gene

AR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

178Connections

30Hypotheses

12Analyses

50Outgoing

14Incoming

0Experiments

18Debates

Summary

A gene referenced in 165 knowledge graph relationships. Key connections: interacts_with SLIRP (protein); interacts_with IGFBP5 (protein); contributes_to Androgen Deprivation Therapy Resistance (phenotype).

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🧬 Gene Info

Gene Symbol	AR
Chromosome	Xq12
Protein Type	Gene
Function	encodes a nuclear receptor protein that binds testosterone and dihydrotestosterone, mediating the effects of androgen hormones in target tissues.
Primary Expression	brain regions including: - Spinal cord: Motor neurons, including those innervating skeletal muscle - Hypothalamus: Regulatory centers for hor
Molecular Weight	110 kDa
Amino Acids	919 aa
GeneCards	AR
Human Protein Atlas	AR
N-terminal domain (NTD)	Contains the AF-1 activation function and polyQ tract
DNA-binding domain (DBD)	Two zinc finger motifs for GRE binding
Hinge region	Contains the nuclear localization signal
Ligand-binding domain (LBD)	Binds testosterone/DHT; contains AF-2
Spinal cord	Motor neurons, including those innervating skeletal muscle
Hypothalamus	Regulatory centers for hormone release
Associated Diseases	Aromatase Inhibitor Resistance, cancer
Known Drugs/Compounds	rapamycin
Interactions	ACTB, AKT, ALS, AMBRA1, AMPK, APP
SciDEX Hypotheses	Testosterone-Derived DHT Amplifies Microglial Andr
KG Connections	178 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    A["AR"] --> B["Androgen Binding"]
    A --> C["Nuclear Translocation"]
    B --> C
    C --> D["Gene Transcription"]
    D --> E["Mitochondrial Biogenesis"]
    D --> F["Neuronal Survival Genes"]
    E --> G["ATP Production"]
    G --> H["Neuronal Bioenergetics"]
    F --> I["Anti-apoptotic Effect"]
    H --> J["Neuroprotection"]
    I --> J
    A --> K["SLIRP Interaction"]

Outgoing (164)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:AR	data_in	dataset_row	0.00
SLIRP	interacts_with	protein	0.95
IGFBP5	interacts_with	protein	0.95
Metabolic Adaptation	modulates	process	0.90
oxidative stress response	participates_in	pathway	0.90
autophagy pathway	participates_in	pathway	0.90
Androgen Deprivation Therapy Resistance	contributes_to	phenotype	0.90
Aromatase Inhibitor Resistance	associated_with	phenotype	0.85
androgen deprivation therapy resistance	mediates	phenotype	0.80
Prostate Cancer Cell Survival	regulates	phenotype	0.80
IL12A	inhibits	gene	0.80
epigenetic regulation	participates_in	pathway	0.80
MAP1LC3B	activates	gene	0.80
BECN1	activates	gene	0.80
Sex Differences In Autophagy	modulates	mechanism	0.75
Autophagy	regulates	process	0.75
Parkinson's disease	activates	disease	0.70
ATG	activates	gene	0.70
GABA	activates	gene	0.70
stem cells	expressed_in	cell_type	0.70
RNA	activates	gene	0.70
MTOR	activates	gene	0.70
PIK3C3	activates	gene	0.70
BCL2	activates	gene	0.70
LAMP1	activates	gene	0.70
HDAC6	activates	gene	0.70
UVRAG	activates	gene	0.70
SQSTM1	activates	gene	0.70
GLA	activates	gene	0.70
GAPDH	activates	gene	0.70
TFEB	activates	gene	0.70
Parkinson's disease	interacts_with	disease	0.70
MAPK signaling	participates_in	pathway	0.70
CHMP4B	activates	gene	0.70
MAPT	inhibits	gene	0.60
CHD1	activates	gene	0.60
HDAC3	activates	gene	0.60
cerebellum	expressed_in	brain_region	0.60
amygdala	expressed_in	brain_region	0.60
lysosomal dysfunction	activates	process	0.60
MAPT	activates	gene	0.60
FOXO1	inhibits	gene	0.60
cancer	associated_with	disease	0.60
neurodegeneration	interacts_with	disease	0.60
NR3C1	associated_with	gene	0.60
PTGS2	associated_with	gene	0.60
cancer	targets	disease	0.60
PI3K	inhibits	gene	0.60
GABRA6	regulates	gene	0.60
PIK3CG	regulates	gene	0.60

