protein 803 words KG: PIK3C3VPS34
Contents

PIK3C3 Protein

🔬 Protein Info
Gene SymbolPIK3C3VPS34
AliasesPIK3C3VPS34
Kinase Domain (232-780 aa)Catalytic core that phosphorylates PI to generate PI3P
C2 Domain (790-887 aa)Membrane-binding domain that facilitates lipid interaction
N-terminal RegionRegulatory sequences controlling complex formation and localization
Complex IPIK3C3-Beclin1-ATG14L-VPS15 — primarily involved in autophagosome initiation
Complex IIPIK3C3-Beclin1-UVRAG-VPS15 — involved in endosomal and autophagosomal trafficking
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (5)

SASP-Mediated Complement Cascade Amplification
Score: 0.91
APOE-Dependent Autophagy Restoration
Score: 0.85
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (8)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (7)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.40
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40
Mixed Pathology Effects on Parkinson's Disease Progression a
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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