protein

DJ-1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DJ-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

597Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

DJ-1 (PARK7) protein: structure, function, and role in Parkinson's disease and oxidative stress response

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	DJ
Function	Dj 1 Protein (Park7) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
GeneCards	DJ
Human Protein Atlas	DJ
Associated Diseases	Aging, Als, Alzheimer, Ataxia, disease
Interactions	6-OHDA, ACSL4, Alpha-Synuclein, ALPHA-SYNUCLEIN, ALZHEIMER, ALZHEIMER'S DISEASE
KG Connections	597 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (13)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    DJ_1["DJ-1"]
    DJ_1 -.protects against.-> Dementia["Dementia"]
    DJ_1 -->|"regulates"| mitochondrial_function["mitochondrial function"]
    DJ_1 -->|"activates"| Nrf2["Nrf2"]
    DJ_1 -->|"target for"| Parkinson["Parkinson"]
    DJ_1 -->|"target for"| Ms["Ms"]
    DJ_1 -->|"target for"| Neurodegeneration["Neurodegeneration"]
    DJ_1 -->|"target for"| Aging["Aging"]
    DJ_1 -->|"interacts"| Als["Als"]
    DJ_1 -->|"activates"| Alzheimer["Alzheimer"]
    NRF2["NRF2"] -->|"activates"| DJ_1
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"target for"| DJ_1
    PINK1["PINK1"] -->|"activates"| DJ_1
    ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"] -->|"target for"| DJ_1
    NEURODEGENERATION["NEURODEGENERATION"] -->|"target for"| DJ_1
    PARKIN["PARKIN"] -->|"activates"| DJ_1
    LRRK2["LRRK2"] -->|"target for"| DJ_1
    POLG["POLG"] -->|"target for"| DJ_1
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"] -->|"target for"| DJ_1
    PTEN["PTEN"] -->|"activates"| DJ_1

Outgoing (400)

Target	Relation	Type	Str
Parkinson	associated_with	disease	0.85
Ferroptosis	inhibits	process	0.85
brain-derived extracellular vesicles	expressed_in	compound	0.80
Dementia	protects_against	disease	0.80
Oxidative Stress Response	regulates	process	0.78
Parkinson	therapeutic_target	disease	0.75
Parkinson	expressed_in	disease	0.75
Microglial Autophaxy and Phagocytosis	contributes_to	process	0.75
PARKIN	associated_with	gene	0.70
mitochondrial dysfunction	associated_with	process	0.70
Chaperone	regulates	pathway	0.70
mitochondrial function	regulates	process	0.70
Nrf2	activates	transcription_factor	0.70
PARKINSON	activates	gene	0.70
LRRK2	associated_with	gene	0.70
Mitochondrial Homeostasis	regulates	process	0.70
Oxidative Stress	regulates	pathway	0.70
Parkinson's disease	associated_with	disease	0.70
Ms	activates	disease	0.65
Ataxia	activates	disease	0.65
Alzheimer	activates	disease	0.65
Neuropathy	activates	disease	0.65
Obesity	activates	disease	0.65
Diabetes	activates	disease	0.65
Stroke	activates	disease	0.65
Als	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Ms	regulates	disease	0.65
Parkinson	protects_against	disease	0.65
Als	regulates	disease	0.65
Neurodegeneration	protects_against	disease	0.65
Epilepsy	activates	disease	0.65
Traumatic Brain Injury	regulates	disease	0.65
Huntington	activates	disease	0.65
Cancer	activates	disease	0.65
Parkinson	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Type 2 Diabetes	activates	disease	0.65
Als	interacts_with	disease	0.65
Aging	therapeutic_target	disease	0.65
Insulin Resistance	activates	disease	0.65
Huntington	associated_with	disease	0.65
Ms	expressed_in	disease	0.65
Inflammation	activates	disease	0.65
Depression	regulates	disease	0.65
Alzheimer	interacts_with	disease	0.65
Autism	regulates	disease	0.65
Multiple Sclerosis	regulates	disease	0.65
Parkinson	biomarker_for	disease	0.65

Incoming (197)

Source	Relation	Type	Str
HIF-1Α/SIMA	interacts_with	protein	0.80
PARKINSON	associated_with	gene	0.80
PARKINSON'S DISEASE	associated_with	gene	0.70
OXIDATIVE STRESS	regulates	gene	0.70
PARKINSON	expressed_in	gene	0.70
PARKINSON'S DISEASE	expressed_in	gene	0.70
PPAR	activates	gene	0.70
PARKINSON'S DISEASE	therapeutic_target	gene	0.70
ALPHA-SYNUCLEIN	therapeutic_target	gene	0.60
NEURODEGENERATION	therapeutic_target	gene	0.60
PARKIN	activates	gene	0.60
LRRK2	therapeutic_target	gene	0.60
POLG	therapeutic_target	gene	0.60
MITOCHONDRIAL DYSFUNCTION	therapeutic_target	gene	0.60
PTEN	activates	gene	0.60
SNCA	therapeutic_target	gene	0.60
PINK1	interacts_with	gene	0.60
ALPHA-SYNUCLEIN	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
UBIQUITIN	therapeutic_target	gene	0.60
MITOPHAGY	therapeutic_target	gene	0.60
LRRK2	interacts_with	gene	0.60
OXIDATIVE STRESS	interacts_with	gene	0.60
PRKN	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
TNF-Α	activates	gene	0.60
MICROGLIA	activates	gene	0.60
ALPHA-SYNUCLEIN	regulates	gene	0.60
GAIN	therapeutic_target	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
NEURODEGENERATION	biomarker_for	gene	0.60
PARKINSON	biomarker_for	gene	0.60
APP	inhibits	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
DNA	inhibits	gene	0.60
PARKINSON	causes	gene	0.60
INFLAMMATION	associated_with	gene	0.60
PARKINSON	interacts_with	gene	0.60
DNA	associated_with	gene	0.60
INFLAMMATION	activates	gene	0.60
RNA	associated_with	gene	0.60
DEPRESSION	regulates	gene	0.60
NF-ΚB	regulates	gene	0.60
ATP13A2	associated_with	gene	0.60
OXIDATIVE STRESS	causes	gene	0.60
PPAR-Γ	activates	gene	0.60
PARKIN	expressed_in	gene	0.60
PGC1ALPHA	regulates	gene	0.60
ASTROCYTES	expressed_in	gene	0.60
AND	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DJ-1 in their description or question text

No additional research found

DJ-1

Understanding Entity Pages

Summary

Wiki Pages (13)

DJ-1 Oxidative Stress Response Pathway in Parkinson's Disease

PARK7 — Parkinsonism Associated Deglycase (DJ-1)

DJ-1-PTEN-P53 Network

PARK7 (DJ-1) Targeted Therapy for Parkinson's Disease

DJ-1 Protein

DJ-1/PARK7 Neuroprotection Pathway in Parkinson's Disease

PARK7/DJ-1 Neuroprotection Pathway — Parkinson's Disease Causal Chain

PARK7 — Parkinsonism Associated Deglycase (DJ-1)

DJ-1 Protein (PARK7)

PARK7 Gene - DJ-1/PARK7

DJ-1 (PARK7) Neuroprotective Therapies

PARK7 (DJ-1) Protein

PARK7 Protein (DJ-1)