concept

TRIM21

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRIM21: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

316Connections

5Hypotheses

3Analyses

50Outgoing

50Incoming

1Experiments

3Debates

Summary

TRIM21 is a concept in neurodegeneration research. Key relationships include: activates, interacts with, regulates. Associated with AD, ALI, AMI. Connected to 176 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	TRIM21
Key Genes/Proteins	ACE, ACTB, Actin, AKT, ALZHEIMER, amyotrophic lateral sclerosis
Related Diseases	AD, Aging, ALI, Als, ALS
Related Pathways	Akt
Linked Hypotheses	5 hypotheses

Pathway Diagram

graph TD
    TRIM21["TRIM21"]
    TRIM21 -->|"interacts"| Carcinoma["Carcinoma"]
    TRIM21 -->|"ubiquitinates"| SQSTM1["SQSTM1"]
    TRIM21 -->|"interacts"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    TRIM21 -->|"interacts"| Dementia["Dementia"]
    TRIM21 -->|"interacts"| OPTN["OPTN"]
    TRIM21 -->|"activates"| NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    TRIM21 -->|"interacts"| ACTB["ACTB"]
    TRIM21 -->|"interacts"| ALS["ALS"]
    TRIM21 -->|"interacts"| CALCOCO2["CALCOCO2"]
    TRIM21 -->|"interacts"| NBR1["NBR1"]
    SQSTM1 -->|"binds"| TRIM21
    C9ORF72["C9ORF72"] -->|"interacts"| TRIM21
    LC3["LC3"] -->|"interacts"| TRIM21
    P62["P62"] -->|"interacts"| TRIM21
    FUS["FUS"] -->|"interacts"| TRIM21
    UBIQUITIN["UBIQUITIN"] -->|"regulates"| TRIM21
    SMCR8["SMCR8"] -->|"interacts"| TRIM21
    NDP52["NDP52"] -->|"interacts"| TRIM21
    CALCOCO2 -->|"interacts"| TRIM21

Outgoing (199)

Target	Relation	Type	Str
Cancer	activates	disease	1.00
TAB1	interacts_with	protein	0.95
stress granules	regulates	process	0.95
Stress Granule Homeostasis	regulates	process	0.95
G3BP1	phosphorylates	protein	0.95
Stress Granule Homeostasis	modulates	process	0.95
STRESS GRANULE HOMEOSTASIS	regulates	entity	0.95
stress granule homeostasis	regulates	process	0.92
Nuclear Pore Proteins	degrades	protein	0.92
stress granules	expressed_in	cellular_structure	0.90
ubiquitin	interacts_with	protein	0.90
SG elimination	modulates	process	0.90
SG formation	modulates	process	0.90
NUP98	degrades	protein	0.90
SQSTM1	inhibits	protein	0.90
Multimeric Proteins	degrades	protein	0.90
SG FORMATION	regulates	entity	0.90
G3BP1	associated_with	protein	0.90
SG FORMATION	inhibits	entity	0.90
IgG	binds	protein	0.90
CANCER	activates	gene	0.90
ubiquitin ligase pathway	participates_in	pathway	0.88
Substrate-Induced Clustering	associated_with	process	0.88
Stress Granule Formation	inhibits	phenotype	0.85
Nucleocytoplasmic Trafficking	regulates	process	0.85
oxidative stress	promotes	process	0.85
Tumor	activates	disease	0.85
Biomolecular Condensates	targets	process	0.85
Stress Granules	inhibits_formation	cellular_structure	0.80
Carcinoma	interacts_with	disease	0.80
Oxidative Stress	associated_with	process	0.80
Stress Granules	regulates	biological_process	0.80
Oxidative Stress	activates	pathway	0.80
AKT	activates	gene	0.80
Als	activates	disease	0.75
Neurodegenerative Diseases	therapeutic_target	disease	0.75
Carcinoma	activates	disease	0.75
Hepatocellular Carcinoma	activates	disease	0.75
UBIQUITIN	regulates	gene	0.70
CALCOCO2	interacts_with	gene	0.70
SQSTM1	ubiquitinates	gene	0.70
ubiquitin-proteasome	participates_in	pathway	0.70
Als	causes	disease	0.65
Als	regulates	disease	0.65
Breast Cancer	activates	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Cardiovascular	activates	disease	0.65
Heart Failure	protects_against	disease	0.65
Dementia	interacts_with	disease	0.65
Tumor	expressed_in	disease	0.65

