| Gene Symbol | ent-gene-304eb5d4 |
| Amyloid-beta plaques | Direct NLRP3 activation via crystalline structure recognitionHalle A 2008, The NLRP3 inflammasome is activated by amyloid-β |
| Aβ oligomers | Cellular uptake triggers lysosomal rupture and inflammasome assemblyCai Y 2021, NLRP3 inflammasome mediates Aβ-induced neuroinflammation |
| ATP release | From damaged neurons activates P2X7 receptors leading to NLRP3 activationZhang Y 2019, P2X7 receptor mediates NLRP3 activation in AD microglia |
| Oxidative stress | ROS-mediated thioredoxin oxidation releases NLRP3 inhibitionCai Y 2021, NLRP3 inflammasome mediates Aβ-induced neuroinflammation |
| Lipid peroxidation | Products such as 4-HNE activate NLRP3Cai Y 2021, NLRP3 inflammasome mediates Aβ-induced neuroinflammation |
| MCC950 | Potent NLRP3 inhibitor; shows efficacy in AD modelsColl RC 2015, MCC950 is a potent and selective NLRP3 inhibitor |
| Dapansutrile (OLT1177) | Oral NLRP3 inhibitor in clinical trialsMarchetti C 2018, OLT1177 (dapansutrile) reduces neuroinflammation in AD models |
| CRID3 | Specific NLRP3 inhibitor reducing neuroinflammationCai Y 2021, NLRP3 inflammasome mediates Aβ-induced neuroinflammation |
| Anakinra | IL-1 receptor antagonistRidker PM 2017, Canakinumab reduces cardiovascular events |
| Canakinumab | Anti-IL-1β antibodyRidker PM 2017, Canakinumab reduces cardiovascular events |
| Caspase-1 inhibitors | VX-765, prenalbastatSong L 2019, Caspase-1 inhibition attenuates Aβ-induced neuronal death |
| KG Connections | 20 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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