| Gene Symbol | PERK |
| Protein Type | Kinase |
| Function | Stress sensing: Accumulation of unfolded proteins in the ER lumen |
| Subcellular Localization | the ER membrane. As one of the three major sensors of the unfolded protein response (UPR) |
| Molecular Weight | 125 kDa |
| GeneCards | PERK |
| Human Protein Atlas | PERK |
| N-terminal luminal domain (1-576) | Senses misfolded proteins in the ER lumen; interacts with BiP/GRP78 |
| Transmembrane domain (577-597) | Anchors PERK to ER membrane |
| Cytosolic kinase domain (666-1114) | Serine/threonine kinase activity; phosphorylates eIF2α |
| Associated Diseases | AD, Aging, ALI, Als, Alzheimer |
| Known Drugs/Compounds | Dolutegravir, DTG, rapamycin, SB202190 |
| Interactions | ABCA1, ABCA7, ABCD3, ACETYL-COA, ADSL, AGGF1 |
| KG Connections | 876 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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