gene

ESR2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ESR2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

269Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

ESR2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, expressed in. Associated with ALS, Als, Alzheimer. Connected to 108 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	ESR2
Full Name	Estrogen Receptor Beta
Chromosome	14q23.2
Protein Type	Gene
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	substantia nigra dopamine neurons - Neuroprotection: ERβ agonists protect against MPTP-induced parkinsonism - Clinical Relevance: Potential th
Pathways	PI3K, MAPK, Notch
UniProt ID	Q92731
NCBI Gene ID	2113
Ensembl ID	ENSG00000140009
GeneCards	ESR2
Human Protein Atlas	ESR2
DNA Binding Domain	Highly conserved, allowing binding to estrogen response elements
Ligand Binding Domain	Different from ERα, with distinct ligand selectivity
Transactivation Domains	AF-1 and AF-2 regions for co-regulator recruitment
Associated Diseases	ALS, Alzheimer, Cancer, Cardiovascular, Ischemia, Ms
Known Drugs/Compounds	rapamycin
Interactions	AMPK, AMYLOID, AR, ATG, ATG7, ATP6AP2
KG Connections	269 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ESR2 — AlphaFold Q92731 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ESR2 — Estrogen Receptor Beta

gene · 612 words

→

Pathway Diagram

graph TD
    ESR2["ESR2"]
    ESR2 -->|"expressed in"| Tumor["Tumor"]
    ESR2 -->|"activates"| Als["Als"]
    ESR2 -->|"regulates"| Cancer["Cancer"]
    ESR2 -->|"regulates"| Cardiovascular["Cardiovascular"]
    ESR2 -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    ESR2 -->|"target for"| Alzheimer["Alzheimer"]
    ESR2 -->|"target for"| Ms["Ms"]
    ESR2 -->|"activates"| ALS["ALS"]
    ESR2 -->|"activates"| Immune_Response["Immune Response"]
    ESR2 -->|"activates"| Er_Stress["Er Stress"]
    CRH["CRH"] -->|"expressed in"| ESR2
    AVP["AVP"] -->|"expressed in"| ESR2
    POMC["POMC"] -->|"expressed in"| ESR2
    CRHR1["CRHR1"] -->|"expressed in"| ESR2
    NR3C1["NR3C1"] -->|"expressed in"| ESR2
    JUN["JUN"] -->|"activates"| ESR2
    ESR1["ESR1"] -->|"expressed in"| ESR2
    TNF["TNF"] -->|"expressed in"| ESR2
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"target for"| ESR2
    MAP2["MAP2"] -->|"activates"| ESR2

Outgoing (165)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ESR2	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Autophagy	regulates	process	0.75
Hypothalamic-Pituitary-Adrenal Axis	modulates	pathway	0.70
Neurodegeneration	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Ms	associated_with	disease	0.65
ALS	protects_against	disease	0.65
Cancer	protects_against	disease	0.65
Ms	therapeutic_target	disease	0.65
Neurodegeneration	regulates	disease	0.65
Parkinson	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Tumor	expressed_in	disease	0.65
Als	activates	disease	0.65
Ischemia	associated_with	disease	0.65
Cancer	regulates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Aging	protects_against	disease	0.65
ALS	activates	disease	0.65
Alzheimer	protects_against	disease	0.65
Aging	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Cardiovascular	regulates	disease	0.65
FYCO1	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
PSEN2	associated_with	gene	0.60
POMC	expressed_in	entity	0.60
FYCO1	activates	entity	0.60
UVRAG	associated_with	gene	0.60
SOX9	associated_with	gene	0.60
LAMP2	associated_with	gene	0.60
CRHR1	expressed_in	gene	0.60
BCL2L1	associated_with	gene	0.60
AVP	expressed_in	gene	0.60
BCL2	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
APP	associated_with	gene	0.60
ESR1	expressed_in	gene	0.60
VDAC2	associated_with	gene	0.60
UVRAG	activates	entity	0.60
ULK1	activates	entity	0.60
TFEB	associated_with	gene	0.60
VDAC2	activates	entity	0.60
WDR45	activates	entity	0.60
CTSD	associated_with	gene	0.60
ESR1	associated_with	gene	0.60
DRD2	therapeutic_target	gene	0.60
TNF	expressed_in	gene	0.60

Incoming (104)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ESR2	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
AR	activates	gene	0.60
BCL2	activates	gene	0.60
AMPK	associated_with	gene	0.60
LC3B	associated_with	gene	0.60
ESR1	therapeutic_target	gene	0.60
IL1B	therapeutic_target	gene	0.60
NOS2	therapeutic_target	gene	0.60
BDNF	therapeutic_target	gene	0.60
PTGS2	therapeutic_target	gene	0.60
IL6	therapeutic_target	gene	0.60
NOS3	therapeutic_target	gene	0.60
ATG	associated_with	gene	0.60
GABA	associated_with	gene	0.60
CYP19A1	associated_with	gene	0.60
ATG	activates	gene	0.60
ATP6AP2	activates	gene	0.60
CYP19A1	activates	gene	0.60
rapamycin	targets	drug	0.60
ACHE	biomarker_for	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
DRD2	therapeutic_target	gene	0.60
PRESENILIN	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
AMYLOID	associated_with	gene	0.60
NR3C2	expressed_in	gene	0.60
ACHE	therapeutic_target	gene	0.60
INS	therapeutic_target	gene	0.60
APP	activates	entity	0.60
BCL2L1	activates	entity	0.60
BECN1	activates	entity	0.60
CTSD	activates	entity	0.60
AMBRA1	activates	entity	0.60
RAS	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
AMPK	activates	entity	0.60
IL12	expressed_in	gene	0.60
RNA	associated_with	gene	0.60
AGING	protects_against	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
AUTOPHAGY	activates	gene	0.60
RAB9A	associated_with	gene	0.60
AVP	expressed_in	gene	0.60
POMC	expressed_in	gene	0.60
CRHR1	expressed_in	gene	0.60
NR3C1	expressed_in	gene	0.60
JUN	activates	gene	0.60
ESR1	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity