gene 1,529 words KG: PIK3C3
Contents

PIK3C3 — Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3 (VPS34)

🧬 Gene Info
Gene SymbolPIK3C3
Full NamePhosphatidylinositol 3-Kinase Catalytic Subunit Type 3 (VPS34)
AliasesVPS34
Chromosome18q12.3
Protein FamilyClass III Phosphoinositide 3-kinase (PI3K3C)
Subcellular LocalizationCytosol, endosomal membrane, phagophore
Molecular Weight100 kDa
Amino Acids887 aa
Exons32
PathwaysPI3K
UniProt IDQ8N3F7
Ensembl IDENSG00000055070
GeneCardsPIK3C3
Human Protein AtlasPIK3C3
Associated DiseasesAD, ADH, Als, Alzheimer, AMI
Known Drugs/Compoundsrapamycin
InteractionsACAT1, ACETYL-COA, AKT, AKT1, AKT1S1, ALZHEIMER
KG Connections1109 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (17)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
APOE-Dependent Autophagy Restoration
Score: 0.88
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
Transcriptional Autophagy-Lysosome Coupling
Score: 0.76
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.72
Autophagosome Maturation Checkpoint Control
Score: 0.71
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Lysosomal Positioning Dynamics Modulation
Score: 0.69
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
Quantum Coherence Disruption in Cellular Communication
Score: 0.63
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62

Related Analyses (10)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (19)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.40
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40
Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40

See Also (8)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: associated_with
ACTB Gene
gene · KG edge: regulates
AKT1 Gene
gene · KG edge: interacts_with
AMBRA1 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

PIK3C3 regulates CELL_POLARITY
ACTB regulates PIK3C3
PPARA regulates PIK3C3
CAT regulates PIK3C3
SQSTM1 regulates PIK3C3
RPS6KB1 regulates PIK3C3
RAB7A regulates PIK3C3
SREBF1 regulates PIK3C3
EIF4EBP1 regulates PIK3C3
CTSD regulates PIK3C3

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