protein 1,266 words KG: NLRP6
Contents

NLRP6 Protein (NACHT, LRR and PYD Domains-Containing Protein 6)

🔬 Protein Info
Gene SymbolNLRP6
AliasesPage for NLRP6, Page for NLRP6 Protein, NACHT, LRR and PYD Domains-Containing Protein 6
Protein TypeReceptor
FunctionMucus Secretion: NLRP6 regulates goblet cell mucus granule exocytosis and maintains the mucus barrier[@birchenough2016].
Molecular Weight98 kDa
Amino Acids892 aa
Pathwayswnt
GeneCardsNLRP6
Human Protein AtlasNLRP6
Associated DiseasesAging, ALS, Alzheimer, Autoimmune, Autoimmune Disease, Carcinoma
InteractionsAIM2, AKT, AND, CANCER, CARD8, Caspase
KG Connections162 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (6)

Purinergic Signaling Polarization Control
Score: 0.71
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.67
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62

Related Analyses (7)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

AIM2 Inflammasome Modulation Therapy for Neurodegenerat
idea · KG edge: interacts_with
Alzheimer Indonesia
institution · KG edge: associated_with
CARD8 - Caspase Recruitment Domain Family Member 8
gene · KG edge: activates
GAIN Gene - GABA-A Receptor Associated Protein Like 2
gene · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with

Knowledge Graph (12 edges)

PI3K interacts_with NLRP6
NLRP6 interacts_with AKT
NLRP6 activates OPTN
NLRP6 activates PTEN
NLRP3 activates NLRP6
NLRP1 activates NLRP6
NLRP2 activates NLRP6
GAIN implicated_in NLRP6
NLRP6 activates NLRP7
NLRP6 activates NLRP12

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