gene

VPS11

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VPS11: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

39Connections

0Hypotheses

0Analyses

25Outgoing

14Incoming

0Experiments

0Debates

Summary

VPS11 is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Ms, Parkinson. Connected to 11 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	VPS11
Full Name	Vacuolar Protein Sorting 11
Chromosome	11p15.5
Function	VPS11 (Vacuolar Protein Sorting 11) is a core component of the HOPS (Homotypic fusion and Vacuole Protein Sorting) complex, which mediates late endosome-lysosome and autophagosome-lysosome fusion.
Pathways	Autophagy, autophagy pathway
UniProt ID	[Q9Y5G6](https://www.uniprot.org/uniprot/Q9Y5G6)
Ensembl ID	ENSG00000160602
GeneCards	VPS11
Human Protein Atlas	VPS11
Endosome-lysosome fusion	Mediates trafficking to lysosomes
Autophagosome-lysosome fusion	Essential for autophagy completion
Lysosomal nutrient sensing	Links nutrient status to degradation
Lysosomal dysfunction	HOPS defects impair α-synuclein clearance
Genetic associations	VPS11 variants in PD patients
Autophagy impairment	Similar to PD mechanisms[@mehta2021]
Associated Diseases	Ms, Parkinson
Interactions	Akt, AKT1, AUTOPHAGY, prM
KG Connections	39 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

VPS11 — Vacuolar Protein Sorting 11

gene · 540 words

→

Pathway Diagram

graph TD
    VPS11["VPS11"]
    Parkinson{"Parkinson"}
    VPS11 -->|"associated with"| Parkinson
    Ms{"Ms"}
    VPS11 -->|"associated with"| Ms
    GENES["GENES"]
    VPS11 -->|"associated with"| GENES
    PIK3C3["PIK3C3"]
    VPS11 -->|"associated with"| PIK3C3
    LRRK2["LRRK2"]
    VPS11 -->|"associated with"| LRRK2
    Mitophagy(["Mitophagy"])
    VPS11 -->|"associated with"| Mitophagy
    Autophagy(["Autophagy"])
    VPS11 -->|"associated with"| Autophagy
    neurodegeneration["neurodegeneration"]
    VPS11 -->|"implicated in"| neurodegeneration
    VPS35["VPS35"]
    VPS35 -->|"associated with"| VPS11
    VPS13D["VPS13D"]
    VPS13D -->|"associated with"| VPS11
    GBA["GBA"]
    GBA -->|"associated with"| VPS11
    style VPS11 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (25)

Target	Relation	Type	Str
autolysosome formation	inhibits	process	0.85
Encephalitis	therapeutic_target	disease	0.65
Parkinson	associated_with	disease	0.65
Ms	associated_with	disease	0.65
GENES	associated_with	gene	0.60
Mitophagy	associated_with	pathway	0.60
Autophagy	associated_with	pathway	0.60
DNA	associated_with	gene	0.60
AND	associated_with	gene	0.60
Akt	activates	protein	0.60
SIRT1	therapeutic_target	gene	0.60
Rb	therapeutic_target	protein	0.60
LRRK2	associated_with	gene	0.60
DNA	therapeutic_target	gene	0.60
Autophagy	activates	pathway	0.60
Immune Response	therapeutic_target	pathway	0.60
T Cell	therapeutic_target	cell_type	0.60
GENETIC MUTATIONS	associated_with	gene	0.60
Immune Response	associated_with	pathway	0.60
AUTOPHAGY	activates	gene	0.60
Actin	therapeutic_target	protein	0.60
autophagy pathway	participates_in	pathway	0.60
PIK3C3	associated_with	gene	0.60
AKT1	activates	gene	0.60
T Cell	expressed_in	cell_type	0.55

Incoming (14)

Source	Relation	Type	Str
prM	interacts_with	protein	0.90
TBEV prM	binds_to	protein	0.88
SIRT1	therapeutic_target	gene	0.60
AKT1	activates	gene	0.60
SIRT1	associated_with	gene	0.60
DNA	therapeutic_target	gene	0.60
DNA	associated_with	gene	0.60
AUTOPHAGY	activates	gene	0.60
AND	associated_with	gene	0.60
GENETIC MUTATIONS	associated_with	gene	0.60
VPS35	associated_with	gene	0.60
VPS13D	associated_with	gene	0.60
GBA	associated_with	gene	0.60
Autophagy	activates	process	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning VPS11 in their description or question text

No additional research found