concept

AKT1S1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AKT1S1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

186Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

AKT1S1 is a concept in neurodegeneration research. Key relationships include: interacts with, regulates, expressed in. Associated with ALS, Cancer, Fibrosis. Connected to 78 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	AKT1S1
Key Genes/Proteins	Actin, Akt, AKT1, AMBRA1, AMPK, APC
Related Diseases	Als, ALS
Related Pathways	apoptosis pathway, Autophagy

Pathway Diagram

graph TD
    AKT1S1["AKT1S1"]
    AKT1S1 -->|"regulates"| Fibrosis["Fibrosis"]
    AKT1S1 -->|"interacts"| ALS["ALS"]
    AKT1S1 -->|"interacts"| Cancer["Cancer"]
    AKT1S1 -->|"regulates"| ROS["ROS"]
    AKT1S1 -->|"interacts"| HMGB1["HMGB1"]
    AKT1S1 -->|"regulates"| ATG16L1["ATG16L1"]
    AKT1S1 -->|"interacts"| EGF["EGF"]
    AKT1S1 -->|"interacts"| NBR1["NBR1"]
    AKT1S1 -->|"interacts"| RPS6KB1["RPS6KB1"]
    AKT1S1 -->|"interacts"| MLST8["MLST8"]
    SLC39A8["SLC39A8"] -->|"regulates"| AKT1S1
    STAT3["STAT3"] -->|"interacts"| AKT1S1
    EGFR["EGFR"] -->|"interacts"| AKT1S1
    DEPTOR["DEPTOR"] -->|"interacts"| AKT1S1
    MLKL["MLKL"] -->|"interacts"| AKT1S1
    RAS["RAS"] -->|"interacts"| AKT1S1
    EIF2A["EIF2A"] -->|"interacts"| AKT1S1
    RB1CC1["RB1CC1"] -->|"interacts"| AKT1S1
    GABARAP["GABARAP"] -->|"interacts"| AKT1S1
    AMBRA1["AMBRA1"] -->|"regulates"| AKT1S1

Outgoing (98)

Target	Relation	Type	Str
Als	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Fibrosis	regulates	disease	0.65
MLKL	interacts_with	gene	0.60
ATP	regulates	gene	0.60
CANCER	interacts_with	gene	0.60
GABARAP	interacts_with	gene	0.60
AMBRA1	activates	gene	0.60
AMPK	activates	gene	0.60
APC	activates	gene	0.60
ATF6	activates	gene	0.60
ATG	activates	gene	0.60
ATP	activates	gene	0.60
BECN1	activates	gene	0.60
CALCOCO2	activates	gene	0.60
CASP3	activates	gene	0.60
CDH1	activates	gene	0.60
CFTR	activates	gene	0.60
CGAS	activates	gene	0.60
WNT	activates	gene	0.60
apoptosis pathway	participates_in	pathway	0.60
MAPK signaling	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
Wnt	regulates	pathway	0.60
AUTOPHAGY	regulates	gene	0.60
CLDN2	activates	gene	0.60
Actin	regulates	protein	0.60
Akt	regulates	protein	0.60
NBR1	interacts_with	gene	0.60
Oxidative Phosphorylation	interacts_with	pathway	0.60
Autophagy	regulates	pathway	0.60
RIPK1	interacts_with	gene	0.60
CFTR	regulates	gene	0.60
IFNG	interacts_with	gene	0.60
MTORC1	interacts_with	gene	0.60
JNK	regulates	gene	0.60
HSP70	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
P38	interacts_with	protein	0.60
Caspase	regulates	protein	0.60
Rb	interacts_with	protein	0.60
RPS6KB1	interacts_with	gene	0.60
MLST8	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
AMPK	regulates	gene	0.60
TFEB	interacts_with	gene	0.60
GABA	interacts_with	gene	0.60
ATG	regulates	gene	0.60

Incoming (88)

Source	Relation	Type	Str
SLC39A8	regulates	gene	0.70
WNT	regulates	gene	0.60
EGF	interacts_with	gene	0.60
NLR	interacts_with	gene	0.60
HMGB1	interacts_with	gene	0.60
MLST8	interacts_with	gene	0.60
ROS	regulates	gene	0.60
MAPK	interacts_with	gene	0.60
NRBF2	interacts_with	gene	0.60
GCN2	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
RHEB	interacts_with	gene	0.60
CASP3	regulates	gene	0.60
STAT3	interacts_with	gene	0.60
EGFR	interacts_with	gene	0.60
DEPTOR	interacts_with	gene	0.60
MLKL	interacts_with	gene	0.60
RAS	interacts_with	gene	0.60
EIF2A	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
GABARAP	interacts_with	gene	0.60
AMBRA1	regulates	gene	0.60
MAVS	interacts_with	gene	0.60
ATF6	regulates	gene	0.60
LRRK2	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
GRB2	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
CALCOCO2	regulates	gene	0.60
PIK3C3	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60
CFTR	regulates	gene	0.60
CGAS	regulates	gene	0.60
PPARG	interacts_with	gene	0.60
OPTINEURIN	interacts_with	gene	0.60
AUTOPHAGY	regulates	gene	0.60
FIP200	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
P38	interacts_with	gene	0.60
MTORC1	interacts_with	gene	0.60
ATG	regulates	gene	0.60
DDIT3	interacts_with	gene	0.60
JNK	regulates	gene	0.60
RIPK1	interacts_with	gene	0.60
AMPK	regulates	gene	0.60
LYSOSOME	interacts_with	gene	0.60
APC	regulates	gene	0.60
DNA	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning AKT1S1 in their description or question text

No additional research found