concept

IRGM1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IRGM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

57Connections

0Hypotheses

0Analyses

40Outgoing

17Incoming

0Experiments

0Debates

No summary available yet.

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💡 Concept Info

Name	IRGM1
Key Genes/Proteins	AKT, ASC, ATG, BECN1, BRG1, CCDC50
Related Diseases	cancer
Related Pathways	autophagy pathway

Pathway Diagram

graph TD
    IRGM1[IRGM1]
    IRGM1 -->|promotes| Inflammation[Inflammation]
    IRGM1 -->|activates| Pi3K_Akt_Mtor[Pi3K/Akt/Mtor]
    IRGM1 -->|regulates| anti_inflammatory_response[anti-inflammatory response]
    IRGM1 -->|activates| PI3K_AKT_mTOR_Pathway[PI3K/AKT/mTOR Pathway]
    IRGM1 -->|upregulates| Inflammatory_Cytokines[Inflammatory Cytokines]
    IRGM1 -->|upstream_of| PI3K_AKT_mTOR[PI3K/AKT/mTOR]
    IRGM1 -->|inhibits| INFLAMMATION[INFLAMMATION]
    IRGM1 -->|participates in| PI3K_AKT_mTOR_signaling[PI3K-AKT-mTOR signaling]
    IRGM1 -->|inhibits| PI3K[PI3K]
    BBR[BBR] -->|targets| IRGM1
    Berberine[Berberine] -->|targets| IRGM1
    AKT[AKT] -->|inhibits| IRGM1
    ASC[ASC] -->|activates| IRGM1
    BECN1[BECN1] -->|activates| IRGM1
    BRG1[BRG1] -->|activates| IRGM1

Outgoing (40)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:IRGM1	data_in	dataset_row	0.00
Inflammation	promotes	process	0.90
Pi3K/Akt/Mtor	activates	pathway	0.88
PI3K/AKT/mTOR	upstream_of	pathway	0.85
anti-inflammatory response	regulates	process	0.85
Inflammatory Cytokines	upregulates	biomarker	0.85
PI3K/AKT/mTOR Pathway	activates	pathway	0.85
Inflammatory Cytokines	regulates	process	0.80
INFLAMMATION	inhibits	process	0.80
PI3K-AKT-mTOR signaling	participates_in	pathway	0.70
stem cells	expressed_in	cell_type	0.60
PI3K	inhibits	gene	0.60
LC3	activates	gene	0.60
MELK	activates	gene	0.60
MTOR	activates	gene	0.60
NLRP3	activates	gene	0.60
NOD2	activates	gene	0.60
PI3K	activates	gene	0.60
PYCARD	activates	gene	0.60
RIPK2	activates	gene	0.60
RIPK3	activates	gene	0.60
SMARCA4	activates	gene	0.60
SQSTM1	activates	gene	0.60
STAT3	activates	gene	0.60
TNF	activates	gene	0.60
TNFA	activates	gene	0.60
ULK1	activates	gene	0.60
RALGAPA2	activates	gene	0.60
SNF	activates	gene	0.60
SWI	activates	gene	0.60
cancer	activates	disease	0.60
MAP1LC3	activates	gene	0.60
MAPK	activates	gene	0.60
NLR	activates	gene	0.60
NRBF2	activates	gene	0.60
ROS	activates	gene	0.60
autophagy pathway	participates_in	pathway	0.60
MAPK signaling	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
necroptosis	participates_in	pathway	0.60

Incoming (17)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:IRGM1	data_in	dataset_row	0.00
BBR	targets	compound	0.98
BBR	binds_to	drug	0.95
Berberine	targets	compound	0.95
BBR	downregulates	compound	0.95
BBR	inhibits	drug	0.90
Berberine	downregulates	compound	0.90
ASC	activates	gene	0.60
BECN1	activates	gene	0.60
BRG1	activates	gene	0.60
ERN1	activates	gene	0.60
CLDN2	activates	gene	0.60
ATG	activates	gene	0.60
CCDC50	activates	gene	0.60
rapamycin	targets	drug	0.60
IKK	activates	gene	0.60
AKT	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IRGM1 in their description or question text

No additional research found