concept

CLDN2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CLDN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

56Connections

0Hypotheses

0Analyses

37Outgoing

19Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CLDN2
Key Genes/Proteins	AKT1, AKT1S1, AMBRA1, AMPK, APC, ASC
Related Pathways	apoptosis pathway, autophagy pathway

Pathway Diagram

graph TD
    CLDN2[CLDN2]
    CLDN2 -->|participates in| MAPK_signaling[MAPK signaling]
    CLDN2 -->|activates| ERN1[ERN1]
    CLDN2 -->|activates| IRGM1[IRGM1]
    CLDN2 -->|activates| LC3[LC3]
    CLDN2 -->|activates| MELK[MELK]
    CLDN2 -->|activates| MTOR[MTOR]
    CLDN2 -->|activates| NLRP3[NLRP3]
    CLDN2 -->|activates| NOD2[NOD2]
    CLDN2 -->|activates| PI3K[PI3K]
    CLDN2 -->|activates| PYCARD[PYCARD]
    AKT1[AKT1] -->|activates| CLDN2
    AMBRA1[AMBRA1] -->|activates| CLDN2
    APC[APC] -->|activates| CLDN2
    ATF6[ATF6] -->|activates| CLDN2
    BECN1[BECN1] -->|activates| CLDN2
    CALCOCO2[CALCOCO2] -->|activates| CLDN2
    CASP3[CASP3] -->|activates| CLDN2
    CFTR[CFTR] -->|activates| CLDN2
    CGAS[CGAS] -->|activates| CLDN2
    ASC[ASC] -->|activates| CLDN2

Outgoing (37)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:CLDN2	data_in	dataset_row	0.00
MAPK signaling	participates_in	pathway	0.70
ROS	activates	gene	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
apoptosis pathway	participates_in	pathway	0.60
IKK	activates	gene	0.60
MAP1LC3	activates	gene	0.60
MAPK	activates	gene	0.60
NLR	activates	gene	0.60
NRBF2	activates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
necroptosis	participates_in	pathway	0.60
cancer	activates	disease	0.60
WNT	activates	gene	0.60
CRC	associated_with	disease	0.60
ERN1	activates	gene	0.60
IRGM1	activates	gene	0.60
LC3	activates	gene	0.60
MELK	activates	gene	0.60
MTOR	activates	gene	0.60
NLRP3	activates	gene	0.60
NOD2	activates	gene	0.60
PI3K	activates	gene	0.60
PYCARD	activates	gene	0.60
RALGAPA2	activates	gene	0.60
RIPK2	activates	gene	0.60
RIPK3	activates	gene	0.60
SMARCA4	activates	gene	0.60
SNF	activates	gene	0.60
SQSTM1	activates	gene	0.60
STAT3	activates	gene	0.60
SWI	activates	gene	0.60
TNF	activates	gene	0.60
TNFA	activates	gene	0.60
ULK1	activates	gene	0.60
stem cells	expressed_in	cell_type	0.55

Incoming (19)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:CLDN2	data_in	dataset_row	0.00
AKT1S1	activates	gene	0.60
AMPK	activates	gene	0.60
ATG	activates	gene	0.60
CDH1	activates	gene	0.60
CCDC50	activates	gene	0.60
rapamycin	targets	drug	0.60
ATP	activates	gene	0.60
AKT1	activates	gene	0.60
AMBRA1	activates	gene	0.60
APC	activates	gene	0.60
ATF6	activates	gene	0.60
BECN1	activates	gene	0.60
CALCOCO2	activates	gene	0.60
CASP3	activates	gene	0.60
CFTR	activates	gene	0.60
CGAS	activates	gene	0.60
ASC	activates	gene	0.60
BRG1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CLDN2 in their description or question text

No additional research found