pathway

OXIDATIVE PHOSPHORYLATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OXIDATIVE PHOSPHORYLATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1299Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

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🔀 Pathway Info

Name	OXIDATIVE PHOSPHORYLATION
Key Genes/Proteins	ABCA7, AKT1, ALPHA-SYNUCLEIN, AMPK, AMYLOID, APOE
Related Diseases	ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS, APOPTOSIS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Oxidative Phosphorylation (OXPHOS)

pathway · 635 words

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Pathway Diagram

graph TD
    OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"] -->|"activates"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    style OXIDATIVE_STRESS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"] -->|"activates"| TCA_CYCLE["TCA CYCLE"]
    style TCA_CYCLE fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"] -->|"activates"| PI3K["PI3K"]
    style PI3K fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"] -->|"activates"| RAS["RAS"]
    style RAS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"] -->|"activates"| RB1["RB1"]
    style RB1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"] -->|"activates"| RIPK1["RIPK1"]
    style RIPK1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"] -->|"activates"| SQSTM1["SQSTM1"]
    style SQSTM1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    COMPLEMENT["COMPLEMENT"] -->|"activates"| OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"]
    style COMPLEMENT fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    IMMUNE_RESPONSE["IMMUNE RESPONSE"] -->|"activates"| OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"]
    style IMMUNE_RESPONSE fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    DENDRITIC_CELL["DENDRITIC CELL"] -->|"activates"| OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"]
    style DENDRITIC_CELL fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    DNA_DAMAGE["DNA DAMAGE"] -->|"activates"| OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"]
    style DNA_DAMAGE fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    EGF["EGF"] -->|"activates"| OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"]
    style EGF fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style OXIDATIVE_PHOSPHORYLATION fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (189)

Target	Relation	Type	Str
Chronic Tendon Injury	therapeutic_target	disease	0.95
Tendon Homeostasis	associated_with	process	0.90
Lung Cancer Brain Metastasis	involved_in	disease	0.90
LIPID DROPLET ACCUMULATION	inhibits	phenotype	0.90
Necroptosis	suppresses	process	0.85
Ovarian Cancer	downregulates	disease	0.75
aging	associated_with	phenotype	0.75
BMAL1	regulates	gene	0.70
PYROPTOSIS	inhibits	phenotype	0.65
MICROGLIA	treats	cell_type	0.65
SQSTM1	phosphorylates	gene	0.65
PYROPTOSIS	activates	phenotype	0.65
PYRUVATE	activates	phenotype	0.65
CYTOKINES	interacts_with	phenotype	0.65
NECROPTOSIS	causes	phenotype	0.65
ASTROCYTES	produces	cell_type	0.60
Akt	interacts_with	pathway	0.55
Mtor	interacts_with	pathway	0.55
Glycolysis	interacts_with	pathway	0.55
Wnt	interacts_with	pathway	0.55
Nf-Κb	interacts_with	pathway	0.55
Mapk	interacts_with	pathway	0.55
Autophagy	interacts_with	pathway	0.55
Pi3K	interacts_with	pathway	0.55
CELL PROLIFERATION	activates	concept	0.50
Fibroblast	associated_with	cell_type	0.50
Macrophage	associated_with	cell_type	0.50
AXON	causes	concept	0.50
Macrophage	activates	cell_type	0.50
Macrophage	therapeutic_target	cell_type	0.50
GLYCOLYSIS	associated_with	pathway	0.50
Monocyte	associated_with	cell_type	0.50
Epithelial	interacts_with	cell_type	0.50
NEURONS	regulates	concept	0.50
Dendritic Cell	interacts_with	cell_type	0.50
Stem Cell	interacts_with	cell_type	0.50
GLYCOLYSIS	regulates	pathway	0.50
Astrocyte	associated_with	cell_type	0.50
Reactive Oxygen Species	inhibits	process	0.50
AMYGDALA	expressed_in	concept	0.50
Oligodendrocyte	activates	cell_type	0.50
Neuron	therapeutic_target	cell_type	0.50
Mitochondrial Function	associated_with	pathway	0.50
Proteins	causes	protein	0.50
T Cell	causes	cell_type	0.50
T Cell	activates	cell_type	0.50
Endothelial	activates	cell_type	0.50
Fibroblast	inhibits	cell_type	0.50
T Cell	inhibits	cell_type	0.50
T Cell	therapeutic_target	cell_type	0.50

Incoming (1110)

Source	Relation	Type	Str
APOPTOSIS	regulates	gene	1.00
Cancer	regulates	disease	1.00
OXIDATIVE STRESS	activates	gene	1.00
ROS	activates	gene	1.00
Tumor	therapeutic_target	disease	1.00
Inflammation	activates	disease	1.00
Als	therapeutic_target	disease	1.00
Als	activates	disease	1.00
AKT	activates	gene	1.00
PI3K	activates	gene	1.00
CANCER	activates	gene	1.00
Cancer	therapeutic_target	disease	1.00
MITOCHONDRIAL DYSFUNCTION	activates	gene	1.00
Als	regulates	disease	1.00
Tumor	activates	disease	1.00
Tumor	inhibits	disease	1.00
CANCER	regulates	gene	1.00
Cancer	activates	disease	1.00
CANCER	therapeutic_target	gene	1.00
ATP	associated_with	gene	1.00
Inflammation	regulates	disease	1.00
ATP	activates	gene	1.00
MITOCHONDRIA	associated_with	gene	1.00
MITOPHAGY	regulates	gene	1.00
CANCER	inhibits	gene	1.00
MITOCHONDRIAL DYSFUNCTION	treats	gene	1.00
INFLAMMATION	regulates	gene	1.00
Obesity	activates	disease	1.00
GENES	activates	gene	1.00
MTOR	activates	gene	1.00
Gamitrinib	inhibits	drug	0.95
Astrocytic Mitochondria	involved_in	cell_type	0.95
PPARGC1A	mediates	gene	0.95
mtDNA	involved_in	biomarker	0.95
MITOCHONDRIA	associated_with	cell_type	0.95
Mtdna	associated_with	biomarker	0.95
Tumor	regulates	disease	0.95
Inflammasome	downregulates	process	0.95
COX6B1	activates	protein	0.90
PPARGC1A	associated_with	gene	0.90
MT-ND1	involved_in	gene	0.90
COX4I1	involved_in	gene	0.90
Early Metastatic Epithelial Cell Clusters	involved_in	cell_type	0.90
Mitochondrial Genome	associated_with	biomarker	0.90
COX15	involved_in	gene	0.90
NDUFA12	involved_in	gene	0.90
MITOPHAGY	activates	gene	0.90
Als	causes	disease	0.90
MITOCHONDRIA	activates	gene	0.90
Aging	activates	disease	0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Which specific metabolic pathways in APOE4+ microglia are most therapeutically t

neurodegeneration | 2026-04-08 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

While APOE4 disrupts microglial metabolism broadly, the debate didn't identify w

closed · Rounds: 4 · Score: 0.92 · 2026-04-09

Related Research

Hypotheses and analyses mentioning OXIDATIVE PHOSPHORYLATION in their description or question text

No additional research found