gene

GLIOBLASTOMA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GLIOBLASTOMA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2904Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

GLIOBLASTOMA is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, associated with. Associated with ALS, ALZHEIMER'S DISEASE, Aging. Connected to 605 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	GLIOBLASTOMA
Associated Diseases	Aging, Als, Alzheimer, Breast Cancer, Cancer
Known Drugs/Compounds	TEMOZOLOMIDE
Interactions	Actin, ADSL, AGING, AKT, ALDH1A3, ALS
KG Connections	1389 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    GLIOBLASTOMA["GLIOBLASTOMA"] -->|"associated"| MITOCHONDRIA["MITOCHONDRIA"]
    GLIOBLASTOMA["GLIOBLASTOMA"] -->|"associated"| Tumor["Tumor"]
    GLIOBLASTOMA["GLIOBLASTOMA"] -->|"associated"| Glioblastoma["Glioblastoma"]
    GLIOBLASTOMA["GLIOBLASTOMA"] -->|"activates"| Cancer["Cancer"]
    GLIOBLASTOMA["GLIOBLASTOMA"] -->|"expressed in"| Parkinson["Parkinson"]
    GLIOBLASTOMA["GLIOBLASTOMA"] -->|"expressed in"| Glioblastoma_1["Glioblastoma"]
    PI3K_AKT_MTOR_PATHWAY["PI3K_AKT_MTOR_PATHWAY"] -->|"activates"| GLIOBLASTOMA["GLIOBLASTOMA"]
    MTOR["MTOR"] -->|"activates"| GLIOBLASTOMA["GLIOBLASTOMA"]
    AUTOPHAGY["AUTOPHAGY"] -->|"co discussed"| GLIOBLASTOMA["GLIOBLASTOMA"]
    ALZHEIMER["ALZHEIMER"] -->|"co discussed"| GLIOBLASTOMA["GLIOBLASTOMA"]
    style GLIOBLASTOMA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1072)

Target	Relation	Type	Str
Glioblastoma	associated_with	disease	1.00
Glioma	associated_with	disease	1.00
Tumor	therapeutic_target	disease	1.00
Glioma	activates	disease	1.00
Glioblastoma	inhibits	disease	1.00
Cancer	therapeutic_target	disease	1.00
Neurodegeneration	activates	disease	1.00
Tumor	inhibits	disease	1.00
Glioblastoma	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
Tumor	associated_with	disease	1.00
Cancer	activates	disease	1.00
Glioblastoma	regulates	disease	1.00
Tumor	activates	disease	1.00
Als	activates	disease	1.00
Glioblastoma	activates	disease	1.00
immunosuppressive microenvironment	associated_with	phenotype	0.95
blood-brain barrier	involves	pathway	0.90
Cranial Bone Marrow	associated_with	cell_type	0.90
neural stem cells	affects	cell_type	0.90
lipid metabolism	activates	process	0.90
oxidative stress response	involves	pathway	0.90
neurons	affects	cell_type	0.90
blood-brain barrier	affects	brain_region	0.90
PI3K-AKT-mTOR signaling	involves	pathway	0.90
macrophages	affects	cell_type	0.90
Brain Tumor	associated_with	disease	0.90
unfolded protein response	involves	pathway	0.90
Mtor	activates	pathway	0.90
Autophagy	activates	pathway	0.90
MTOR	activates	gene	0.90
Mtor	activates	pathway	0.90
Tumor Microenvironment	therapeutic_target	pathway	0.90
Autophagy	activates	pathway	0.90
Glioma	therapeutic_target	disease	0.85
Als	associated_with	disease	0.85
Als	regulates	disease	0.85
Glioma	regulates	disease	0.85
Cancer	associated_with	disease	0.85
Glioblastoma	treats	disease	0.85
Tumor	treats	disease	0.85
Therapy Resistance	associated_with	phenotype	0.85
Circadian Rhythms	interacts_with	process	0.85
Cancer	inhibits	disease	0.85
astrocytes	affects	cell_type	0.80
ubiquitin-proteasome	involves	pathway	0.80
Immunosuppression	associated_with	phenotype	0.80
Metabolic Resistance	causes	phenotype	0.80
lipid metabolism	involves	pathway	0.80
Immune System	associated_with	process	0.80

Incoming (1832)

Source	Relation	Type	Str
GBM	associated_with	gene	1.00
GLIOBLASTOMA	associated_with	gene	1.00
EGFR	activates	gene	1.00
Als	activates	disease	1.00
GBM	associated_with	gene	1.00
CANCER	therapeutic_target	gene	1.00
CANCER	activates	gene	1.00
Als	therapeutic_target	disease	1.00
Cancer	activates	disease	1.00
Tumor	therapeutic_target	disease	1.00
GLIOBLASTOMA	regulates	gene	1.00
Cancer	therapeutic_target	disease	1.00
Tumor	associated_with	disease	1.00
CANCER	activates	gene	1.00
GLIOBLASTOMA	activates	gene	1.00
NEURODEGENERATION	activates	gene	1.00
GBM	therapeutic_target	gene	1.00
GLIOBLASTOMA	inhibits	gene	1.00
GLIOBLASTOMA	therapeutic_target	gene	1.00
CANCER	therapeutic_target	gene	1.00
Tumor	activates	disease	1.00
GBM	therapeutic_target	gene	1.00
EGFR	activates	gene	1.00
IDH1	associated_with	entity	0.98
Glioma	activates	disease	0.95
Pi3K/Akt/Mtor	involved_in	pathway	0.95
GBM	activates	gene	0.95
Glioma	associated_with	disease	0.95
Neurodegeneration	activates	disease	0.95
Glucocorticoids	modulates	compound	0.95
MTOR	activates	gene	0.95
AUTOPHAGY	activates	gene	0.95
Glioblastoma Stem Cells	involved_in	cell_type	0.95
GR	regulates	receptor	0.95
Lipid Metabolism	promotes	pathway	0.95
PI3K/Akt/mTOR	upregulates	pathway	0.95
AKT	therapeutic_target	gene	0.95
PI3K	therapeutic_target	gene	0.95
Compound 1F	suppresses	compound	0.95
PI3K	activates	gene	0.95
IDH2	associated_with	gene	0.92
PTEN Deficiency	associated_with	biomarker	0.90
CAR T cells	treats	cell_type	0.90
Cranial Bone Marrow	associated_with	brain_region	0.90
Axonal Injury	associated_with	process	0.90
GBM	treats	gene	0.90
Lactate	contributes_to	compound	0.90
Mt-125	treats	drug	0.90
GBM	regulates	gene	0.90
Lipid Metabolism	contributes_to	pathway	0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GLIOBLASTOMA in their description or question text

No additional research found