| Gene Symbol | CCND1 |
| Aliases | Cyclin D1 |
| Primary Expression | Hippocampus |
| Subcellular Localization | </th><td>Nucleus, Cytoplasm</td></tr> |
| Molecular Weight | 34 kDa |
| Amino Acids | 100 aa |
| Pathways | Autophagy, Wnt, Mtor, Nf-Κb, Pi3K/Akt |
| GeneCards | CCND1 |
| Human Protein Atlas | CCND1 |
| N-terminal region | Required for CDK binding and activation |
| Cyclin box domain | Conserved 100 amino acid sequence that binds CDKs (especially CDK4 and CDK6) |
| C-terminal region | Contains degron sequences for protein turnover |
| PEST sequences | Rich in proline, glutamic acid, serine, threonine |
| Re-expression in AD neurons | Aberrant cell cycle entry in vulnerable neurons [1] |
| [Tau](/proteins/tau) phosphorylation | Interaction with CDK4/6 promotes tau pathology [2] |
| Associated Diseases | ALS, Cancer, Carcinoma |
| Known Drugs/Compounds | rapamycin |
| Interactions | AKT, AMPK, APC, APOPTOSIS, ATG, AXIN1 |
| KG Connections | 397 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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