Incoming (14)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:AR	data_in	dataset_row	0.00
SPOP	degrades	protein	0.90
Stress Granules	modulates	process	0.85
SPOP mutations	promotes	phenotype	0.85
PI3K-AKT-mTOR	interacts_with	pathway	0.85
rapamycin	targets	drug	0.70
ALS	activates	gene	0.60
AMPK	activates	gene	0.60
AMBRA1	activates	gene	0.60
APP	activates	gene	0.60
AKT	associated_with	gene	0.60
AKT	inhibits	gene	0.60
ALOX12	associated_with	gene	0.60
ACTB	activates	gene	0.60

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop transcranial focused ultrasound with 40Hz gamma	1.000	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.948	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop optogenetic targeting PV interneurons to restore	0.944	Alzheimer's disease	Circuit-level neural dynamics in neurode
Multi-Biomarker Composite Index Surpassing Amyloid PET for T	0.933	neurodegeneration	What amyloid threshold level is required
Closed-loop focused ultrasound targeting CA1 PV interneurons	0.927	Alzheimer's disease	Circuit-level neural dynamics in neurode

Closed-loop transcranial focused ultrasound targeting EC-II	0.922	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting EC-II SST interneur	0.900	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II SST interneurons to block t	0.896	Alzheimer's disease	Circuit-level neural dynamics in neurode
Multi-Target Hypothesis: Aβ-Induced Cholinergic Damage is Pa	0.887	-	Do β-amyloid plaques and neurofibrillary
H1: TREM2 Agonism to Redirect APOE4-Enhanced Microglia from	0.887	neurodegeneration	How does APOE4's beneficial immune funct
GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Cl	0.869	neuroscience	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II PV interneurons to enhance	0.867	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optogenetic restoration of hippocampal gamma oscillations vi	0.863	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting EC-II PV interneuro	0.863	Alzheimer's disease	Circuit-level neural dynamics in neurode
TREM2 R47H Variant-Driven Metabolic Dysfunction as the Prima	0.858	neurodegeneration	How do different microglial subtypes (DA
Closed-loop tACS targeting EC-II PV interneurons to suppress	0.857	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optogenetic viral vector delivery via tFUS-mediated blood-br	0.846	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optogenetic restoration of hippocampal gamma oscillations vi	0.845	Alzheimer's disease	Circuit-level neural dynamics in neurode
TYROBP (DAP12) Conditional Antagonism for Early-Stage Neurop	0.844	neurodegeneration	TREM2 agonism vs antagonism in DAM micro
miR-155/Interferon-gamma Feedback Loop as a Reversible Molec	0.843	neurodegeneration	How do different microglial subtypes (DA
Circadian Glymphatic Entrainment via Targeted Orexin Recepto	0.841	neurodegeneration	Perivascular spaces and glymphatic clear
Sequential Iron Chelation (Deferoxamine) and GPX4 Restoratio	0.838	neurodegeneration	View
Closed-loop tACS targeting EC-II parvalbumin interneurons to	0.831	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.827	Alzheimer's disease	Circuit-level neural dynamics in neurode
Real-time gamma-guided transcranial focused ultrasound targe	0.827	Alzheimer's disease	Circuit-level neural dynamics in neurode
Beta-frequency entrainment therapy targeting PV interneuron-	0.827	Alzheimer's disease	Circuit-level neural dynamics in neurode
Microglial AIM2 Inflammasome as the Primary Driver of TDP-43	0.824	neurodegeneration	What are the mechanisms by which gut mic
Glymphatic-Mediated Tau Clearance Dysfunction	0.821	neuroscience	Circuit-level neural dynamics in neurode
HSPB1 Phosphorylation Mimetics to Promote Protective TDP-43	0.820	neurodegeneration	What is the therapeutic window between i
Ketone Utilization Index as Metabolic Flexibility Biomarker	0.819	translational neuroscience	Which metabolic biomarkers can distingui

Mentioning Analyses (12)

Scientific analyses that reference this entity

Does APOE4 drive tau propagation

neurodegeneration | 2026-04-16 | 0 hypotheses

Does APOE4 drive tau propagation

neurodegeneration | 2026-04-15 | 0 hypotheses

test debate

neurodegeneration | 2026-04-15 | 0 hypotheses

Do oligodendrocytes require DNA repair enhancement or inhibition for neuroprotec

neurodegeneration | 2026-04-11 | 0 hypotheses

Do PINK1/PARKIN pathway enhancements rescue excitatory neuron vulnerability or c

neurodegeneration | 2026-04-11 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (18)

