concept

CASPASE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CASPASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

809Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CASPASE

Pathway Diagram

graph TD
    CASPASE["CASPASE"]
    style CASPASE fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    CASPASE -->|"activates"| PANoptosis["PANoptosis"]
    CASPASE -->|"cleaves"| GSDME([GSDME])
    CASPASE -->|"activates"| neurodegeneration["neurodegeneration"]
    CASPASE -->|"activates"| IL1B([IL1B])
    CASPASE -->|"regulates"| Fibrosis["Fibrosis"]
    CASPASE -->|"interacts"| Cancer["Cancer"]
    CASPASE -->|"interacts"| Als["Als"]
    CASPASE -.->|"inhibits"| Aging["Aging"]
    RIPK1([RIPK1]) -->|"interacts"| CASPASE
    PPARG([PPARG]) -->|"interacts"| CASPASE
    WNT([WNT]) -->|"regulates"| CASPASE
    TFEB([TFEB]) -->|"interacts"| CASPASE
    CFTR([CFTR]) -->|"regulates"| CASPASE
    RICTOR([RICTOR]) -->|"interacts"| CASPASE
    ROS([ROS]) -->|"regulates"| CASPASE
    GRB2([GRB2]) -->|"interacts"| CASPASE
    HSP70([HSP70]) -->|"interacts"| CASPASE
    STAT3([STAT3]) -->|"interacts"| CASPASE

Outgoing (207)

Target	Relation	Type	Str
PANoptosis	activates	process	0.92
neurodegeneration	activates	process	0.70
Traumatic Brain Injury	inhibits	disease	0.60
Alzheimer	associated_with	disease	0.60
Cancer	interacts_with	disease	0.60
Als	interacts_with	disease	0.60
Cancer	expressed_in	disease	0.60
Ischemia	inhibits	disease	0.60
Retinopathy	associated_with	disease	0.60
Cardiomyopathy	associated_with	disease	0.60
Huntington	expressed_in	disease	0.60
Alzheimer	expressed_in	disease	0.60
Hypertension	inhibits	disease	0.60
Diabetes	inhibits	disease	0.60
Cardiomyopathy	inhibits	disease	0.60
Depression	interacts_with	disease	0.60
Lymphoma	phosphorylates	disease	0.60
Multiple Sclerosis	activates	disease	0.60
Neurodegeneration	activates	disease	0.60
Glioblastoma	activates	disease	0.60
Alzheimer	inhibits	disease	0.60
Stroke	regulates	disease	0.60
Anxiety	inhibits	disease	0.60
Parkinson	expressed_in	disease	0.60
Stroke	activates	disease	0.60
Aging	associated_with	disease	0.60
Neurodegeneration	protects_against	disease	0.60
Necroptosis	protects_against	disease	0.60
Parkinson	protects_against	disease	0.60
Als	protects_against	disease	0.60
Schizophrenia	expressed_in	disease	0.60
Anxiety	expressed_in	disease	0.60
Depression	expressed_in	disease	0.60
Neuropathy	activates	disease	0.60
Necroptosis	associated_with	disease	0.60
Dementia	inhibits	disease	0.60
Als	regulates	disease	0.60
Neuroinflammation	associated_with	disease	0.60
Pyroptosis	causes	disease	0.60
Pyroptosis	interacts_with	disease	0.60
Necroptosis	activates	disease	0.60
Diabetes	activates	disease	0.60
Obesity	activates	disease	0.60
Pyroptosis	therapeutic_target	disease	0.60
Necroptosis	therapeutic_target	disease	0.60
Vascular Dementia	therapeutic_target	disease	0.60
Ferroptosis	activates	disease	0.60
Neurodegeneration	associated_with	disease	0.60
Pyroptosis	associated_with	disease	0.60
Cancer	associated_with	disease	0.60

Incoming (602)

Source	Relation	Type	Str
MICROGLIA	associated_with	gene	0.60
ASTROCYTES	associated_with	gene	0.60
CYTOKINES	associated_with	gene	0.60
IL-1	associated_with	gene	0.60
VIM	regulates	gene	0.60
WT1	regulates	gene	0.60
LAMP1	regulates	gene	0.60
OCLN	regulates	gene	0.60
ATG14	associated_with	gene	0.60
VIMENTIN	regulates	gene	0.60
HDAC6	regulates	gene	0.60
TUBULIN	regulates	gene	0.60
MAP3K5	regulates	gene	0.60
TJP1	regulates	gene	0.60
GJA1	associated_with	gene	0.60
ACTB	associated_with	gene	0.60
H2AX	associated_with	gene	0.60
RAC1	regulates	gene	0.60
BECN1	associated_with	gene	0.60
CASPASE8	associated_with	gene	0.60
EHMT2	associated_with	gene	0.60
BAX	associated_with	gene	0.60
CASPASE3	associated_with	gene	0.60
APOPTOSIS	inhibits	gene	0.60
FOXO1	associated_with	gene	0.60
JUN	inhibits	gene	0.60
BCL-2	associated_with	gene	0.60
KLK7	activates	gene	0.60
NEURON	activates	gene	0.60
GSDMD	activates	gene	0.60
IL-18	activates	gene	0.60
POLE	activates	gene	0.60
PARKINSON	activates	gene	0.60
ATP	activates	gene	0.60
TREM2	activates	gene	0.60
IBA1	activates	gene	0.60
P38	contributes_to	gene	0.60
DEMENTIA	causes	gene	0.60
TAU	causes	gene	0.60
ASTROCYTE	contributes_to	gene	0.60
MAPK	contributes_to	gene	0.60
AMYLOID	causes	gene	0.60
IL-1	causes	gene	0.60
PHAGOCYTOSIS	causes	gene	0.60
DEMENTIA	activates	gene	0.60
TDP-43	activates	gene	0.60
ALS	activates	gene	0.60
GASDERMIN	activates	gene	0.60
SOD1	activates	gene	0.60
ALZHEIMER	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
NLRP3 Inflammasome Suppression via Selective Caspase-1 Inhib	0.105	neurodegeneration	Neuroinflammation Biomarker Panel for Ea

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CASPASE in their description or question text

No additional research found