protein

SLC39A8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC39A8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

13Connections

0Hypotheses

0Analyses

12Outgoing

1Incoming

0Experiments

0Debates

Summary

SLC39A8 is a protein involved in neurodegeneration research. Key relationships include: regulates, transports, associated with. Associated with inflammatory bowel disease, kidney disease. Connected to 11 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	SLC39A8
Full Name	Solute Carrier Family 39 Member 8
Chromosome	4q24
Protein Type	Transporter
Function	SLC39A8 encodes the zinc and iron transporter protein ZIP8 (also called Zrt- and Irt-like protein 8).
Primary Expression	dopaminergic neurons of the substantia nigra, making it particularly relevant to Parkinson's disease pathogenesis
Amino Acids	462 aa
UniProt ID	[Q9C0K1](https://www.uniprot.org/uniprot/Q9C0K1)
Ensembl ID	ENSG00000138821
OMIM	608732
GeneCards	SLC39A8
Human Protein Atlas	SLC39A8
Zinc transport	ZIP8 mediates cellular zinc uptake, essential for enzyme function, protein structure, and signaling pathways[@liu2023]
Iron homeostasis	The transporter also imports iron, crucial for mitochondrial function and neurotransmitter synthesis[@wang2022]
Blood-brain barrier permeation	SLC39A8 expression on endothelial cells of the BBB allows metal entry into the brain[@gomes2021]
Associated Diseases	ALS, inflammatory bowel disease, kidney disease, neurodegeneration
Interactions	KCNK2
KG Connections	13 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SLC39A8

gene · 528 words

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SLC39A8 Protein

protein · 616 words

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Pathway Diagram

graph TD
    SLC39A8["SLC39A8"]
    Mn["Mn"]
    SLC39A8 -->|"transports"| Mn
    Zn["Zn"]
    SLC39A8 -->|"transports"| Zn
    kidney_disease{"kidney disease"}
    SLC39A8 -->|"associated with"| kidney_disease
    inflammatory_bowel_disease{"inflammatory bowel disease"}
    SLC39A8 -->|"associated with"| inflammatory_bowel_disease
    ACER1["ACER1"]
    SLC39A8 -->|"regulates"| ACER1
    ferroptosis["ferroptosis"]
    SLC39A8 -->|"regulates"| ferroptosis
    AKT1S1["AKT1S1"]
    SLC39A8 -->|"regulates"| AKT1S1
    GABBR2["GABBR2"]
    SLC39A8 -->|"regulates"| GABBR2
    GPR56["GPR56"]
    SLC39A8 -->|"regulates"| GPR56
    TXNDC12["TXNDC12"]
    SLC39A8 -->|"regulates"| TXNDC12
    neurodegeneration["neurodegeneration"]
    SLC39A8 -->|"implicated in"| neurodegeneration
    style SLC39A8 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (12)

Target	Relation	Type	Str
Zn	transports	entity	0.90
Mn	transports	entity	0.90
kidney disease	associated_with	disease	0.90
inflammatory bowel disease	associated_with	disease	0.80
ACER1	regulates	gene	0.80
GPR56	regulates	gene	0.70
GABBR2	regulates	gene	0.70
TXNDC12	regulates	gene	0.70
AKT1S1	regulates	gene	0.70
neurodegeneration	associated_with	disease	0.60
ALS	associated_with	disease	0.60
autophagy pathway	participates_in	pathway	0.60

Incoming (1)

Source	Relation	Type	Str
KCNK2	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SLC39A8 in their description or question text

No additional research found