gene

NOX4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NOX4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

231Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

NOX4 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, interacts with. Associated with Aging, Als, Anxiety. Connected to 104 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NOX4
Full Name	NADPH Oxidase 4
Chromosome	11q14.3
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	neurons, astrocytes, microglia, and endothelial cells within t
Molecular Weight	67 kDa
Amino Acids	578 aa
Pathways	Amyloid, Oxidative Stress
UniProt ID	[Q9NPH5](https://www.uniprot.org/uniprot/Q9NPH5)
Ensembl ID	ENSG00000188882
OMIM	605966
GeneCards	NOX4
Human Protein Atlas	NOX4
N-terminal transmembrane domains (6×)	Span the membrane and contain heme-binding sites
Dehydrogenase domain	Located in the cytoplasm, contains FAD and NADPH binding sites
Associated Diseases	neurodegeneration
Known Drugs/Compounds	CLEMASTINE
Interactions	AGING, AKT, ALOX12, ALOX15, ALS, AMPK
KG Connections	231 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NOX4 Gene

gene · 1032 words

→

Pathway Diagram

flowchart TD
    NOX4["NOX4"] -->|"activates"| oxidative_stress["oxidative stress"]
    NOX4["NOX4"] -->|"activates"| ferroptosis["ferroptosis"]
    NOX4["NOX4"] -.->|"inhibits"| mitochondrial_respiration["mitochondrial respiration"]
    NOX4["NOX4"] -->|"expressed in"| astrocyte["astrocyte"]
    NOX4["NOX4"] -->|"activates"| Diabetes["Diabetes"]
    NOX4["NOX4"] -->|"activates"| Neuroinflammation["Neuroinflammation"]
    NOX4["NOX4"] -->|"activates"| Inflammation["Inflammation"]
    NOX4["NOX4"] -->|"activates"| Aging["Aging"]
    NOX4["NOX4"] -->|"activates"| Ms["Ms"]
    NOX4["NOX4"] -->|"activates"| Anxiety["Anxiety"]
    NOX4["NOX4"] -->|"activates"| Cardiovascular["Cardiovascular"]
    NOX4["NOX4"] -->|"activates"| Neuropathy["Neuropathy"]
    style NOX4 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style oxidative_stress fill:#006494,stroke:#333,color:#e0e0e0
    style ferroptosis fill:#006494,stroke:#333,color:#e0e0e0
    style mitochondrial_respiration fill:#006494,stroke:#333,color:#e0e0e0
    style astrocyte fill:#006494,stroke:#333,color:#e0e0e0
    style Diabetes fill:#ef5350,stroke:#333,color:#e0e0e0
    style Neuroinflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Aging fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Anxiety fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cardiovascular fill:#ef5350,stroke:#333,color:#e0e0e0
    style Neuropathy fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (162)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:NOX4	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Inflammation	activates	disease	0.85
INFLAMMATION	activates	gene	0.80
Aging	activates	disease	0.75
Atherosclerosis	activates	disease	0.75
Cancer	activates	disease	0.75
AUTOPHAGY	activates	gene	0.70
Oxidative Stress	activates	pathway	0.70
ACSL4-mediated ferroptosis	associated_with	mechanism	0.70
NF-ΚB	activates	gene	0.70
Apoptosis	activates	pathway	0.70
Autophagy	activates	pathway	0.70
H2O2	generates	biomarker	0.70
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.70
CANCER	activates	gene	0.70
ubiquitin-proteasome	participates_in	pathway	0.70
Nf-Κb	activates	pathway	0.70
oxidative stress	activates	process	0.70
ferroptosis	activates	process	0.70
mitochondrial respiration	inhibits	process	0.70
astrocyte	expressed_in	cell_type	0.70
Aging	therapeutic_target	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Cardiovascular	inhibits	disease	0.65
Inflammation	regulates	disease	0.65
Ms	inhibits	disease	0.65
Alzheimer	regulates	disease	0.65
Parkinson	activates	disease	0.65
Coronary Artery Disease	therapeutic_target	disease	0.65
Longevity	therapeutic_target	disease	0.65
Neurodegeneration	activates	disease	0.65
Anxiety	activates	disease	0.65
Als	activates	disease	0.65
Senescence	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Cardiac	activates	disease	0.65
Cachexia	therapeutic_target	disease	0.65
Senescence	activates	disease	0.65
Tumor	activates	disease	0.65
Atherosclerosis	inhibits	disease	0.65
Fibrosis	inhibits	disease	0.65
Cardiovascular	activates	disease	0.65
Cardiomyopathy	inhibits	disease	0.65
Neuropathy	activates	disease	0.65
Ms	activates	disease	0.65
Diabetes	inhibits	disease	0.65
Pancreatic Cancer	therapeutic_target	disease	0.65
Diabetes	activates	disease	0.65
Neuroinflammation	activates	disease	0.65

Incoming (69)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:NOX4	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
CLEMASTINE	inhibits	drug	0.80
POLY-PR	upregulates	protein	0.80
SIGMA1R	inhibits	gene	0.80
OXIDATIVE STRESS	activates	gene	0.70
Inflammatory stimuli	induces	mechanism	0.70
BCL-2	inhibits	gene	0.60
NF-ΚB	inhibits	gene	0.60
AND	associated_with	gene	0.60
APOPTOSIS	inhibits	gene	0.60
CYP1A1	associated_with	gene	0.60
NADPH	inhibits	gene	0.60
NEURODEGENERATION	activates	gene	0.60
CCND1	associated_with	gene	0.60
FGFR1	activates	gene	0.60
FGF21	activates	gene	0.60
SOD2	activates	gene	0.60
ICAM1	activates	gene	0.60
VCAM1	activates	gene	0.60
SLC7A11	activates	gene	0.60
NRF2	activates	gene	0.60
GPX1	activates	gene	0.60
MMP2	associated_with	gene	0.60
ROS	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
NEUROTOXICITY	activates	gene	0.60
NEUROINFLAMMATION	regulates	entity	0.60
NEUROINFLAMMATION	activates	gene	0.60
AMPK	activates	gene	0.60
ERK	inhibits	gene	0.60
ROS	inhibits	gene	0.60
CCND1	interacts_with	gene	0.60
CYP1A1	interacts_with	gene	0.60
FGFR3	associated_with	gene	0.60
SOD1	activates	gene	0.60
SLC2A1	associated_with	gene	0.60
RAGE	associated_with	gene	0.60
BAX	inhibits	gene	0.60
GPX1	inhibits	gene	0.60
ALOX12	activates	gene	0.60
ALOX15	activates	gene	0.60
ATM	activates	gene	0.60
ERK	activates	gene	0.60
NF-ΚB	interacts_with	gene	0.60
INSULIN RESISTANCE	activates	gene	0.60
CANCER	activates	gene	0.60
DIABETES MELLITUS	activates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
AMYLOID	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What determines the GPX4/ACSL4 balance that switches microglia from protective t

immunology | 2026-04-15 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

While ACSL4-driven ferroptosis was strongly supported, the molecular triggers th

closed · Rounds: 4 · Score: 0.80 · 2026-04-16

Related Research

Hypotheses and analyses mentioning NOX4 in their description or question text

No additional research found