concept

AMI

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AMI: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

114Connections

29Hypotheses

0Analyses

0Outgoing

50Incoming

10Experiments

0Debates

Summary

AMI is a concept in neurodegeneration research. Key relationships include: implicated in, associated with. Connected to 113 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	AMI
Key Genes/Proteins	A2M, ABCA1, ABCG1, ACTB, AKT, ALS

Pathway Diagram

graph TD
    AMI["AMI"]
    MAP1B["MAP1B"] -->|"implicated in"| AMI
    MAP2["MAP2"] -->|"implicated in"| AMI
    MAP6["MAP6"] -->|"implicated in"| AMI
    RAB7A["RAB7A"] -->|"implicated in"| AMI
    LRP2["LRP2"] -->|"implicated in"| AMI
    ACTB["ACTB"] -->|"implicated in"| AMI
    CTSD["CTSD"] -->|"implicated in"| AMI
    ATG["ATG"] -->|"implicated in"| AMI
    EGFR["EGFR"] -->|"implicated in"| AMI
    SREBF1["SREBF1"] -->|"implicated in"| AMI

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (114)

Source	Relation	Type	Str
MMP9	associated_with	protein	0.72
41484454	has neuroprotective effects through	paper	0.60
IDH1	implicated_in	gene	0.50
MCU	implicated_in	gene	0.50
LETM1	implicated_in	gene	0.50
P2RY12	implicated_in	gene	0.50
LC3	implicated_in	gene	0.50
APOA1	implicated_in	gene	0.50
PI3K	implicated_in	gene	0.50
MAP1LC3	implicated_in	gene	0.50
ABCG1	implicated_in	gene	0.50
LOX	implicated_in	gene	0.50
AMPK	implicated_in	gene	0.50
AKT	implicated_in	gene	0.50
ABCA1	implicated_in	gene	0.50
ULK1	implicated_in	gene	0.50
LDL	implicated_in	gene	0.50
ATG5	implicated_in	gene	0.50
IBA1	implicated_in	gene	0.50
REL	implicated_in	gene	0.50
CERS2	implicated_in	gene	0.50
HSPG2	implicated_in	gene	0.50
DAPK1	implicated_in	gene	0.50
PARP1	implicated_in	gene	0.50
A2M	implicated_in	gene	0.50
DHCR24	implicated_in	gene	0.50
HMGCR	implicated_in	gene	0.50
IL6	implicated_in	gene	0.50
PSEN1	implicated_in	gene	0.50
APH1B	implicated_in	gene	0.50
APP	implicated_in	gene	0.50
PEN2	implicated_in	gene	0.50
MAPT	implicated_in	gene	0.50
FAS	implicated_in	gene	0.50
IL1B	implicated_in	gene	0.50
TNF	implicated_in	gene	0.50
PSEN2	implicated_in	gene	0.50
EIF2AK2	implicated_in	gene	0.50
LMNA	implicated_in	gene	0.50
NCSTN	implicated_in	gene	0.50
RASA1	implicated_in	gene	0.50
HSPA1A	implicated_in	gene	0.50
ERK1	implicated_in	gene	0.50
ERK	implicated_in	gene	0.50
JNK	implicated_in	gene	0.50
PRMT1	implicated_in	gene	0.50
PHGDH	implicated_in	gene	0.50
FASN	implicated_in	gene	0.50
G3BP1	implicated_in	gene	0.50
ALS	implicated_in	gene	0.50

Targeting Hypotheses (29)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Palmitoylethanolamide-Based Endocannabinoid Therapy	0.919	-	Blood-brain barrier tight junction disru
Sequential Iron Chelation (Deferoxamine) and GPX4 Restoratio	0.838	neurodegeneration	View
CSF sTREM2 as Pharmacodynamic Biomarker for Therapeutic Wind	0.801	neuroimmunology	TREM2 in Alzheimer's Disease: Mechanisms
NMN Supplementation Restores SIRT1/p66Shc/FOXO3 Epigenetic A	0.790	neurodegeneration	epigenetic reprogramming aging neurons
Tau/MAP6 ratio as a master switch for microtubule dynamics p	0.750	neurodegeneration	View

