concept

CIRRHOSIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CIRRHOSIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

448Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CIRRHOSIS
Key Genes/Proteins	CCL2
Related Diseases	CANCER, HCV, HEPATOCELLULAR CARCINOMA, HYPERTENSION, NAFLD

Pathway Diagram

graph TD
    CIRRHOSIS["CIRRHOSIS"]
    CIRRHOSIS -->|"causes"| fibrosis["fibrosis"]
    CIRRHOSIS -->|"activates"| Pi3K["Pi3K"]
    CIRRHOSIS -->|"activates"| Akt["Akt"]
    CIRRHOSIS -->|"activates"| Mtor["Mtor"]
    CIRRHOSIS -->|"target for"| Autophagy["Autophagy"]
    CIRRHOSIS -->|"target for"| Mapk["Mapk"]
    CIRRHOSIS -->|"inhibits"| Mitophagy["Mitophagy"]
    CIRRHOSIS -->|"target for"| Immune_Response["Immune Response"]
    CIRRHOSIS -->|"activates"| Er_Stress["Er Stress"]
    gut_microbiome_modulation["gut microbiome modulation"] -->|"treats"| CIRRHOSIS
    OCLN["OCLN"] -->|"expressed in"| CIRRHOSIS
    EGF["EGF"] -->|"activates"| CIRRHOSIS
    CYP3A4["CYP3A4"] -->|"activates"| CIRRHOSIS
    PDK1["PDK1"] -->|"activates"| CIRRHOSIS
    MTOR["MTOR"] -->|"activates"| CIRRHOSIS
    EGFR["EGFR"] -->|"activates"| CIRRHOSIS
    ERCC3["ERCC3"] -->|"activates"| CIRRHOSIS
    CEBPB["CEBPB"] -->|"activates"| CIRRHOSIS
    CYP1A2["CYP1A2"] -->|"activates"| CIRRHOSIS

Outgoing (188)

Target	Relation	Type	Str
Fibrosis	associated_with	disease	1.00
Hepatitis	associated_with	disease	1.00
Fibrosis	causes	disease	0.95
Fibrosis	therapeutic_target	disease	0.85
Fibrosis	biomarker_for	disease	0.85
Carcinoma	associated_with	disease	0.85
Als	biomarker_for	disease	0.85
Oxidative Stress	therapeutic_target	pathway	0.80
Aging	associated_with	disease	0.75
Hepatitis	biomarker_for	disease	0.75
Hepatocellular Carcinoma	associated_with	disease	0.75
Fibrosis	activates	disease	0.75
Inflammation	associated_with	disease	0.75
Inflammation	therapeutic_target	disease	0.75
Hypertension	causes	disease	0.75
Als	associated_with	disease	0.75
Inflammation	causes	disease	0.75
Diabetes	associated_with	disease	0.75
Alzheimer's disease	associated_with	disease	0.70
Parkinson's disease	associated_with	disease	0.70
Lipid Metabolism	therapeutic_target	pathway	0.70
Oxidative Stress	activates	pathway	0.70
Mtor	therapeutic_target	pathway	0.70
hepatic encephalopathy	associated_with	disease	0.70
Autophagy	therapeutic_target	pathway	0.70
fibrosis	causes	process	0.70
Cancer	causes	disease	0.65
Als	therapeutic_target	disease	0.65
Infection	biomarker_for	disease	0.65
Infection	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Als	treats	disease	0.65
Cancer	associated_with	disease	0.65
Metabolic Syndrome	associated_with	disease	0.65
Type 2 Diabetes	associated_with	disease	0.65
Hepatitis	causes	disease	0.65
Fibrosis	regulates	disease	0.65
Hepatocellular Carcinoma	causes	disease	0.65
Als	causes	disease	0.65
Fibrosis	treats	disease	0.65
Inflammation	activates	disease	0.65
HEPATOCELLULAR CARCINOMA	increases_risk	disease	0.65
Carcinoma	causes	disease	0.65
Nafld	treats	disease	0.65
Hepatitis	treats	disease	0.65
Autoimmune	associated_with	disease	0.65
Unfolded Protein Response	therapeutic_target	pathway	0.60
Ampk Signaling	therapeutic_target	pathway	0.60
Mitophagy	activates	pathway	0.60
Complement	biomarker_for	pathway	0.60

Incoming (260)

Source	Relation	Type	Str
Non-Alcoholic Fatty Liver Disease	causes	disease	0.90
INFLAMMATION	associated_with	gene	0.85
CANCER	associated_with	gene	0.85
OXIDATIVE STRESS	therapeutic_target	gene	0.85
INFLAMMATION	therapeutic_target	gene	0.85
INFLAMMATION	activates	gene	0.85
INFLAMMATION	causes	gene	0.85
TNF-Α	regulates	gene	0.75
GENES	treats	gene	0.75
CYTOKINES	causes	gene	0.75
TNF	regulates	gene	0.75
MTORC1	therapeutic_target	gene	0.75
AUTOPHAGY	therapeutic_target	gene	0.75
DIABETES MELLITUS	associated_with	gene	0.75
AMPK	therapeutic_target	gene	0.75
MTOR	therapeutic_target	gene	0.75
INFLAMMATION	regulates	gene	0.75
APOPTOSIS	therapeutic_target	gene	0.75
OXIDATIVE STRESS	activates	gene	0.75
gut microbiome modulation	treats	process	0.70
gut dysbiosis	associated_with	process	0.70
CANCER	causes	gene	0.65
CYTOKINES	activates	gene	0.65
OXIDATIVE STRESS	causes	gene	0.65
TERT	associated_with	gene	0.65
MRC1	associated_with	gene	0.65
MIRNAS	treats	gene	0.65
OVERVIEW	treats	gene	0.65
DNA	treats	gene	0.65
SERPINA1	regulates	gene	0.65
INFLAMMATION	biomarker_for	gene	0.65
LDL	biomarker_for	gene	0.65
INSULIN RESISTANCE	biomarker_for	gene	0.65
CD4	activates	gene	0.65
IFN	activates	gene	0.65
INSULIN RESISTANCE	therapeutic_target	gene	0.65
CYTOKINES	therapeutic_target	gene	0.65
DIABETES MELLITUS	therapeutic_target	gene	0.65
DES	implicated_in	gene	0.65
MET	implicated_in	gene	0.65
OVERVIEW	biomarker_for	gene	0.65
PPAR-Γ	activates	gene	0.65
EXERCISE	activates	gene	0.65
PPAR	activates	gene	0.65
INSULIN RESISTANCE	associated_with	gene	0.65
ROS	activates	gene	0.65
AUTOPHAGY	activates	gene	0.65
SQSTM1	activates	gene	0.65
TRIB3	activates	gene	0.65
P62	activates	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CIRRHOSIS in their description or question text

No additional research found