concept

INTERLEUKIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about INTERLEUKIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

663Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	INTERLEUKIN

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Interleukin-6 (IL-6)

entity · 957 words

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Pathway Diagram

graph TD
    INTERLEUKIN["INTERLEUKIN"]
    style INTERLEUKIN fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    INTERLEUKIN -->|"regulates"| Fibrosis["Fibrosis"]
    INTERLEUKIN -->|"target for"| Als["Als"]
    INTERLEUKIN -->|"interacts"| Cancer["Cancer"]
    INTERLEUKIN -->|"target for"| Multiple_Sclerosis["Multiple Sclerosis"]
    INTERLEUKIN -->|"target for"| Neuroinflammation["Neuroinflammation"]
    REL([REL]) -->|"regulates"| INTERLEUKIN
    IL_10([IL-10]) -->|"activates"| INTERLEUKIN
    CERS2([CERS2]) -->|"regulates"| INTERLEUKIN
    IGF1R([IGF1R]) -->|"regulates"| INTERLEUKIN
    DAG1([DAG1]) -->|"regulates"| INTERLEUKIN
    RNA([RNA]) -->|"regulates"| INTERLEUKIN
    ROS([ROS]) -->|"regulates"| INTERLEUKIN
    HSPG2([HSPG2]) -->|"regulates"| INTERLEUKIN
    RIPK1([RIPK1]) -->|"interacts"| INTERLEUKIN
    PPARG([PPARG]) -->|"interacts"| INTERLEUKIN

Outgoing (189)

Target	Relation	Type	Str
Stroke	activates	disease	0.60
Aging	associated_with	disease	0.60
Alzheimer	therapeutic_target	disease	0.60
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.60
Encephalitis	therapeutic_target	disease	0.60
Alzheimer	activates	disease	0.60
Depression	associated_with	disease	0.60
Neurodegeneration	regulates	disease	0.60
Obesity	activates	disease	0.60
Depression	therapeutic_target	disease	0.60
Epilepsy	therapeutic_target	disease	0.60
Huntington	activates	disease	0.60
Alzheimer	associated_with	disease	0.60
Atherosclerosis	associated_with	disease	0.60
Hypertension	associated_with	disease	0.60
Als	interacts_with	disease	0.60
Neuropathy	expressed_in	disease	0.60
Ferroptosis	activates	disease	0.60
Dementia	causes	disease	0.60
Neurodegeneration	causes	disease	0.60
Als	causes	disease	0.60
Neuroinflammation	causes	disease	0.60
Cancer	activates	disease	0.60
Glioblastoma	activates	disease	0.60
Depression	activates	disease	0.60
Atherosclerosis	activates	disease	0.60
Aging	activates	disease	0.60
Fibrosis	regulates	disease	0.60
Als	therapeutic_target	disease	0.60
Cancer	inhibits	disease	0.60
Leukemia	inhibits	disease	0.60
Aging	therapeutic_target	disease	0.60
Diabetes	activates	disease	0.60
Neuroinflammation	therapeutic_target	disease	0.60
Aging	expressed_in	disease	0.60
Senescence	expressed_in	disease	0.60
Encephalitis	activates	disease	0.60
Frontotemporal Dementia	activates	disease	0.60
Dementia	activates	disease	0.60
Amyotrophic Lateral Sclerosis	activates	disease	0.60
Lymphoma	activates	disease	0.60
Neurodegeneration	associated_with	disease	0.60
Migraine	associated_with	disease	0.60
Ferroptosis	associated_with	disease	0.60
Stroke	regulates	disease	0.60
Epilepsy	activates	disease	0.60
Pyroptosis	causes	disease	0.60
Multiple Sclerosis	therapeutic_target	disease	0.60
Als	expressed_in	disease	0.60
Aging	biomarker_for	disease	0.60

Incoming (474)

Source	Relation	Type	Str
AGING	associated_with	gene	0.60
HSPA1A	associated_with	gene	0.60
VIM	activates	gene	0.60
MITOCHONDRIA	biomarker_for	gene	0.60
PROGRANULIN	activates	gene	0.60
VIMENTIN	activates	gene	0.60
TGM2	activates	gene	0.60
PGRN	activates	gene	0.60
FGF21	activates	gene	0.60
CX3CL1	activates	gene	0.60
AMYLOID	activates	gene	0.60
HMGB1	activates	gene	0.60
PLAU	activates	gene	0.60
GHRL	activates	gene	0.60
APOPTOSIS	biomarker_for	gene	0.60
IGF-1	activates	gene	0.60
CXCL1	regulates	gene	0.60
IL-17	associated_with	gene	0.60
MMP9	regulates	gene	0.60
TNF	regulates	gene	0.60
JUN	regulates	gene	0.60
CXCL8	regulates	gene	0.60
TLR2	regulates	gene	0.60
IL-17	activates	gene	0.60
MMP9	activates	gene	0.60
BAX	activates	gene	0.60
S100A8	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
S100A9	activates	gene	0.60
IL6	expressed_in	gene	0.60
HIF1	inhibits	gene	0.60
HIF1A	inhibits	gene	0.60
AGING	inhibits	gene	0.60
MICRORNAS	inhibits	gene	0.60
MIR-369-3P	inhibits	gene	0.60
P38	contributes_to	gene	0.60
DEMENTIA	causes	gene	0.60
TAU	causes	gene	0.60
ASTROCYTE	contributes_to	gene	0.60
AMYLOID	causes	gene	0.60
ASTROCYTES	contributes_to	gene	0.60
IL-1	causes	gene	0.60
PHAGOCYTOSIS	causes	gene	0.60
GLUT1	activates	gene	0.60
GBM	activates	gene	0.60
PERK	activates	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
P2X7	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
DNAJB9	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning INTERLEUKIN in their description or question text

No additional research found