Dopaminergic Ventral Tegmental-Hippocampal Circuit Protectio	0.740	neuroscience	Circuit-level neural dynamics in neurode
SMPD1 (Acid Sphingomyelinase) Inhibition for Ceramide Reduct	0.732	neurodegeneration	How do sphingomyelin/ceramide ratios spe
TDP-43 condensation thermodynamics as a therapeutic target a	0.710	neuroscience	How can subcellular compartmentalization
CD8+ T-Cell Perforin Pathway as Driver of Neuronal Pyramid L	0.710	Alzheimer's disease, Parkinson's disease	-
Ataxin-2 Polyglutamine Expansions Hijack G3BP1 to Form Toxic	0.700	neurodegeneration	How do disease-associated mutations in G
Lysosomal Positioning Dynamics Modulation	0.686	neurodegeneration	Autophagy-lysosome pathway convergence a
Bacterial Tyramine–Induced DOPAL Accumulation in Enteric Neu	0.680	neurodegeneration	What are the mechanisms by which gut mic
Dynamic Lactate-Pyruvate Ratio as Therapeutic Stratification	0.677	translational neuroscience	Which metabolic biomarkers can distingui
Lipid Droplet Dynamics as Phenotype Switches	0.666	neurodegeneration	Astrocyte reactivity subtypes in neurode
Lactate/Pyruvate Ratio Dynamics in CSF as a Neuroinflammatio	0.665	translational neuroscience	Which metabolic biomarkers can distingui
Mitochondrial Biogenesis Rate as a Dynamic Biomarker of Neur	0.652	translational neuroscience	Which metabolic biomarkers can distingui
Transglutaminase-2 Cross-Linking Inhibition Strategy	0.639	neurodegeneration	Protein aggregation cross-seeding across
BH4 Cofactor Restoration as Primary Driver of >500-Fold Dopa	0.618	neurodegeneration	What molecular mechanisms underlie Atrem
Correcting Gut Microbial Dopamine Imbalance to Support Syste	0.606	neurodegeneration	What are the mechanisms by which gut mic
Glycosaminoglycan Template Disruption Approach	0.597	neurodegeneration	Protein aggregation cross-seeding across
Dynamic Microglial Phenotype Switching Biomarker Panel for N	0.577	neurodegeneration	What amyloid threshold level is required
HCN1-Selective Blockade Normalizes Thalamic Rebound Bursting	0.526	synaptic biology	How do P/Q channel deficits paradoxicall
Lamin B1 Degradation as Irreversibility Gate	0.523	molecular biology	What is the optimal therapeutic window t
Loss of Nuclear Lamin B1 Distinguishes Senescent Microglia f	0.520	neurodegeneration	How can senescent microglia be molecular
Lamin B1 Restoration Prevents Age-Related Nuclear Lamina Com	0.510	neurodegeneration	Investigate mechanisms of epigenetic rep
Small-Molecule Modulation of G3BP1 Condensate Dynamics via P	0.400	neurodegeneration	How do disease-associated mutations in G
Branched-Chain Amino Acid Transamination Inhibition to Modul	0.400	metabolomics	Metabolomic signatures of neurodegenerat
Exposure profile may matter more than nominal daily dose, bu	0.390	neurodegeneration	-
Bacterial Enzyme-Mediated Dopamine Precursor Synthesis	0.384	neurodegeneration	What are the mechanisms by which gut mic

