gene

VPS13D

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VPS13D: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

18Connections

0Hypotheses

0Analyses

16Outgoing

2Incoming

0Experiments

0Debates

Summary

VPS13D is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, implicated in. Associated with Ms, Parkinson. Connected to 13 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	VPS13D
Chromosome	1p36.22
Protein Type	Gene
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	500 kDa
Amino Acids	377 aa
Exons	76
GeneCards	VPS13D
Human Protein Atlas	VPS13D
N-terminal Domain	Mediates protein-protein interactions and membrane association
Chorein Domain	The central domain responsible for lipid transfer activity between membranes
C-terminal Regions	Involved in organelle targeting and regulation
Spinocerebellar Ataxia (SCA)	Characterized by progressive cerebellar ataxia, dysarthria, and oculomotor abnormalities
Hereditary Spastic Paraplegia (HSP)	Characterized by progressive lower limb spasticity and weakness
Alzheimer's Disease	Altered VPS13D expression reported in AD brains; may affect APP processing and Aβ metabolism through membrane trafficking pathways
Associated Diseases	Ms, Parkinson
Interactions	PARKIN, STING, UBIQUITIN
KG Connections	18 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    VPS13D["VPS13D"]
    Parkinson{"Parkinson"}
    VPS13D -->|"associated with"| Parkinson
    Ms{"Ms"}
    VPS13D -->|"associated with"| Ms
    GBA["GBA"]
    VPS13D -->|"associated with"| GBA
    VPS11["VPS11"]
    VPS13D -->|"associated with"| VPS11
    GENES["GENES"]
    VPS13D -->|"associated with"| GENES
    PIK3C3["PIK3C3"]
    VPS13D -->|"associated with"| PIK3C3
    LRRK2["LRRK2"]
    VPS13D -->|"associated with"| LRRK2
    Mitophagy(["Mitophagy"])
    VPS13D -->|"associated with"| Mitophagy
    Autophagy(["Autophagy"])
    VPS13D -->|"associated with"| Autophagy
    PARKIN["PARKIN"]
    VPS13D -->|"interacts with"| PARKIN
    UBIQUITIN["UBIQUITIN"]
    VPS13D -->|"interacts with"| UBIQUITIN
    neurodegeneration["neurodegeneration"]
    VPS13D -->|"implicated in"| neurodegeneration
    VPS35["VPS35"]
    VPS35 -->|"associated with"| VPS13D
    style VPS13D fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (16)

Target	Relation	Type	Str
Parkinson	associated_with	disease	0.65
Ms	associated_with	disease	0.65
PIK3C3	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
GENES	associated_with	gene	0.60
Mitophagy	associated_with	pathway	0.60
GBA	associated_with	gene	0.60
Autophagy	associated_with	pathway	0.60
VPS11	associated_with	gene	0.60
neuroinflammation	activates	disease	0.60
autism spectrum disorder	activates	disease	0.60
pyroptosis	participates_in	pathway	0.60
microglia	expressed_in	cell_type	0.60
neurons	expressed_in	cell_type	0.60
PARKIN	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60

Incoming (2)

Source	Relation	Type	Str
VPS35	associated_with	gene	0.60
STING	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning VPS13D in their description or question text

No additional research found