gene

AIF1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AIF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

472Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

AIF1 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, activates, associated with. Associated with ALS, Aging, Als. Connected to 142 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	AIF1
Function	encodes a calcium-binding cytoskeletal adaptor that is strongly enriched in microglia.
Pathways	Autophagy, Inflammasome, Mitophagy, Neuroinflammatory
Ensembl ID	ENSG00000240065
GeneCards	AIF1
Human Protein Atlas	AIF1
Associated Diseases	Aging, Als, Alzheimer, PARKINSON DISEASE
Known Drugs/Compounds	rapamycin
Interactions	ACTB, AD, AGING, AMPK, AND, ARC
KG Connections	472 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

AIF1 Gene

gene · 991 words

→

Pathway Diagram

graph TD
    AIF1["AIF1"] -.->|"inhibits"| Neurodegeneration["Neurodegeneration"]
    AIF1["AIF1"] -.->|"inhibits"| Inflammation["Inflammation"]
    AIF1["AIF1"] -.->|"inhibits"| Als["Als"]
    AIF1["AIF1"] -.->|"inhibits"| Aging["Aging"]
    AIF1["AIF1"] -.->|"inhibits"| Tumor["Tumor"]
    AIF1["AIF1"] -.->|"inhibits"| Parkinson["Parkinson"]
    CKLF["CKLF"] -->|"contributes to"| AIF1["AIF1"]
    ACTB["ACTB"] -->|"associated"| AIF1["AIF1"]
    IL1B["IL1B"] -.->|"inhibits"| AIF1["AIF1"]
    IL6["IL6"] -.->|"inhibits"| AIF1["AIF1"]
    style AIF1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (376)

Target	Relation	Type	Str
MICROGLIA	expressed_in	cell_type	0.90
Microglial Activation	biomarker_for	process	0.85
CSF1R	activates	gene	0.70
CX3CR1	activates	gene	0.70
LAMP1	activates	gene	0.70
OLIGODENDROCYTE	activates	cell_type	0.70
MICROGLIA	protects_against	cell_type	0.70
ATG5	protects_against	gene	0.70
ULK1	activates	gene	0.70
OLIGODENDROCYTE	expresses	cell_type	0.70
MLKL	expresses	gene	0.70
MACROPHAGE	activates	cell_type	0.70
TREM2	markers	gene	0.70
MICROGLIA	markers	cell_type	0.70
TNF	markers	gene	0.70
LAMP1	regulates	gene	0.70
NRF2	markers	gene	0.70
FOXP3	activates	gene	0.70
IBA1	markers	gene	0.70
MACROPHAGE	markers	cell_type	0.70
GFAP	expresses	gene	0.70
APOE	associated_with	gene	0.70
TFEB	activates	gene	0.70
OPTN	inhibits	gene	0.70
MAPT	activates	gene	0.70
PSEN1	regulates	gene	0.70
SNAP25	regulates	gene	0.70
SYN1	regulates	gene	0.70
SYT1	regulates	gene	0.70
VAMP2	regulates	gene	0.70
BACE1	degrades	gene	0.70
GFAP	degrades	gene	0.70
LAMP1	degrades	gene	0.70
GFAP	mediates	gene	0.70
PDGF	associated_with	gene	0.70
TAU	activates	gene	0.70
PSEN1	activates	gene	0.70
GRIN2B	regulates	gene	0.70
HSPA1A	interacts_with	gene	0.70
Neuroinflammation	activates	disease	0.65
Ms	activates	disease	0.65
Inflammation	activates	disease	0.65
Als	activates	disease	0.65
ALS	activates	disease	0.65
ALS	associated_with	disease	0.65
TNF-ALPHA	regulates	gene	0.65
NEURON	associated_with	cell_type	0.65
Aging	associated_with	disease	0.65
NEURONS	associated_with	cell_type	0.65
Als	therapeutic_target	disease	0.65

Incoming (96)

Source	Relation	Type	Str
CKLF	contributes_to	protein	0.80
ADAM10	regulates	gene	0.60
MITOPHAGY	inhibits	gene	0.60
CYTOKINES	inhibits	gene	0.60
PROINFLAMMATORY CYTOKINES	inhibits	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
LYSOSOME	activates	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
GFP	associated_with	gene	0.60
NLR	inhibits	gene	0.60
COMPLEMENT	biomarker_for	gene	0.60
IL1B	inhibits	gene	0.60
IL6	inhibits	gene	0.60
CASP1	associated_with	gene	0.60
ATG5	associated_with	gene	0.60
GFAP	associated_with	gene	0.60
SNCA	inhibits	gene	0.60
BECN1	associated_with	gene	0.60
SQSTM1	inhibits	gene	0.60
TNF	inhibits	gene	0.60
MAP1LC3B	inhibits	gene	0.60
NLRP3	inhibits	gene	0.60
ATG7	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
PYCARD	inhibits	gene	0.60
ASC	inhibits	gene	0.60
DNM1L	activates	gene	0.60
SQSTM1	activates	gene	0.60
PTEN	activates	gene	0.60
OPTN	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
PINK1	activates	gene	0.60
PRKN	activates	gene	0.60
BECN1	activates	gene	0.60
HSPA1A	therapeutic_target	gene	0.60
NEU1	associated_with	gene	0.60
UBIQUITIN	inhibits	gene	0.60
IBA1	associated_with	gene	0.60
APP	associated_with	gene	0.60
ACTB	associated_with	gene	0.60
C1QA	associated_with	gene	0.60
ACTB	regulates	gene	0.60
LC3B	inhibits	gene	0.60
CKLF1	activates	gene	0.60
ALZHEIMER DISEASE	associated_with	gene	0.60
AND	inhibits	gene	0.60
TNF-ALPHA	inhibits	gene	0.60
MICROGLIA	inhibits	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Epigenetic Silencing of AIF1 Gene Locus by Chronic Inflammat	0.643	neuroinflammation	What causes IBA1 low/negative microglia

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity