gene

VDAC1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VDAC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

502Connections

2Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

Page for VDAC1 — Voltage Dependent Anion Channel 1

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🧬 Gene Info

Gene Symbol	VDAC1
Full Name	Voltage Dependent Anion Channel 1
Chromosome	5q31
Protein Type	Channel
Function	VDAC1 encodes the voltage-dependent anion channel 1, also known as porin.
Primary Expression	Brain, Heart, Liver, Kidney
Molecular Weight	31 kDa
Pathways	Apoptosis, Autophagy, Er Stress, Glycolysis, Mitochondrial Function
UniProt ID	P21796
NCBI Gene ID	7416
Ensembl ID	ENSG00000110833
GeneCards	VDAC1
Human Protein Atlas	VDAC1
Associated Diseases	ALS, Alzheimer, Alzheimer's disease, amyotrophic lateral sclerosis
Interactions	aco2, ACO2, AKT, ALS, ALZHEIMER'S DISEASE, AMPK
KG Connections	502 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: VDAC1 — AlphaFold P21796 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

VDAC1 — Voltage Dependent Anion Channel 1

gene · 1007 words

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VDAC1 Protein

protein · 589 words

→

Pathway Diagram

graph TD
    VDAC1["VDAC1"]
    VDAC1 -->|"activates"| Cancer["Cancer"]
    VDAC1 -->|"activates"| Als["Als"]
    VDAC1 -->|"activates"| Inflammation["Inflammation"]
    VDAC1 -->|"activates"| Alzheimer["Alzheimer"]
    VDAC1 -->|"activates"| Neuroinflammation["Neuroinflammation"]
    VDAC1 -->|"target for"| Parkinson["Parkinson"]
    VDAC1 -->|"activates"| Ms["Ms"]
    VDAC1 -->|"activates"| Depression["Depression"]
    VDAC1 -->|"activates"| Hepatitis["Hepatitis"]
    VDAC1 -->|"activates"| Senescence["Senescence"]
    SQSTM1["SQSTM1"] -->|"binds"| VDAC1
    GPCPD1["GPCPD1"] -->|"binds"| VDAC1
    DNM1L["DNM1L"] -->|"activates"| VDAC1
    KRAS["KRAS"] -->|"expressed in"| VDAC1
    DRP1["DRP1"] -->|"activates"| VDAC1
    CXCL10["CXCL10"] -->|"activates"| VDAC1
    DSDNA["DSDNA"] -->|"activates"| VDAC1
    STING["STING"] -->|"activates"| VDAC1
    MTDNA["MTDNA"] -->|"activates"| VDAC1
    CGAS["CGAS"] -->|"activates"| VDAC1

Outgoing (328)

Target	Relation	Type	Str
Cancer	activates	disease	0.95
MAMs	involved_in	process	0.95
mtDNA efflux	mediates	process	0.95
Hepatic Ischemia-Reperfusion Injury	biomarker_for	disease	0.90
GRP75	interacts_with	protein	0.90
CANCER	activates	gene	0.90
Metabolic Flexibility	associated_with	phenotype	0.85
mitochondrial calcium uptake	modulates	process	0.85
Mitochondrial Calcium Uptake	involved_in	process	0.85
Mitophagy	associated_with	process	0.80
Mitochondrial Respiration	involved_in	pathway	0.80
mitochondrial membrane permeability	regulates	biological_process	0.80
calcium balance	regulates	biological_process	0.80
programmed cell death pathways	facilitates	biological_process	0.80
amyloid-β	interacts_with	protein	0.80
α-synuclein	interacts_with	protein	0.80
mutant SOD1	interacts_with	protein	0.80
amyotrophic lateral sclerosis	implicated_in	disease	0.80
Alzheimer's disease	associated_with	disease	0.80
ALZHEIMER	associated_with	disease	0.80
Apoptosis	activates	pathway	0.80
APOPTOSIS	activates	gene	0.80
Cardiac	activates	disease	0.75
Colorectal Cancer	biomarker_for	disease	0.75
Tumor	activates	disease	0.75
Mitophagy	regulates	pathway	0.70
MITOPHAGY	regulates	gene	0.70
Disulfidptosis	involved_in	process	0.70
MITOPHAGY	activates	gene	0.70
mitochondrial-ER contacts	regulates	structure	0.70
MCU	activates	gene	0.70
MITOCHONDRIA	regulates	gene	0.70
PARKIN	regulates	gene	0.70
AUTOPHAGY	activates	gene	0.70
Mitophagy	activates	pathway	0.70
Mtor	activates	pathway	0.70
Er Stress	activates	pathway	0.70
Autophagy	activates	pathway	0.70
ALS	associated_with	disease	0.65
Breast Cancer	activates	disease	0.65
Hepatitis	activates	disease	0.65
Depression	activates	disease	0.65
Ischemia	regulates	disease	0.65
Ms	activates	disease	0.65
Cardiac	regulates	disease	0.65
Tauopathy	activates	disease	0.65
Atherosclerosis	activates	disease	0.65
Parkinson	degrades	disease	0.65
Ischemia	associated_with	disease	0.65
ubiquitin-proteasome	participates_in	pathway	0.65

