protein

IGF2R

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IGF2R: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

307Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

4Experiments

1Debates

Summary

IGF2R is a protein involved in neurodegeneration research. Key relationships include: expressed in, associated with, therapeutic target. Associated with ALS, Aging, Als. Connected to 105 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	IGF2R
Protein Family	Mannose-6-phosphate receptor family
Protein Type	Receptor
Target Class	Receptor
Function	is a protein encoded by the IGF2R gene.
Mechanism of Action	Drugs targeting IGF2R typically work by blocking IGF2 binding and signaling through the IGF1R/IGF2R axis, thereby inhibiting mitogenic and anti-apoptotic effects in cancer cells. Alternatively, agents may enhance IGF2 clearance through IGF2R-mediated endocytosis to reduce circulating IGF2 levels and downstream signaling.
Primary Expression	neurons, astrocytes, and oligodendrocytes, where it participates in the regulation of IGF2 signaling and
Subcellular Localization	Cell membrane, endosomes, lysosomes
Druggability	Low (0.39)
Clinical Stage	Approved
Molecular Weight	274 kDa
Amino Acids	147 aa
Pathways	Lysosomal Enzyme Trafficking, Lysosomal function / degradation, Normal Growth and Development
UniProt ID	A0N9R6
GeneCards	IGF2R
Human Protein Atlas	IGF2R
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Known Drugs/Compounds	Linsitinib (OSI-906), Figitumumab (CP-751,871), Ganitumab (AMG 479), MK-0646 (Dalotuzumab)
Interactions	AGING, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS, AND
SciDEX Target	View Target Profile (2 clinical trials)
SciDEX Hypotheses	Lysosomal Enzyme Trafficking Correction
KG Connections	307 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: IGF2R — AlphaFold A0N9R6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

IGF2R Protein

protein · 1113 words

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Pathway Diagram

graph TD
    IGF2R["IGF2R"]
    IGF2R -->|"expressed in"| neuron["neuron"]
    IGF2R -->|"regulates"| protein_synthesis["protein synthesis"]
    IGF2R -->|"regulates"| protein_trafficking["protein trafficking"]
    IGF2R -->|"regulates"| Als["Als"]
    IGF2R -->|"expressed in"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    IGF2R -->|"expressed in"| Aging["Aging"]
    IGF2R -->|"expressed in"| Alzheimer["Alzheimer"]
    IGF2R -->|"expressed in"| Parkinson["Parkinson"]
    IGF2R -->|"expressed in"| Huntington["Huntington"]
    h_b3d6ecc2["h-b3d6ecc2"] -->|"target for"| IGF2R
    IGF2["IGF2"] -->|"interacts"| IGF2R
    JUN["JUN"] -->|"expressed in"| IGF2R
    RILP["RILP"] -->|"activates"| IGF2R
    YAP["YAP"] -->|"activates"| IGF2R
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"target for"| IGF2R
    RAB7A["RAB7A"] -->|"interacts"| IGF2R

Outgoing (202)

Target	Relation	Type	Str
lysosomal enzyme trafficking	mediates	process	0.90
IGF2 circulating levels	regulates	phenotype	0.85
IGF2 tissue levels	regulates	phenotype	0.85
cell survival	regulates	process	0.85
cell growth	regulates	process	0.85
cancer	associated_with	disease	0.85
growth-related disease	implicated_in	disease	0.80
cell migration	regulates	process	0.80
M6PR_protein	encodes	protein	0.80
protein trafficking	regulates	process	0.70
neuron	expressed_in	cell_type	0.70
protein synthesis	regulates	process	0.70
Ms	interacts_with	disease	0.65
Als	activates	disease	0.65
Als	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Huntington	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Als	regulates	disease	0.65
Alzheimer	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Als	interacts_with	disease	0.65
Ms	expressed_in	disease	0.65
ALS	associated_with	disease	0.65
Als	causes	disease	0.65
Als	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Aging	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Parkinson	expressed_in	disease	0.65
Huntington	expressed_in	disease	0.65
ALS	regulates	disease	0.65
Inflammation	associated_with	disease	0.65
ALS	activates	disease	0.65
ALS	causes	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Huntington	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Parkinson	activates	disease	0.65
Aging	activates	disease	0.65
Alzheimer	activates	disease	0.65
Infection	associated_with	disease	0.65
neurodegeneration	associated_with	disease	0.60
SMARCB1	interacts_with	gene	0.60
SORL1	interacts_with	gene	0.60
SSBP1	interacts_with	gene	0.60
STXBP3	interacts_with	gene	0.60

Incoming (105)

Source	Relation	Type	Str
h-b3d6ecc2	targets	hypothesis	0.90
Rab7	regulates	protein	0.85
IGF2	interacts_with	protein	0.70
PD-L1	therapeutic_target	gene	0.60
ATP6V1G1	causes	gene	0.60
ENDOSOMES	causes	gene	0.60
YAP	causes	gene	0.60
RILP	causes	gene	0.60
CANCER	regulates	entity	0.60
CANCER	interacts_with	entity	0.60
ALZHEIMER	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
ENDOSOMES	interacts_with	gene	0.60
LYSOSOME	activates	gene	0.60
INFLAMMATION	associated_with	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
AND	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
ALS	activates	gene	0.60
AGING	activates	gene	0.60
PARKINSON	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
MTOR	associated_with	gene	0.60
APOE	associated_with	gene	0.60
RNF14	associated_with	gene	0.60
STXBP3	associated_with	gene	0.60
IGF2	expressed_in	gene	0.60
JUN	expressed_in	gene	0.60
RAB7	associated_with	gene	0.60
RILP	activates	gene	0.60
RAB7A	associated_with	gene	0.60
APOE	causes	gene	0.60
APP	causes	gene	0.60
COPA	interacts_with	gene	0.60
ATP6V1G1	activates	gene	0.60
AND	causes	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
YAP	activates	gene	0.60
AND	expressed_in	gene	0.60
COPA	associated_with	gene	0.60
IGF2	treats	entity	0.60
APP	interacts_with	gene	0.60
IDS	interacts_with	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
RAB7A	causes	gene	0.60
HSP90AA1	associated_with	gene	0.60
IGF2	regulates	entity	0.60
RNA	activates	gene	0.60
RAB7A	therapeutic_target	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Lysosomal Enzyme Trafficking Correction	0.706	neurodegeneration	Autophagy-lysosome pathway convergence a

