| Gene Symbol | NLRC4 |
| Aliases | NLRC4PROTEIN |
| Protein Type | Receptor |
| Function | encodes a critical pattern recognition receptor that forms the NLRC4 inflammasome, a multiprotein complex essential for innate immunity and inflammatory responses. |
| Primary Expression | microglia - Minimal expression in astrocytes under normal conditions - Induction in infiltrating immune |
| Subcellular Localization | </th><td>Cytoplasm</td></tr> |
| Molecular Weight | 186 kDa |
| Pathways | NF-κB, MAPK pathway |
| Ensembl ID | ENSG00000102948 |
| GeneCards | NLRC4 |
| Human Protein Atlas | NLRC4 |
| Phosphorylation | Multiple serine phosphorylation sites regulate NLRC4 activity |
| Ubiquitination | Different ubiquitination patterns control activation and degradation |
| SUMOylation | Modulates inflammasome assembly |
| Associated Diseases | ALS, Cancer, Cardiovascular, Infection, Inflammation, Ms |
| Interactions | AIM2, ALZHEIMER, AMPK, AMYLOID, AND, APOPTOSIS |
| KG Connections | 212 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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