0.60
CCND1	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
MTORC1	regulates	gene	0.60
TSC22D3	regulates	gene	0.60
AND	activates	gene	0.60
AND	inhibits	gene	0.60
GUCY1B1	regulates	gene	0.60
TAU	regulates	gene	0.60
NCOA4	activates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.60
BCL2L1	associated_with	gene	0.60
CASP1	associated_with	gene	0.60
TP53	associated_with	gene	0.60
MYC	associated_with	gene	0.60
JUN	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NFKBIA in their description or question text

No additional research found