gene 1,972 words KG: NLRC5
Contents

NLRC5 — NLR Family CARD Domain Containing 5

🧬 Gene Info
Gene SymbolNLRC5
Full NameNLR Family CARD Domain Containing 5
Chromosome16q13
Protein FamilyNLR (NOD-like receptor) family
Functionregulating MHC class I expression and innate immunity
Primary ExpressionUbiquitous, high in immune cells
Molecular Weight220 kDa
Amino Acids2000 aa
PathwaysNF-κB
UniProt ID[Q86TI2](https://www.uniprot.org/uniprot/Q86TI2)
Ensembl IDENSG00000148488
OMIM613851
GeneCardsNLRC5
Human Protein AtlasNLRC5
Associated DiseasesInfectious Disease, Inflammatory Disease
Known Drugs/CompoundsHeme, PAMP
InteractionsAND, ASTROCYTE, ASTROCYTES, CANCER, CD8, CDK5
KG Connections80 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (15)

Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
APOE-TREM2 Interaction Modulation
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
Nucleolar Stress Response Normalization
Score: 0.65
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
TREM2-Dependent Microglial Senescence Transition
Score: 0.58
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56
Piezoelectric Nanochannel BBB Disruption
Score: 0.52

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

IRF1 transcriptional regulation of Nlrc5 and Ciita promoters
exploratory · proposed · Score: 0.90
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (10)

Astrocytes
entity · KG edge: inhibits
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: inhibits
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: regulates
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: activates
Genes
index · KG edge: activates

Knowledge Graph (12 edges)

NPM1 activates NLRC5
NLRC5 activates CD8
NLRC5 activates IRF1
NLRC5 activates CIITA
NLRC5 activates NPM1
CD8 activates NLRC5
CIITA activates NLRC5
IRF1 activates NLRC5
IRF1 binds NLRC5
CDK5 inhibits NLRC5

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