Incoming (174)

Source	Relation	Type	Str
GAΒ	interacts_with	protein	0.95
SQSTM1	associated_with	gene	0.80
GPCPD1	binds	gene	0.80
ATP	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
MITOPHAGY	associated_with	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
RNA	associated_with	gene	0.60
CGAS-STING	associated_with	gene	0.60
GENES	regulates	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
ANXA5	expressed_in	gene	0.60
CCND1	expressed_in	gene	0.60
DRP1	regulates	gene	0.60
YWHAZ	associated_with	gene	0.60
BAX	activates	gene	0.60
PRKN	regulates	gene	0.60
PARKIN	interacts_with	gene	0.60
FUNDC1	regulates	gene	0.60
DEPRESSION	activates	entity	0.60
SORL1	inhibits	gene	0.60
PRKCI	therapeutic_target	gene	0.60
BRD4	activates	gene	0.60
SIRT2	regulates	gene	0.60
PDK1	regulates	gene	0.60
STAT3	activates	gene	0.60
YWHAZ	expressed_in	gene	0.60
HSP90AB1	expressed_in	gene	0.60
CAV1	expressed_in	gene	0.60
SOD1	interacts_with	gene	0.60
DSDNA	activates	gene	0.60
MTDNA	activates	gene	0.60
MITOCHONDRIAL DNA	activates	gene	0.60
GENES	activates	gene	0.60
DNA	activates	gene	0.60
BCL-2	activates	gene	0.60
CGAS	associated_with	gene	0.60
UCP2	associated_with	gene	0.60
MCU	associated_with	gene	0.60
FUNDC1	associated_with	gene	0.60
PARKINSON	degrades	gene	0.60
ALS	implicated_in	gene	0.60
CXCL10	activates	gene	0.60
STING	activates	gene	0.60
CGAS	activates	gene	0.60
IRF3	activates	gene	0.60
CCL5	activates	gene	0.60
RAGE	therapeutic_target	gene	0.60
APP	inhibits	gene	0.60
NLRP3	regulates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
MCU Calcium Overload via MFN2/GRP75/VDAC1 MAM Dysfunction	0.644	neurodegeneration	What upstream mechanisms cause TDP-43 to
VDAC1 Hyper-Oligomerization via Direct TDP-43 Binding	0.496	neurodegeneration	What upstream mechanisms cause TDP-43 to

Mentioning Analyses (1)

Scientific analyses that reference this entity

Which specific metabolic pathways in APOE4+ microglia are most therapeutically t

neurodegeneration | 2026-04-08 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

While APOE4 disrupts microglial metabolism broadly, the debate didn't identify w

closed · Rounds: 4 · Score: 0.92 · 2026-04-09

Related Research

Hypotheses and analyses mentioning VDAC1 in their description or question text

No additional research found