gene 849 words KG: FUNDC1
Contents

FUNDC1 — FUN14 Domain Containing 1

🧬 Gene Info
Gene SymbolFUNDC1
Full NameFUN14 Domain Containing 1
Chromosome5q33.2
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight17 kDa
Amino Acids156 aa
PathwaysApoptosis, Autophagy, Ferroptosis, Lipid Metabolism, Metastasis
UniProt IDQ8IWV1
NCBI Gene ID87178
Ensembl IDENSG00000077616
OMIM606467
GeneCardsFUNDC1
Human Protein AtlasFUNDC1
Associated DiseasesAD, ALI, Als, Alzheimer, Alzheimer's disease
InteractionsABCD3, Actin, ALS, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE
KG Connections929 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (13)

Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
Phase-Separated Organelle Targeting
Score: 0.73
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Stress Granule Phase Separation Modulators
Score: 0.72
Autophagosome Maturation Checkpoint Control
Score: 0.71
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
RNA Granule Nucleation Site Modulation
Score: 0.66
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62
PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor
Score: 0.53

Related Analyses (11)

Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (8)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
ABCD3 Gene
gene · KG edge: interacts_with
AMBRA1 Gene
gene · KG edge: activates
Alzheimer Indonesia
institution · KG edge: interacts_with
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in

Knowledge Graph (12 edges)

CAT interacts_with FUNDC1
OPTN interacts_with FUNDC1
CANX interacts_with FUNDC1
LGALS3 interacts_with FUNDC1
CALCOCO2 interacts_with FUNDC1
G3BP1 interacts_with FUNDC1
PEX3 interacts_with FUNDC1
SQSTM1 interacts_with FUNDC1
BCL2 interacts_with FUNDC1
LMNA interacts_with FUNDC1

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