gene

MAPK14

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAPK14: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

729Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

MAPK14 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, therapeutic target, activates. Associated with ALS, Aging, Als. Connected to 306 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MAPK14
Full Name	Mitogen-Activated Protein Kinase 14 (p38α)
Chromosome	6p21.3
Protein Type	Serine/Threonine Kinase
Function	is a serine/threonine kinase belonging to the MAPK family.
Molecular Weight	41 kDa
Amino Acids	360 aa
Pathways	MAPK, TGF-β
UniProt ID	[Q16539](https://www.uniprot.org/uniprot/Q16539)
Ensembl ID	ENSG00000166401
OMIM	600289
GeneCards	MAPK14
Human Protein Atlas	MAPK14
Associated Diseases	Aging, Als, Cancer, Cardiovascular, Ischemia, Ms
Known Drugs/Compounds	Losmapimod, rapamycin
Interactions	AIFM1, AKT1, AKT1S1, ALZHEIMER, AMBRA1, AMPK
KG Connections	729 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

MAPK14 — Mitogen-Activated Protein Kinase 14 (p38α)

gene · 1381 words

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MAPK14 Protein

protein · 911 words

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Pathway Diagram

graph TD
    MAPK14["MAPK14"] -->|"Inhibits"| TTP["TTP"]
    MAPK14["MAPK14"] -->|"Interacts With"| Cancer["Cancer"]
    MAPK14["MAPK14"] -->|"Interacts With"| Als["Als"]
    MAPK14["MAPK14"] -->|"Interacts With"| Ms["Ms"]
    MAPK14["MAPK14"] -->|"Interacts With"| Fibrosis["Fibrosis"]
    MAPK14["MAPK14"] -->|"Therapeutic Target"| Osteoporosis["Osteoporosis"]
    MAPK14["MAPK14"] -->|"Interacts With"| BECN1["BECN1"]
    MAPK14["MAPK14"] -->|"Interacts With"| ATF6["ATF6"]
    OPTN["OPTN"] -->|"Interacts With"| MAPK14["MAPK14"]
    CASP3["CASP3"] -->|"Interacts With"| MAPK14["MAPK14"]
    AKT1["AKT1"] -->|"Interacts With"| MAPK14["MAPK14"]
    CALCOCO2["CALCOCO2"] -->|"Interacts With"| MAPK14["MAPK14"]
    CGAS["CGAS"] -->|"Interacts With"| MAPK14["MAPK14"]
    style MAPK14 fill:#8d4900,color:#e0e0e0
    style TTP fill:#0d47a1,color:#e0e0e0
    style Cancer fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Fibrosis fill:#b71c1c,color:#e0e0e0
    style Osteoporosis fill:#b71c1c,color:#e0e0e0
    style BECN1 fill:#8d4900,color:#e0e0e0
    style ATF6 fill:#8d4900,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style CASP3 fill:#8d4900,color:#e0e0e0
    style AKT1 fill:#8d4900,color:#e0e0e0
    style CALCOCO2 fill:#8d4900,color:#e0e0e0
    style CGAS fill:#8d4900,color:#e0e0e0

Outgoing (415)

Target	Relation	Type	Str
TDP-43 Phosphorylation	phosphorylates	process	0.95
TDP-43 Proteinopathy	contributes_to	disease	0.95
TTP	inhibits	protein	0.90
Neurodegeneration	involved_in	process	0.90
MAPT	phosphorylates	protein	0.90
ER Stress Response	mediates	process	0.87
Neuroinflammation	involved_in	process	0.85
Osteoclast Differentiation	involved_in	process	0.85
Autophagy	inhibits	process	0.85
TNF Signaling Pathway	component_of	pathway	0.85
DUX4	regulates	gene	0.85
Tau Phosphorylation	mediates	process	0.85
MAPK signaling	participates_in	pathway	0.80
cellular senescence	regulates	process	0.80
Mapk	therapeutic_target	pathway	0.70
Q16539	activates	protein	0.70
GENES	biomarker_for	gene	0.70
Mapk	regulates	pathway	0.70
Neurodegeneration	therapeutic_target	disease	0.65
Ms	inhibits	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Ms	regulates	disease	0.65
Ischemia	associated_with	disease	0.65
Inflammation	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Osteoporosis	therapeutic_target	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Als	associated_with	disease	0.65
Als	interacts_with	disease	0.65
Als	regulates	disease	0.65
Cardiovascular	associated_with	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Cancer	interacts_with	disease	0.65
ALS	expressed_in	disease	0.65
Fibrosis	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Fibrosis	regulates	disease	0.65
Ms	associated_with	disease	0.65
Infection	activates	disease	0.65
Aging	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Sepsis	regulates	disease	0.65
Sepsis	activates	disease	0.65
ALS	interacts_with	disease	0.65
Als	biomarker_for	disease	0.65

Incoming (314)

Source	Relation	Type	Str
h-ccc05373	targets_gene	hypothesis	0.90
MKK6	activates	protein	0.90
KDEL	activates	receptor	0.90
Losmapimod	inhibits	drug	0.90
Cholix	phosphorylates	entity	0.85
SRC	interacts_with	gene	0.80
MMP9	therapeutic_target	gene	0.70
IL1B	targets	gene	0.70
TNF	therapeutic_target	gene	0.70
AKT1	targets	gene	0.70
TAB1	activates	protein	0.70
OPTN	interacts_with	gene	0.60
CASP3	interacts_with	gene	0.60
AKT1	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
CGAS	interacts_with	gene	0.60
CFTR	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
RPS6KB1	interacts_with	gene	0.60
GRB2	interacts_with	gene	0.60
RHEB	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
ATF6	interacts_with	gene	0.60
HSPA5	interacts_with	gene	0.60
DNA	regulates	gene	0.60
IL1B	activates	gene	0.60
PPARG	interacts_with	gene	0.60
UBIQUITIN	activates	gene	0.60
PIK3C3	activates	gene	0.60
P62	activates	gene	0.60
TSC1	contributes_to	gene	0.60
CREB3	contributes_to	gene	0.60
ATP1A1	contributes_to	gene	0.60
PRDX6	contributes_to	gene	0.60
YWHAZ	contributes_to	gene	0.60
FOS	contributes_to	gene	0.60
IL6	associated_with	gene	0.60
APC	interacts_with	gene	0.60
TXN	regulates	gene	0.60
AKT1	activates	gene	0.60
CASP8	activates	gene	0.60
P38	activates	gene	0.60
GABA	regulates	gene	0.60
IFN	regulates	gene	0.60
CTSD	activates	gene	0.60
GAPDH	activates	gene	0.60
LAMP1	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
ATG5	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MAPK14 in their description or question text

No additional research found