Mentioning Analyses (1)

Scientific analyses that reference this entity

Autophagy-lysosome pathway convergence across neurodegenerative diseases

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.882

Experiments (4)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Chaperone-Mediated Autophagy Dysfunction in PD - Experiment Design	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Presymptomatic GRN Carrier Intervention Timing — Biomarker-Guided Ther	clinical	Neurodegeneration	0.400	0.50	human	proposed	$5,460,000
Proteasome-Ubiquitin System Dysfunction Validation in Parkinson's Dise	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
TMEM106B Haplotype as Genetic Modifier in FTD — Mechanism and Therapeu	validation	Neurodegeneration	0.400	0.50	human	proposed	$2,730,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Designed endocytosis-inducing proteins degrade targets and amplify signals. [PMID:39322662]	Huang B, Abedi M, Ahn G, Coventry B, Sap	Nature	2025	1
Collapse of late endosomal pH elicits a rapid Rab7 response via the V-ATPase and [PMID:38578235]	Mulligan RJ, Magaj MM, Digilio L, Redema	J Cell Sci	2024	1
IGF2 in memory, neurodevelopmental disorders, and neurodegenerative diseases. [PMID:37031050]	Alberini CM	Trends Neurosci	2023	1
Interactions of IGF-II with the IGF2R/cation-independent mannose-6-phosphate rec [PMID:19251056]	Brown J, Jones EY, Forbes BE	Vitam Horm	2009	1
Soluble ST2 drives fulminant myocarditis progression via the IGF2R-YY1 mitochond [PMID:41684269]	Zhuang Y, Zhang Z, Li H, Abuduwufuer K,	European heart journal	2026	0
Distribution and Levels of Insulin-like Growth Factor 2 Receptor Across Mouse Br [PMID:41725679]	Gaunt JR, Manoj G, Alberini CM	Receptors (Basel, Switzerland)	2026	0
Distinctive respiratory toxicity induced by hypoxanthine metabolic disorder from [PMID:41921402]	Xu X, He M, Lan M, Qiu L, Wang J, Zhong	Environment international	2026	0
Itaconic Acid Activates Lysosomal Biogenesis and Autophagy Flux and Mitigates Hi [PMID:41596065]	Li X, Wang S, Zhang M, Li M, Chen C	Antioxidants (Basel, Switzerla	2025	0
The Pathophysiology of Keratoconus. [PMID:38830186]	["Vought R", "Greenstein S", "Gelles J",	Cornea	2025	0
The intracellular localization and the ionic permeation of TRPV6 triggers chroni [PMID:41437274]	Fecher-Trost C, Gehl AL, Trunk A, Hellmi	Cell communication and signali	2025	0
CREG1 promotes lysosomal biogenesis and function. [PMID:33966596]	Liu J, Qi Y, Chao J, Sathuvalli P, Y Lee	Autophagy	2021	0
Live imaging of intra-lysosome pH in cell lines and primary neuronal culture usi [PMID:32515674]	Ponsford AH, Ryan TA, Raimondi A, Cocucc	Autophagy	2021	0
Identification and quantitation of the actual active components in bamboo juice [PMID:33184510]	["Gao Q", "Wang D", "Shao S", "Xue Y", "	Scientific reports	2020	0
TOM1 Regulates Neuronal Accumulation of Amyloid-β Oligomers by FcγRIIb2 Variant [PMID:30185465]	["Gwon Y", "Kam T", "Kim S", "Song S", "	The Journal of neuroscience :	2018	0
Revisiting LAMP1 as a marker for degradative autophagy-lysosomal organelles in t [PMID:29940787]	Cheng XT, Xie YX, Zhou B, Huang N, Farfe	Autophagy	2018	0
A novel DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) i [PMID:25556849]	["Coutadeur S", "Benyamine H", "Delalond	Journal of neurochemistry	2015	0
Hierarchical phosphorylation within the ankyrin repeat domain defines a phosphor [PMID:21685388]	["Ranganathan P", "Vasquez-Del Carpio R"	The Journal of biological chem	2011	0
A novel rat model with obesity-associated retinal degeneration. [PMID:19369235]	["Reddy G", "Vasireddy V", "Mandal M", "	Investigative ophthalmology &	2009	0
Protective immune responses against West Nile virus are primed by distinct compl [PMID:16651386]	["Mehlhop E", "Diamond M"]	The Journal of experimental me	2006	0
Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, caus [PMID:15654338]	["Metherell L", "Chapple J", "Cooray S",	Nature genetics	2005	0

Debates (1)

Multi-agent debates referencing this entity

Multiple NDDs converge on autophagy-lysosome dysfunction. Are there universal th

closed · Rounds: 4 · Score: 0.90 · 2026-04-06

Related Research

Hypotheses and analyses mentioning IGF2R in their description or question text

No additional research found