protein

CAPZB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CAPZB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

46Connections

0Hypotheses

0Analyses

30Outgoing

16Incoming

0Experiments

0Debates

Summary

CAPZB is a protein involved in neurodegeneration research. Key relationships include: therapeutic target, interacts with, implicated in. Associated with Als, Ms. Connected to 11 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	CAPZB
Full Name	Capping Actin Protein of the Z-disc Beta
Chromosome	1p36.22
Function	This binding prevents the addition or loss of actin subunits at this end, functioning through several mechanisms
Primary Expression	the brain with specific patterns:
Molecular Weight	31 kDa
UniProt ID	P47756
NCBI Gene ID	832
Ensembl ID	ENSG00000015590
OMIM	601568
GeneCards	CAPZB
Human Protein Atlas	CAPZB
Associated Diseases	Als, Alzheimer
Known Drugs/Compounds	aducanumab
Interactions	CD81, GDI2, NDUFA4, NDUFS7, NEURODEGENERATIVE DISEASES, PLCB1
KG Connections	46 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CAPZB — AlphaFold P47756 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CAPZB Gene

gene · 1802 words

→

CAPZB Protein

protein · 615 words

→

Pathway Diagram

graph TD
    CAPZB["CAPZB"]
    Als{"Als"}
    CAPZB -->|"therapeutic target"| Als
    Ms{"Ms"}
    CAPZB -->|"interacts with"| Ms
    RAB5A["RAB5A"]
    CAPZB -->|"therapeutic target"| RAB5A
    HSPA1A["HSPA1A"]
    CAPZB -->|"therapeutic target"| HSPA1A
    RAB8A["RAB8A"]
    CAPZB -->|"therapeutic target"| RAB8A
    CANX["CANX"]
    CAPZB -->|"therapeutic target"| CANX
    HSPA5["HSPA5"]
    CAPZB -->|"therapeutic target"| HSPA5
    neurodegeneration["neurodegeneration"]
    CAPZB -->|"implicated in"| neurodegeneration
    RAB7A["RAB7A"]
    RAB7A -->|"therapeutic target"| CAPZB
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"interacts with"| CAPZB
    IGF2R["IGF2R"]
    IGF2R -->|"therapeutic target"| CAPZB
    style CAPZB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (30)

Target	Relation	Type	Str
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	interacts_with	disease	0.65
ALZHEIMER'S DISEASE	associated_with	gene	0.60
CD81	regulates	gene	0.60
HK1	regulates	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
AND	regulates	gene	0.60
AMYLOID	associated_with	gene	0.60
Amyloid	associated_with	pathway	0.60
Aβ	regulates	protein	0.60
Raf	regulates	protein	0.60
App	associated_with	protein	0.60
RAB5A	therapeutic_target	gene	0.60
HSPA1A	therapeutic_target	gene	0.60
RAB8A	therapeutic_target	gene	0.60
CANX	therapeutic_target	gene	0.60
HSPA5	therapeutic_target	gene	0.60
NDUFA4	regulates	gene	0.60
GDI2	regulates	gene	0.60
NDUFS7	regulates	gene	0.60
MAG	regulates	gene	0.60
PLCB1	regulates	gene	0.60
GDI2	co_expressed_with	gene	0.50
NDUFS7	interacts_with	gene	0.50
Proteins	interacts_with	protein	0.50
NDUFA4	interacts_with	gene	0.50
CD81	co_expressed_with	gene	0.50

Incoming (16)

Source	Relation	Type	Str
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
PLCB1	regulates	gene	0.60
NDUFS7	regulates	gene	0.60
aducanumab	targets	drug	0.60
MITOCHONDRIA	regulates	gene	0.60
RAB7A	therapeutic_target	gene	0.60
IGF2R	therapeutic_target	gene	0.60
CD81	regulates	gene	0.60
GDI2	regulates	gene	0.60
MAG	regulates	gene	0.60
HK1	regulates	gene	0.60
MITOCHONDRIA	interacts_with	cell_type	0.50
CD81	interacts_with	gene	0.50
GDI2	interacts_with	gene	0.50
PLCB1	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CAPZB in their description or question text

No additional research found