concept

COGNITIVE FUNCTION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about COGNITIVE FUNCTION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

83Connections

0Hypotheses

1Analyses

0Outgoing

50Incoming

0Experiments

2Debates

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💡 Concept Info

Name	COGNITIVE FUNCTION

Pathway Diagram

graph TD
    COGNITIVE_FUNCTION["COGNITIVE FUNCTION"]
    astrocytic_autophagy["astrocytic autophagy"] -.protects against.-> COGNITIVE_FUNCTION
    MAP1LC3B["MAP1LC3B"] -.protects against.-> COGNITIVE_FUNCTION
    Beta_Hydroxybutyrate["Beta-Hydroxybutyrate"] -->|"contributes to"| COGNITIVE_FUNCTION
    Insulin_Signaling["Insulin Signaling"] -->|"regulates"| COGNITIVE_FUNCTION
    BDNF["BDNF"] -->|"promotes"| COGNITIVE_FUNCTION
    ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"] -->|"regulates"| COGNITIVE_FUNCTION
    BOK["BOK"] -->|"modulates"| COGNITIVE_FUNCTION
    INS["INS"] -->|"regulates"| COGNITIVE_FUNCTION

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (83)

Source	Relation	Type	Str
Qingke Β-Glucan	associated_with	compound	0.95
Exercise Training	associated_with	process	0.94
AUTOPHAGY	modulates	process	0.92
SQSTM1	modulates	gene	0.91
Pi3K/Akt/Gsk3B Pathway	regulates	pathway	0.90
Exercise	associated_with	process	0.90
Insulin Signaling	regulates	pathway	0.90
Prosopis Cineraria	associated_with	compound	0.90
Ciliatoside A	associated_with	compound	0.90
brain-penetrant recombinant antibody	improves	compound	0.90
High-Carbohydrate Diet	associated_with	drug	0.90
Ketogenic Diet	associated_with	drug	0.90
astrocytic autophagy	protects_against	pathway	0.90
MAP1LC3B	protects_against	protein	0.90
Beta-Hydroxybutyrate	contributes_to	compound	0.90
cholinergic white matter integrity	associated_with	phenotype	0.90
BDNF	promotes	protein	0.88
aerobic exercise	associated_with	process	0.88
Β-Hydroxybutyrate	upregulates	compound	0.88
Ams-17	associated_with	compound	0.88
Inhibitory Neurons	correlates_with	cell_type	0.87
Serum Quinolinic Acid Levels	correlates_with	biomarker	0.85
Gabaergic Interneurons	mediates	cell_type	0.85
Protopanaxatriol	associated_with	compound	0.85
VEGF	involved_in	gene	0.85
Dendritic Spine Density	promotes	phenotype	0.85
Honokiol	associated_with	compound	0.85
INS	regulates	gene	0.85
NLRP3 Degradation	associated_with	process	0.85
BOK	modulates	gene	0.85
NEURON	mediates	cell_type	0.85
ALPHA-SYNUCLEIN	regulates	protein	0.85
amyloid burden	downregulates	phenotype	0.85
Ci-994	upregulates	drug	0.85
synaptic plasticity	mediates	process	0.84
p62-Dependent Autophagy	associated_with	pathway	0.82
Astrocytic Autophagy	modulates	process	0.82
SYN1	involved_in	gene	0.82
Glp-1 Receptor Agonists	protects_against	drug	0.80
Curcumin	protects_against	compound	0.80
Metabolomic Profiles	biomarker_for	biomarker	0.80
Neuroplasticity	mediates	process	0.80
CLU	protects_against	protein	0.80
BAX	downstream_of	protein	0.80
Polygala Saponins	associated_with	compound	0.80
Sleep	contributes_to	phenotype	0.80
SEMAGLUTIDE	enhances	drug	0.80
COMT val158met	associated_with	biomarker	0.80
BDNF	modulates	gene	0.80
APOE	suppresses	gene	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Investigate mechanisms of epigenetic reprogramming in aging neurons

neurodegeneration | 2026-04-10 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Investigate mechanisms of epigenetic reprogramming in aging neurons [TARGET_ART

closed · Rounds: 0 · Score: 0.50 · 2026-04-21

Investigate mechanisms of epigenetic reprogramming in aging neurons

closed · Rounds: 0 · Score: 0.56 · 2026-04-21

Related Research

Hypotheses and analyses mentioning COGNITIVE FUNCTION in their description or question text

No additional research found