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (10)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
Plasma ATN biomarkers across AD continuum in Chilean cohort	clinical	Alzheimer's disease	0.950	Chilean older adults (n=318) w	proposed	N/A
Autophagy receptor identification for stress granule elimination	exploratory	neurodegenerative diseases	0.900	cultured cells under arsenite	proposed	N/A
Epigenetic clocks association with brain aging patterns in older women	exploratory	cognitive impairment and demen	0.900	human patients	proposed	N/A
Tau depletion effects on neuronal development in primary cultures	exploratory		0.900	primary rodent neuronal cultur	proposed	N/A
Differential GWAS of schizophrenia vs PTSD	exploratory	schizophrenia, post-traumatic	0.900	human patients - European ance	proposed	N/A
Tau depletion effects on neuronal development in primary cultures	exploratory		0.900	primary rodent neuronal cultur	proposed	N/A
Creation and validation of 3xAD-ChAT-Cre mouse model	validation	Alzheimer's disease	0.900	3xAD-ChAT-Cre transgenic mice	proposed	N/A
GTEx brain tissue expression analysis of MAPT/CRHR1 locus	exploratory	schizophrenia, post-traumatic	0.850	human brain tissue samples fro	proposed	N/A
Microtubule domain analysis in adult axons	exploratory		0.800	adult rodent axons	proposed	N/A
Tau depletion effects on microtubule domains in adult axons	exploratory		0.800	adult rodent neurons	proposed	N/A

Related Papers (18)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Pathogenic Variants and Olipudase Alfa Treatment of Patients With Acid Sphingomy [PMID:41692468]	["Hsu-Heng Lin", "Hui-An Chen", "Shyh-Je	Molecular genetics & genom	2026
Multi-omics analysis identifies SMPD1 as a key contributor in sphingolipid pathw [PMID:41428198]	["Aron Park", "Baeki E Kang", "Eun-Ju Ji	Genes & genomics	2026
Mammalian lipophagy: process and function. [PMID:41681129]	Zhao R, Dai E, Kang R, Liu J, Klionsky D	Autophagy	2026
A multi-dimensional bioinformatic dissection of the molecular mechanisms in high [PMID:41191606]	Yu X MD, Lei J MSc, Du X MSc, He Y MSc,	Int J Surg	2026
Plasma metabolites may inhibit childhood obesity by regulating ferroptosis throu [PMID:41249848]	Wang JG, Pan XH, Li Y	Int J Obes (Lond)	2026
Multi-omics analysis identifies SMPD1 as a key contributor in sphingolipid pathw [PMID:41428198]	Park A, Kang BE, Jin EJ, Kim HJ, Lee CW	Genes Genomics	2026
AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition [PMID:41524160]	Jia J, Gan Y, Li J, Li L, Meng H et al.	Adv Sci (Weinh)	2026
Pathogenic Variants and Olipudase Alfa Treatment of Patients With Acid Sphingomy [PMID:41692468]	Lin HH, Chen HA, Lin SJ, Hsu RH, Lee NC	Mol Genet Genomic Med	2026
AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition [PMID:41524160]	Jia J, Gan Y, Li J, Li L, Meng H, Sun M,	Advanced science (Weinheim, Ba	2026
A multi-dimensional bioinformatic dissection of the molecular mechanisms in high [PMID:41191606]	Yu X, Lei J, Du X, He Y, Peng W, Yang R,	International journal of surge	2026
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Current View on PPAR-α and Its Relation to Neurosteroids in Alzheimer's Di [PMID:39000217]	Unknown	International journal of molec	2024
Neurodegeneration and demyelination in multiple sclerosis. [PMID:38889714]	Garton T, Gadani SP, Gill AJ, Calabresi	Neuron	2024
STING orchestrates the neuronal inflammatory stress response in multiple scleros [PMID:38878778]	Woo MS, Mayer C, Binkle-Ladisch L, Sonne	Cell	2024
Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration. [PMID:36917977]	Neel DV, Basu H, Gunner G, Bergstresser	Neuron	2023
Pyrethroid exposure and neurotoxicity: a mechanistic approach. [PMID:31246571]	Unknown	Arhiv za higijenu rada i toksi	2020
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Multiple Sclerosis Pathology. [PMID:29358320]	Lassmann H	Cold Spring Harbor perspective	2018