Multi-agent debates referencing this entity

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

closed · Rounds: 4 · Score: 0.50 · 2026-04-21

Investigate mechanisms of epigenetic reprogramming in aging neurons [TARGET_ART

closed · Rounds: 0 · Score: 0.50 · 2026-04-21

Investigate mechanisms of epigenetic reprogramming in aging neurons

closed · Rounds: 0 · Score: 0.56 · 2026-04-21

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

closed · Rounds: 0 · Score: 0.48 · 2026-04-21

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

closed · Rounds: 0 · Score: 0.51 · 2026-04-21

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

closed · Rounds: 4 · Score: 0.73 · 2026-04-21

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

closed · Rounds: 0 · Score: 0.52 · 2026-04-21

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

closed · Rounds: 0 · Score: 0.66 · 2026-04-21

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

closed · Rounds: 0 · Score: 0.58 · 2026-04-21

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

closed · Rounds: 0 · Score: 0.64 · 2026-04-21

Related Research

Hypotheses and analyses mentioning AR in their description or question text

AR

Understanding Entity Pages

Summary

Wiki Pages (21)

ar

KARS1

UCHL1 (PARK5) Pathway in Parkinson's Disease

PARK7 — Parkinsonism Associated Deglycase (DJ-1)

TAR DNA-Binding Protein 43 (TDP-43)

Aging-Related Tau Astrogliopathy (ARTAG)

ASC (PYCARD)

FBXO7 Protein (PARK15)

CFLAR

SMARCA2 (BRM)

LARS2 — Leucyl-tRNA Synthetase 2, Mitochondrial

ARHGEF9 Gene

TIGAR - TP53-Induced Glycolysis and Apoptosis Regulator

ARNTL Gene — Aryl Hydrocarbon Receptor Nuclear Translocator Like (BMAL1)

ATP13A2 (PARK9) Pathway in Parkinson's Disease

PARK2 - Parkin

ARC-IM Adaptive Neurostimulation for Parkinson's Disease

PGC-1α (PPARGC1A)

PARD6B Gene

SARM1 NADase Inhibition for Axonal Preservation

ARRB2 — Arrestin Beta 2

Pathway Diagram

Outgoing (164)

Incoming (14)

Targeting Hypotheses (30)

Mentioning Analyses (12)

Does APOE4 drive tau propagation

Does APOE4 drive tau propagation

test debate

Do oligodendrocytes require DNA repair enhancement or inhibition for neuroprotec

Do PINK1/PARKIN pathway enhancements rescue excitatory neuron vulnerability or c

Do PINK1/PARKIN pathway enhancements rescue excitatory neuron vulnerability or e

Do these mechanistic hypotheses from the SEA-AD Atlas bundle explain layer-speci

Do these mechanistic hypotheses explain layer-specific synaptic vulnerability in

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Investigate mechanisms of epigenetic reprogramming in aging neurons

Experiments (0)

Related Papers (0)

Debates (18)

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Investigate mechanisms of epigenetic reprogramming in aging neurons [TARGET_ART

Investigate mechanisms of epigenetic reprogramming in aging neurons

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

Related Research

Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to

Closed-loop focused ultrasound targeting EC-II SST interneurons to restore gamma

Closed-loop tACS targeting EC-II SST interneurons to block tau propagation and r

Multi-Target Hypothesis: Aβ-Induced Cholinergic Damage is Partially Irreversible

H1: TREM2 Agonism to Redirect APOE4-Enhanced Microglia from Synapse Pruning to A

GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Clearance

Closed-loop tACS targeting EC-II PV interneurons to enhance perisomatic inhibiti

Optogenetic restoration of hippocampal gamma oscillations via selective PV inter

Closed-loop focused ultrasound targeting EC-II PV interneurons to restore theta-

TREM2 R47H Variant-Driven Metabolic Dysfunction as the Primary Trigger for Faile

Closed-loop tACS targeting EC-II PV interneurons to suppress burst firing and bl

Optogenetic viral vector delivery via tFUS-mediated blood-brain barrier opening

Optogenetic restoration of hippocampal gamma oscillations via selective SST inte

TYROBP (DAP12) Conditional Antagonism for Early-Stage Neuroprotection

miR-155/Interferon-gamma Feedback Loop as a Reversible Molecular Switch for Prot