protein

DJ-1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DJ-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

602Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

DJ-1 (PARK7) protein: structure, function, and role in Parkinson's disease and oxidative stress response

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🔬 Protein Info

Gene Symbol	DJ
Function	Dj 1 Protein (Park7) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
GeneCards	DJ
Human Protein Atlas	DJ
Associated Diseases	Aging, Als, Alzheimer, Ataxia, disease
Interactions	6-OHDA, ACSL4, Alpha-Synuclein, ALPHA-SYNUCLEIN, ALZHEIMER, ALZHEIMER'S DISEASE
KG Connections	602 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (13)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    DJ_1["DJ-1"]
    DJ_1 -.protects against.-> Dementia["Dementia"]
    DJ_1 -->|"regulates"| mitochondrial_function["mitochondrial function"]
    DJ_1 -->|"activates"| Nrf2["Nrf2"]
    DJ_1 -->|"target for"| Parkinson["Parkinson"]
    DJ_1 -->|"target for"| Ms["Ms"]
    DJ_1 -->|"target for"| Neurodegeneration["Neurodegeneration"]
    DJ_1 -->|"target for"| Aging["Aging"]
    DJ_1 -->|"interacts"| Als["Als"]
    DJ_1 -->|"activates"| Alzheimer["Alzheimer"]
    NRF2["NRF2"] -->|"activates"| DJ_1
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"target for"| DJ_1
    PINK1["PINK1"] -->|"activates"| DJ_1
    ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"] -->|"target for"| DJ_1
    NEURODEGENERATION["NEURODEGENERATION"] -->|"target for"| DJ_1
    PARKIN["PARKIN"] -->|"activates"| DJ_1
    LRRK2["LRRK2"] -->|"target for"| DJ_1
    POLG["POLG"] -->|"target for"| DJ_1
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"] -->|"target for"| DJ_1
    PTEN["PTEN"] -->|"activates"| DJ_1

Outgoing (403)

Target	Relation	Type	Str
Parkinson	associated_with	disease	0.85
Ferroptosis	inhibits	process	0.85
Dementia	protects_against	disease	0.80
brain-derived extracellular vesicles	expressed_in	compound	0.80
Oxidative Stress Response	regulates	process	0.78
Microglial Autophaxy and Phagocytosis	contributes_to	process	0.75
Parkinson	expressed_in	disease	0.75
Parkinson	therapeutic_target	disease	0.75
Oxidative Stress	regulates	pathway	0.70
Chaperone	regulates	pathway	0.70
Mitochondrial Homeostasis	regulates	biological_process	0.70
PARKIN	associated_with	gene	0.70
PARKINSON	activates	gene	0.70
Nrf2	activates	transcription_factor	0.70
Parkinson's disease	associated_with	disease	0.70
mitochondrial function	regulates	process	0.70
mitochondrial dysfunction	associated_with	process	0.70
LRRK2	associated_with	gene	0.70
Stroke	activates	disease	0.65
Ms	activates	disease	0.65
Parkinson	activates	disease	0.65
Ms	expressed_in	disease	0.65
Epilepsy	activates	disease	0.65
Als	activates	disease	0.65
Als	inhibits	disease	0.65
Cancer	expressed_in	disease	0.65
Huntington	associated_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Alzheimer	treats	disease	0.65
Neuropathy	activates	disease	0.65
Huntington	activates	disease	0.65
Cancer	activates	disease	0.65
Type 2 Diabetes	activates	disease	0.65
Depression	treats	disease	0.65
Ataxia	activates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	activates	disease	0.65
ALS	associated_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Alzheimer	activates	disease	0.65
Tumor	expressed_in	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Obesity	activates	disease	0.65
Insulin Resistance	activates	disease	0.65
Diabetes	activates	disease	0.65
Autism	regulates	disease	0.65

Incoming (199)

Source	Relation	Type	Str
HIF-1Α/SIMA	interacts_with	protein	0.80
PARKINSON	associated_with	gene	0.80
PARKINSON'S DISEASE	associated_with	gene	0.70
PARKINSON'S DISEASE	therapeutic_target	gene	0.70
PARKINSON'S DISEASE	expressed_in	gene	0.70
PARKINSON	expressed_in	gene	0.70
PPAR	activates	gene	0.70
OXIDATIVE STRESS	regulates	gene	0.70
PRKN	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
TNF-Α	activates	gene	0.60
MICROGLIA	activates	gene	0.60
ROS	inhibits	gene	0.60
NEURODEGENERATION	protects_against	gene	0.60
PARKINSON'S DISEASE	protects_against	gene	0.60
PARKINSON	protects_against	gene	0.60
MITOCHONDRIA	inhibits	gene	0.60
MTDNA	activates	gene	0.60
TFAM	activates	gene	0.60
HUNTINGTON	activates	gene	0.60
DNA	activates	gene	0.60
ATP	activates	gene	0.60
AMPK	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
ROS	activates	gene	0.60
SIRT1	activates	gene	0.60
EPILEPSY	activates	gene	0.60
INSULIN RESISTANCE	activates	gene	0.60
APP	inhibits	gene	0.60
DEPRESSION	inhibits	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
BRAIN INJURY	regulates	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
PPAR-Γ	activates	gene	0.60
PARK7	associated_with	gene	0.60
TNF	activates	gene	0.60
PINK1	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
NEURODEGENERATIVE DISORDERS	implicated_in	gene	0.60
GENES	associated_with	gene	0.60
ALZHEIMER'S DISEASE	implicated_in	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
ALZHEIMER	inhibits	gene	0.60
NEUROINFLAMMATION	associated_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	therapeutic_target	gene	0.60
PARKIN	activates	gene	0.60
NLRP3	activates	gene	0.60
PARK2	expressed_in	gene	0.60
HIF	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DJ-1 in their description or question text

No additional research found

DJ-1

Understanding Entity Pages

Summary

Wiki Pages (13)

DJ-1 Oxidative Stress Response Pathway in Parkinson's Disease

PARK7 — Parkinsonism Associated Deglycase (DJ-1)

DJ-1-PTEN-P53 Network

PARK7 (DJ-1) Targeted Therapy for Parkinson's Disease

DJ-1 Protein

DJ-1/PARK7 Neuroprotection Pathway in Parkinson's Disease

PARK7/DJ-1 Neuroprotection Pathway — Parkinson's Disease Causal Chain

PARK7 — Parkinsonism Associated Deglycase (DJ-1)

DJ-1 Protein (PARK7)

PARK7 Gene - DJ-1/PARK7

DJ-1 (PARK7) Neuroprotective Therapies

PARK7 (DJ-1) Protein

PARK7 Protein (DJ-1)