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning AMI in their description or question text

Dopaminergic Ventral Tegmental-Hippocampal Circuit Protection

Score: 0.740 · neuroscience · 2026-04-07

## Mechanistic Overview Dopaminergic Ventral Tegmental-Hippocampal Circuit Protection starts from the claim that modulat

SMPD1 (Acid Sphingomyelinase) Inhibition for Ceramide Reduction and BACE1 Regula

Score: 0.732 · neurodegeneration · 2026-04-16

**Molecular Mechanism and Rationale** The molecular foundation for SMPD1 inhibition in Alzheimer's disease centers on t

TDP-43 condensation thermodynamics as a therapeutic target and biomarker for nuc

Score: 0.710 · neuroscience · 2026-04-26

FRAP-based measurement of TDP-43 liquid-liquid phase separation state provides a continuous biomarker of nuclear-cytopla

Ataxin-2 Polyglutamine Expansions Hijack G3BP1 to Form Toxic, Irreversible Stres

Score: 0.700 · neurodegeneration · 2026-04-22

## Mechanistic Overview Ataxin-2 Polyglutamine Expansions Hijack G3BP1 to Form Toxic, Irreversible Stress Granule Comple

Lysosomal Positioning Dynamics Modulation

Score: 0.686 · neurodegeneration · 2026-04-02

## Mechanistic Overview Lysosomal Positioning Dynamics Modulation starts from the claim that modulating LAMP1 within the

Bacterial Tyramine–Induced DOPAL Accumulation in Enteric Neurons

Score: 0.680 · neurodegeneration · 2026-04-22

## **Molecular Mechanism and Rationale** The proposed mechanism centers on a complex interplay between gut microbiota,

Dynamic Lactate-Pyruvate Ratio as Therapeutic Stratification Biomarker

Score: 0.677 · translational neuroscience · 2026-04-16

## Mechanistic Overview Dynamic Lactate-Pyruvate Ratio as Therapeutic Stratification Biomarker starts from the claim tha

Lipid Droplet Dynamics as Phenotype Switches

Score: 0.666 · neurodegeneration · 2026-04-02

## Mechanistic Overview Lipid Droplet Dynamics as Phenotype Switches starts from the claim that modulating DGAT1 and SOA

Lactate/Pyruvate Ratio Dynamics in CSF as a Neuroinflammation-Metabolism Interfa

Score: 0.665 · translational neuroscience · 2026-04-12

## Mechanistic Overview Lactate/Pyruvate Ratio Dynamics in CSF as a Neuroinflammation-Metabolism Interface Biomarker sta

Mitochondrial Biogenesis Rate as a Dynamic Biomarker of Neuroprotection

Score: 0.652 · translational neuroscience · 2026-04-12

## Mechanistic Overview Mitochondrial Biogenesis Rate as a Dynamic Biomarker of Neuroprotection starts from the claim th

Transglutaminase-2 Cross-Linking Inhibition Strategy

Score: 0.639 · neurodegeneration · 2026-04-02

Transglutaminase-2 creates covalent cross-links between lysine and glutamine residues shared across tau, α-synuclein, an

BH4 Cofactor Restoration as Primary Driver of >500-Fold Dopamine Elevation

Score: 0.618 · neurodegeneration · 2026-04-13

## Mechanistic Overview BH4 Cofactor Restoration as Primary Driver of >500-Fold Dopamine Elevation starts from the claim

Correcting Gut Microbial Dopamine Imbalance to Support Systemic Dopaminergic Fun

Score: 0.606 · neurodegeneration · 2026-04-02

## Mechanistic Overview Correcting Gut Microbial Dopamine Imbalance to Support Systemic Dopaminergic Function starts fro

Glycosaminoglycan Template Disruption Approach

Score: 0.597 · neurodegeneration · 2026-04-02

Heparan sulfate and other glycosaminoglycans serve as nucleation templates that facilitate cross-seeding by concentratin