Incoming (117)

Source	Relation	Type	Str
Acepromazine	activates	drug	0.95
(S)-Ace-Oh	activates	compound	0.90
OXIDATIVE STRESS	activates	gene	0.80
PI3K	activates	gene	0.70
NDP52	interacts_with	gene	0.70
KEAP1	activates	gene	0.70
P62	activates	gene	0.70
SQSTM1	binds	gene	0.70
STING1	interacts_with	gene	0.60
MYC	regulates	gene	0.60
AND	activates	gene	0.60
C-MYC	regulates	gene	0.60
WNT	interacts_with	gene	0.60
UBIQUITIN	expressed_in	gene	0.60
NLRP3	activates	gene	0.60
PYROPTOSIS	activates	gene	0.60
CYTOKINES	activates	gene	0.60
HDAC6	activates	gene	0.60
SQSTM1	regulates	gene	0.60
NFE2L2	activates	gene	0.60
UBIQUITIN	associated_with	gene	0.60
C9ORF72	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
FUS	interacts_with	gene	0.60
UBIQUITIN	regulates	gene	0.60
SQSTM1	interacts_with	gene	0.60
SMCR8	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
OPTINEURIN	interacts_with	gene	0.60
AUTOPHAGY	regulates	gene	0.60
G3BP1	interacts_with	gene	0.60
ALS	interacts_with	gene	0.60
MAP1LC3	interacts_with	gene	0.60
ACTB	interacts_with	gene	0.60
DEMENTIA	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
TOLLIP	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	gene	0.60
GFP	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
FUT8	activates	gene	0.60
PI3K	regulates	gene	0.60
UBIQUITIN	activates	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
STAT3	activates	gene	0.60
NF-ΚB	activates	gene	0.60

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TRIM21 as a 'Phase Separation Thermostat' via Catalytic Reve	0.700	neurodegeneration	How does TRIM21-mediated K63 ubiquitinat
ALS-Associated G3BP1/2 Mutations Disrupt TRIM21 Binding Inte	0.585	neurodegeneration	How do pathological stress granules in n
TRIM21-Mediated Ubiquitination Creates Peripheral Epitope Gr	0.548	neurodegeneration	What determines the spatial organization
Hyperphosphorylated TDP-43 Traps TRIM21 Into Inactive Comple	0.487	neurodegeneration	How do pathological stress granules in n
Casein Kinase 2 (CK2)-Mediated Hyperphosphorylation of G3BP1	0.440	neurodegeneration	How do pathological stress granules in n

Mentioning Analyses (3)

Scientific analyses that reference this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
TRIM21 E3 ubiquitin ligase screen for stress granule regulation	exploratory	neurodegenerative diseases	0.900	0.00	cultured cells	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning TRIM21 in their description or question text

No additional research found

TRIM21

Understanding Entity Pages

Summary

Pathway Diagram

Outgoing (199)

Incoming (117)

Targeting Hypotheses (5)

Mentioning Analyses (3)

What determines the spatial organization of autophagy receptors at stress granul

How does TRIM21-mediated K63 ubiquitination of G3BP1 mechanistically inhibit liq

How do pathological stress granules in neurodegeneration escape TRIM21/autophagy

Experiments (1)

Related Papers (0)

Debates (3)

The study shows TRIM21 and autophagy receptors can eliminate both physiological

The study shows that G3BP1 ubiquitination inhibits LLPS in vitro, but the molecu

SQSTM1 and CALCOCO2 specifically localize to SG periphery rather than throughout

Related Research