gene

RELA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RELA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

752Connections

9Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

RELA is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, therapeutic target. Associated with Aging, Als, Alzheimer. Connected to 379 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NF
Full Name	κB p65 Protein
Aliases	RELA
Function	Nf Κb P105 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
GeneCards	NF
Human Protein Atlas	NF
Associated Diseases	Aging, Als, Cancer, Glioblastoma, Hepatitis, Inflammation
Known Drugs/Compounds	RESVERATROL
Interactions	AKT, AKT1, ALZHEIMER, ALZHEIMER DISEASE, AMYLOID, AND
KG Connections	752 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    RELA["RELA"]
    RELA -->|"activates"| Cancer["Cancer"]
    RELA -->|"activates"| Inflammation["Inflammation"]
    RELA -->|"activates"| Aging["Aging"]
    RELA -->|"activates"| Ms["Ms"]
    RELA -->|"activates"| Carcinoma["Carcinoma"]
    RELA -->|"activates"| Tumor["Tumor"]
    RELA -->|"interacts"| Als["Als"]
    NRF2["NRF2"] -->|"inhibits"| RELA
    P38["P38"] -->|"activates"| RELA
    MAP1LC3["MAP1LC3"] -->|"activates"| RELA
    IL1B["IL1B"] -->|"activates"| RELA
    PRDX1["PRDX1"] -->|"activates"| RELA
    TRAF6["TRAF6"] -->|"activates"| RELA
    CHUK["CHUK"] -->|"activates"| RELA
    PRDX6["PRDX6"] -->|"activates"| RELA

Outgoing (471)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:RELA	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Senescence-Associated Secretory Phenotype	promotes	phenotype	0.95
Inflammation	activates	disease	0.95
MIR125B	upregulates	gene	0.90
YY1	activates	gene	0.90
Nuclear Translocation	involved_in	process	0.90
CANCER	activates	gene	0.90
Cancer	activates	disease	0.85
Als	interacts_with	disease	0.85
Als	expressed_in	disease	0.85
Als	activates	disease	0.85
Osteoclast Differentiation	regulates	process	0.85
Tumor	activates	disease	0.85
MIR125B	regulates	biomarker	0.85
MIR9	regulates	biomarker	0.80
Nf-Κb	interacts_with	pathway	0.80
Cancer	therapeutic_target	disease	0.75
Carcinoma	activates	disease	0.75
Inflammation	regulates	disease	0.75
Als	therapeutic_target	disease	0.75
Mapk	therapeutic_target	pathway	0.70
ISCHEMIA	causes	disease	0.70
Nf-Κb	expressed_in	pathway	0.70
CANCER	therapeutic_target	gene	0.70
ISCHEMIA	modifies	disease	0.70
NEURONS	protects_against	cell_type	0.70
Apoptosis	activates	pathway	0.70
Nf-Κb	regulates	pathway	0.70
Nf-Κb	activates	pathway	0.70
Nf-Κb	therapeutic_target	pathway	0.70
Ms	inhibits	disease	0.65
Inflammation	associated_with	disease	0.65
Hypertension	therapeutic_target	disease	0.65
ISCHEMIA	phosphorylates	disease	0.65
Ischemia	therapeutic_target	disease	0.65
Ms	expressed_in	disease	0.65
Obesity	therapeutic_target	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Stroke	therapeutic_target	disease	0.65
Aging	associated_with	disease	0.65
NEURON	interacts_with	cell_type	0.65
Als	regulates	disease	0.65
Lymphoma	regulates	disease	0.65
Dementia	expressed_in	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Atherosclerosis	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Alzheimer	expressed_in	disease	0.65
Ms	therapeutic_target	disease	0.65

Incoming (281)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:RELA	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
IKBKG	phosphorylates	gene	0.90
NFKBIA	regulates	protein	0.90
Lapiferin	downregulates	compound	0.90
Riboflavin	suppresses	drug	0.87
Scutellarein	downregulates	compound	0.85
IKBA	inhibits	protein	0.85
TNF	therapeutic_target	gene	0.70
NF-ΚB	therapeutic_target	gene	0.70
AKT1	therapeutic_target	gene	0.70
STAT3	interacts_with	gene	0.70
NRF2	inhibits	protein	0.70
RESVERATROL	treats	drug	0.70
INFLAMMATION	regulates	gene	0.70
NF-ΚB	interacts_with	gene	0.70
INFLAMMATION	activates	gene	0.70
CYTOKINES	activates	gene	0.70
TP53	therapeutic_target	gene	0.70
ALS	treats	disease	0.70
MYC	regulates	gene	0.65
MITOPHAGY	inhibits	phenotype	0.65
ROS	inhibits	phenotype	0.65
NEURODEGENERATION	regulates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
MIRNAS	therapeutic_target	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
ERBB2	therapeutic_target	gene	0.60
HIF	therapeutic_target	gene	0.60
AND	activates	gene	0.60
GENES	activates	gene	0.60
INFLAMMATION	associated_with	gene	0.60
PYROPTOSIS	activates	gene	0.60
HUB GENES	associated_with	gene	0.60
MIRNAS	activates	gene	0.60
MIR-155	activates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
CCND1	activates	gene	0.60
GENES	associated_with	gene	0.60
STROKE	therapeutic_target	gene	0.60
IL-17	therapeutic_target	gene	0.60
C-JUN	regulates	gene	0.60
MALAT1	interacts_with	gene	0.60
P2RX3	regulates	gene	0.60
NF-ΚB	regulates	gene	0.60
APOPTOSIS	activates	gene	0.60

Targeting Hypotheses (9)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
CYP46A1 Gene Therapy for Age-Related TREM2-Mediated Microgli	0.921	neurodegeneration	Lipid raft composition changes in synapt
FABP5/7 Inhibition (H2): Lipid Relay Interruption	0.670	neurodegeneration	Does restoring neuronal AMPK activity re
H4: Age-Related Hsp70 Chaperone Decline Blocks Granule Rever	0.577	neurodegeneration	How do pathological stress granules tran
H4: Polycomb Repression Relaxes at Neurodevelopment Genes	0.530	neurodegeneration	Investigate mechanisms of epigenetic rep
Microglial Reactivation Status Modifies Amyloid Clearance an	0.524	neurodegeneration	-

HDAC1/2 Complex Restoration Corrects Age-Related Histone Hyp	0.520	neurodegeneration	Investigate mechanisms of epigenetic rep
Lamin B1 Restoration Prevents Age-Related Nuclear Lamina Com	0.510	neurodegeneration	Investigate mechanisms of epigenetic rep
DNA Hypomethylation at P2RY12 Promoter Correlates with Disea	0.440	neurodegeneration	What determines P2RY12 receptor expressi
Age-related neuroinflammation mimics early Alzheimer's disea	0.362	Alzheimer's disease	Allen Mouse Brain Aging Atlas: cross-age

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RELA in their description or question text

RELA

Understanding Entity Pages

Summary

Wiki Pages (3)

NF-κB p65 Protein

RELA (p65) Protein

RELA (NF-κB p65)

Pathway Diagram

Outgoing (471)

Incoming (281)

Targeting Hypotheses (9)

Mentioning Analyses (0)

Experiments (0)

Related Papers (0)

Debates (0)

Related Research

HDAC1/2 Complex Restoration Corrects Age-Related Histone Hypoacetylation

Lamin B1 Restoration Prevents Age-Related Nuclear Lamina Compromise

DNA Hypomethylation at P2RY12 Promoter Correlates with Disease Progression

Age-related neuroinflammation mimics early Alzheimer's disease pathology