gene

RPTOR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RPTOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

463Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Page for RPTOR — Regulatory Associated Protein of MTOR Complex 1

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🧬 Gene Info

Gene Symbol	RPTOR
Full Name	Regulatory Associated Protein of MTOR Complex 1
Chromosome	17q25.3.
Function	is an essential scaffolding component of the mTOR Complex 1 (mTORC1), located on chromosome 17q25.
Primary Expression	Hippocampus, Cortex, Cerebellum, Substantia nigra (ubiquitous)
Amino Acids	335 aa
Exons	30
Pathways	MTOR, mTOR, AMPK, mtor, mTOR pathway
UniProt ID	Q8N122
NCBI Gene ID	57521
Ensembl ID	ENSG00000141564
OMIM	607592
GeneCards	RPTOR
Human Protein Atlas	RPTOR
[TFEB](/genes/tfeb) binding sites	Lysosomal stress induces RPTOR transcription through a TFEB-dependent feedback loop
Associated Diseases	Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, Tuberous Sclerosis
Known Drugs/Compounds	rapamycin
Interactions	ACOX1, Actin, Adiponectin, ADIPOQ, AKT1, AKT1S1
KG Connections	463 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RPTOR — AlphaFold Q8N122 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

RPTOR — Regulatory Associated Protein of MTOR Complex 1

gene · 1315 words

→

RPTOR Protein

protein · 636 words

→

Pathway Diagram

graph TD
    RPTOR["RPTOR"] -->|"Interacts With"| Cancer["Cancer"]
    RPTOR["RPTOR"] -->|"Interacts With"| Als["Als"]
    RPTOR["RPTOR"] -->|"Interacts With"| Ms["Ms"]
    RPTOR["RPTOR"] -->|"Interacts With"| Fibrosis["Fibrosis"]
    RPTOR["RPTOR"] -->|"Interacts With"| Tumor["Tumor"]
    RPTOR["RPTOR"] -->|"Interacts With"| Hepatitis["Hepatitis"]
    RPTOR["RPTOR"] -->|"Interacts With"| RB1["RB1"]
    RPTOR["RPTOR"] -->|"Interacts With"| EIF2AK3["EIF2AK3"]
    OPTN["OPTN"] -->|"Interacts With"| RPTOR["RPTOR"]
    CASP3["CASP3"] -->|"Interacts With"| RPTOR["RPTOR"]
    AKT1["AKT1"] -->|"Interacts With"| RPTOR["RPTOR"]
    CALCOCO2["CALCOCO2"] -->|"Interacts With"| RPTOR["RPTOR"]
    CGAS["CGAS"] -->|"Interacts With"| RPTOR["RPTOR"]
    style RPTOR fill:#8d4900,color:#e0e0e0
    style Cancer fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Fibrosis fill:#b71c1c,color:#e0e0e0
    style Tumor fill:#b71c1c,color:#e0e0e0
    style Hepatitis fill:#b71c1c,color:#e0e0e0
    style RB1 fill:#8d4900,color:#e0e0e0
    style EIF2AK3 fill:#8d4900,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style CASP3 fill:#8d4900,color:#e0e0e0
    style AKT1 fill:#8d4900,color:#e0e0e0
    style CALCOCO2 fill:#8d4900,color:#e0e0e0
    style CGAS fill:#8d4900,color:#e0e0e0

Outgoing (242)

Target	Relation	Type	Str
MTOR	component_of	protein	0.95
MTOR	binds	protein	0.90
MTORC1	regulates	entity	0.90
MTORC1	component_of	entity	0.90
S6K1	regulates	protein	0.80
cell size	regulates	phenotype	0.80
MTOR	inhibits	protein	0.80
autophagy pathway	participates_in	pathway	0.70
ALS	interacts_with	disease	0.65
ALS	regulates	disease	0.65
Ms	contributes_to	disease	0.65
Tumor	interacts_with	disease	0.65
Hepatitis	interacts_with	disease	0.65
Alzheimer	regulates	disease	0.65
Als	interacts_with	disease	0.65
Fibrosis	regulates	disease	0.65
Als	regulates	disease	0.65
Ms	interacts_with	disease	0.65
Fibrosis	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Wnt	regulates	pathway	0.60
LYSOSOME	interacts_with	gene	0.60
AKT1S1	interacts_with	gene	0.60
ROS	interacts_with	gene	0.60
ATG16L1	interacts_with	gene	0.60
RHEB	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
STAT3	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
CFTR	interacts_with	gene	0.60
SIRT1	activates	entity	0.60
STAT3	activates	gene	0.60
SQSTM1	activates	entity	0.60
SREBF1	activates	entity	0.60
SIRT3	activates	entity	0.60
complement cascade	participates_in	pathway	0.60
phagocytosis	activates	process	0.60
Autophagy	interacts_with	pathway	0.60
Mapk	interacts_with	pathway	0.60
Pi3K	interacts_with	pathway	0.60
Akt	interacts_with	pathway	0.60
Oxidative Phosphorylation	interacts_with	pathway	0.60
Wnt	interacts_with	pathway	0.60
Akt	regulates	pathway	0.60
Adiponectin	interacts_with	protein	0.60
NBR1	interacts_with	gene	0.60
HSP70	interacts_with	gene	0.60
TFE3	interacts_with	gene	0.60

Incoming (221)

Source	Relation	Type	Str
RRAGA	binds	gene	0.90
EP300	phosphorylates	protein	0.85
P300	phosphorylates	protein	0.80
TARDBP	regulates	gene	0.80
rapamycin	targets	drug	0.70
MTORC1	activates	gene	0.70
CREB	interacts_with	gene	0.60
CYP1A1	activates	gene	0.60
DNA	activates	gene	0.60
GCN2	activates	gene	0.60
IFN	activates	gene	0.60
MAPK	activates	gene	0.60
NLR	activates	gene	0.60
NRBF2	activates	gene	0.60
ROS	activates	gene	0.60
PPARA	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
STX17	interacts_with	gene	0.60
NOS3	interacts_with	gene	0.60
GLP1R	interacts_with	gene	0.60
SREBF1	interacts_with	gene	0.60
SIRT1	interacts_with	gene	0.60
KDM6B	interacts_with	gene	0.60
P38	interacts_with	gene	0.60
PIK3C3	interacts_with	gene	0.60
PHAGOCYTOSIS	interacts_with	gene	0.60
LAMP2	activates	entity	0.60
LC3	activates	entity	0.60
MAP3K5	activates	entity	0.60
MTOR	activates	entity	0.60
NFE2L2	activates	entity	0.60
NOS3	activates	entity	0.60
NR1H3	activates	entity	0.60
P62	activates	entity	0.60
PLIN2	activates	entity	0.60
PLIN3	activates	entity	0.60
PPARA	activates	entity	0.60
PRKAA2	activates	entity	0.60
HTRA2	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
LAMP2	interacts_with	gene	0.60
MTOR	contributes_to	gene	0.60
RICTOR	contributes_to	gene	0.60
PLIN3	interacts_with	gene	0.60
PRKAA2	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RPTOR in their description or question text

No additional research found