concept

INTERLEUKIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about INTERLEUKIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

663Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	INTERLEUKIN

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Interleukin-6 (IL-6)

entity · 957 words

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Pathway Diagram

graph TD
    INTERLEUKIN["INTERLEUKIN"]
    style INTERLEUKIN fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    INTERLEUKIN -->|"regulates"| Fibrosis["Fibrosis"]
    INTERLEUKIN -->|"target for"| Als["Als"]
    INTERLEUKIN -->|"interacts"| Cancer["Cancer"]
    INTERLEUKIN -->|"target for"| Multiple_Sclerosis["Multiple Sclerosis"]
    INTERLEUKIN -->|"target for"| Neuroinflammation["Neuroinflammation"]
    REL([REL]) -->|"regulates"| INTERLEUKIN
    IL_10([IL-10]) -->|"activates"| INTERLEUKIN
    CERS2([CERS2]) -->|"regulates"| INTERLEUKIN
    IGF1R([IGF1R]) -->|"regulates"| INTERLEUKIN
    DAG1([DAG1]) -->|"regulates"| INTERLEUKIN
    RNA([RNA]) -->|"regulates"| INTERLEUKIN
    ROS([ROS]) -->|"regulates"| INTERLEUKIN
    HSPG2([HSPG2]) -->|"regulates"| INTERLEUKIN
    RIPK1([RIPK1]) -->|"interacts"| INTERLEUKIN
    PPARG([PPARG]) -->|"interacts"| INTERLEUKIN

Outgoing (189)

Target	Relation	Type	Str
Glioblastoma	activates	disease	0.60
Alzheimer	therapeutic_target	disease	0.60
Dementia	causes	disease	0.60
Cancer	activates	disease	0.60
Depression	activates	disease	0.60
Atherosclerosis	activates	disease	0.60
Aging	biomarker_for	disease	0.60
Atherosclerosis	inhibits	disease	0.60
Neurodegeneration	causes	disease	0.60
Neuroinflammation	causes	disease	0.60
Multiple Sclerosis	therapeutic_target	disease	0.60
Als	therapeutic_target	disease	0.60
Als	activates	disease	0.60
Als	interacts_with	disease	0.60
Aging	therapeutic_target	disease	0.60
Ferroptosis	activates	disease	0.60
Fibrosis	biomarker_for	disease	0.60
Diabetes	inhibits	disease	0.60
Fibrosis	regulates	disease	0.60
Cancer	inhibits	disease	0.60
Als	causes	disease	0.60
Parkinson	activates	disease	0.60
Neuroinflammation	activates	disease	0.60
Stroke	activates	disease	0.60
Neuroinflammation	therapeutic_target	disease	0.60
Als	expressed_in	disease	0.60
Aging	inhibits	disease	0.60
Neurodegeneration	inhibits	disease	0.60
Parkinson	regulates	disease	0.60
Als	inhibits	disease	0.60
Cancer	interacts_with	disease	0.60
Leukemia	inhibits	disease	0.60
Cancer	expressed_in	disease	0.60
Neuropathy	expressed_in	disease	0.60
Fibrosis	interacts_with	disease	0.60
Anxiety	activates	disease	0.60
Als	regulates	disease	0.60
Senescence	biomarker_for	disease	0.60
Pyroptosis	activates	disease	0.60
Multiple Sclerosis	associated_with	disease	0.60
Parkinson	associated_with	disease	0.60
Anxiety	associated_with	disease	0.60
Neuroinflammation	associated_with	disease	0.60
Neurodegeneration	activates	disease	0.60
Aging	associated_with	disease	0.60
Parkinson	expressed_in	disease	0.60
Neuroinflammation	expressed_in	disease	0.60
Cancer	regulates	disease	0.60
Obesity	therapeutic_target	disease	0.60
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.60

Incoming (474)

Source	Relation	Type	Str
TAU	activates	gene	0.60
IL-18	activates	gene	0.60
GSDMD	activates	gene	0.60
GASDERMIN	activates	gene	0.60
POMC	activates	gene	0.60
EGR2	activates	gene	0.60
SIRT6	inhibits	gene	0.60
NAD	inhibits	gene	0.60
CD38	activates	gene	0.60
NAMPT	inhibits	gene	0.60
NEURON	activates	gene	0.60
GPR37	activates	gene	0.60
PARKINSON	activates	gene	0.60
PSAP	activates	gene	0.60
IL6	regulates	gene	0.60
GAPDH	inhibits	gene	0.60
CASP1	inhibits	gene	0.60
ATG5	inhibits	gene	0.60
BECN1	inhibits	gene	0.60
MICROGLIA	inhibits	gene	0.60
UBIQUITIN	regulates	gene	0.60
GFAP	inhibits	gene	0.60
IL1B	regulates	gene	0.60
GFP	inhibits	gene	0.60
PARKINSON	regulates	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
ATG7	inhibits	gene	0.60
NLRP3	regulates	gene	0.60
SNCA	regulates	gene	0.60
AIM2	associated_with	gene	0.60
CASP1	associated_with	gene	0.60
ATG5	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
NLRP3	associated_with	gene	0.60
NLRC4	associated_with	gene	0.60
NLR	associated_with	gene	0.60
ATP	associated_with	gene	0.60
IL18	associated_with	gene	0.60
ASTROCYTES	activates	gene	0.60
TLR4	activates	gene	0.60
ANXIETY	activates	gene	0.60
SNCA	activates	gene	0.60
PARKINSON	associated_with	gene	0.60
ANXIETY	associated_with	gene	0.60
PYROPTOSIS	activates	gene	0.60
PIEZO1	regulates	gene	0.60
PIEZO	regulates	gene	0.60
VIM	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning INTERLEUKIN in their description or question text

No additional research found