gene

PYCARD

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PYCARD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

754Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

PYCARD is a gene implicated in neurodegeneration research. Key relationships include: associated with, inhibits, regulates. Associated with ALS, Aging, Als. Connected to 218 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PYCARD
Protein Family	PYD/CARD adaptor family
Protein Type	Signaling Protein
Target Class	Signaling Protein
Function	PYCARD functions as the central adaptor in inflammasome signaling.
Mechanism of Action	PYCARD acts as a critical adaptor protein in inflammasome activation, facilitating pro-inflammatory caspase-1 recruitment and subsequent IL-1β/IL-18 processing, which contributes to neuroinflammatory processes in neurodegenerative conditions like Alzheimer's and Parkinson's disease. Its protein-protein interaction domains mediate inflammatory signal transduction, potentially amplifying neuronal damage through excessive immune response activation.
Subcellular Localization	Cytoplasm (inflammasome specks)
Druggability	Low (0.35)
Clinical Stage	Phase II
Molecular Weight	22 kDa
Amino Acids	90 aa
Pathways	Apoptosis, Inflammasome, Inflammatory response, PANoptosis, Pyroptosis
UniProt ID	Q9ULZ3
GeneCards	PYCARD
Human Protein Atlas	PYCARD
Associated Diseases	Aging, ALS, Alzheimer, Alzheimer's disease, Atherosclerosis, Cancer
Known Drugs/Compounds	rapamycin
Interactions	ACHE, ACTB, AGING, AIF1, AIM2, ALZHEIMER
SciDEX Target	View Target Profile (1 clinical trials)
KG Connections	754 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: PYCARD — AlphaFold Q9ULZ3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PYCARD["PYCARD"]
    PYCARD -->|"interacts"| NLRP3["NLRP3"]
    PYCARD -->|"interacts"| CASP1["CASP1"]
    PYCARD -->|"interacts"| IL1B["IL1B"]
    PYCARD -->|"inhibits"| Neurodegeneration["Neurodegeneration"]
    PYCARD -->|"inhibits"| Inflammation["Inflammation"]
    PYCARD -->|"inhibits"| Als["Als"]
    PYCARD -->|"inhibits"| Aging["Aging"]
    PYCARD -->|"regulates"| Tumor["Tumor"]
    PYCARD -->|"regulates"| Parkinson["Parkinson"]
    PYCARD -->|"activates"| Ms["Ms"]
    h_e7e1f943["h-e7e1f943"] -->|"target for"| PYCARD
    NLRP3 -->|"interacts"| PYCARD
    CASP1 -->|"interacts"| PYCARD
    IL1B -->|"interacts"| PYCARD
    ACTB["ACTB"] -->|"inhibits"| PYCARD
    IL6["IL6"] -->|"regulates"| PYCARD
    ATG5["ATG5"] -->|"inhibits"| PYCARD
    GFAP["GFAP"] -->|"inhibits"| PYCARD

Outgoing (432)

Target	Relation	Type	Str
Parkinson'S Disease	biomarker_for	disease	0.88
Tumor	associated_with	disease	0.85
Inflammation	activates	disease	0.85
ubiquitin-proteasome	participates_in	pathway	0.80
oxidative stress response	participates_in	pathway	0.80
autophagy pathway	participates_in	pathway	0.80
NLRP3 inflammasome activation	involved_in	process	0.80
Nlrp3 Inflammasome	involved_in	process	0.80
pyroptosis	participates_in	pathway	0.80
TNF	associated_with	gene	0.80
XIAP	activates	gene	0.70
SQSTM1	interacts_with	gene	0.70
SQSTM1	transports	gene	0.70
STING	interacts_with	gene	0.70
macrophages	expressed_in	cell_type	0.70
IL1B	associated_with	gene	0.70
AUTOPHAGY	associated_with	gene	0.70
Inflammasome	inhibits	pathway	0.70
Autophagy	inhibits	pathway	0.70
Inflammasome	activates	pathway	0.70
Autophagy	associated_with	pathway	0.70
CASP1	associated_with	gene	0.70
IBD	associated_with	disease	0.70
NOD2	associated_with	gene	0.70
NLRP3	interacts_with	gene	0.65
IL1B	interacts_with	gene	0.65
CASP1	interacts_with	gene	0.65
neurodegeneration	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Pyroptosis	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Stroke	regulates	disease	0.65
Als	regulates	disease	0.65
Ms	activates	disease	0.65
Necroptosis	activates	disease	0.65
Alzheimer	expressed_in	disease	0.65
Alzheimer	associated_with	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Alzheimer	regulates	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Infection	activates	disease	0.65
Melanoma	associated_with	disease	0.65
ALS	inhibits	disease	0.65
Parkinson	inhibits	disease	0.65
Inflammatory Bowel Disease	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Colorectal Cancer	associated_with	disease	0.65
Bacterial Infection	activates	disease	0.65

Incoming (322)

Source	Relation	Type	Str
NLRP3	associated_with	gene	0.90
h-e7e1f943	targets_gene	hypothesis	0.90
h-var-adfecef68a	targets_gene	hypothesis	0.90
h-var-d04a952932	targets_gene	hypothesis	0.90
h-var-08a4d5c07a	targets_gene	hypothesis	0.90
h-var-6957745fea	targets_gene	hypothesis	0.90
h-var-a0933e666d	targets_gene	hypothesis	0.90
h-var-af9eb8e59b	targets_gene	hypothesis	0.90
ASC	associated_with	gene	0.80
INFLAMMATION	activates	gene	0.80
LRP1	expressed_in	gene	0.70
NFKB	activates	gene	0.70
NLRP3	expressed_in	gene	0.70
LRRK2	activates	gene	0.70
MACROPHAGE	inhibits	cell_type	0.70
OPTN	transports	gene	0.70
BACE1	activates	gene	0.70
KEAP1	activates	gene	0.70
PINK1	activates	gene	0.70
MACROPHAGE	activates	cell_type	0.70
GSK3B	activates	gene	0.70
LAMP1	activates	gene	0.70
OPTN	activates	gene	0.70
ACHE	activates	gene	0.70
AMPK	activates	gene	0.70
CGAS	activates	gene	0.70
FOXP3	activates	gene	0.70
LAMP1	associated_with	gene	0.70
ASC	activates	gene	0.70
IL1B	associated_with	gene	0.70
AIM2	associated_with	gene	0.70
ULK1	associated_with	gene	0.70
SQSTM1	associated_with	gene	0.70
LC3	associated_with	gene	0.70
AUTOPHAGY	inhibits	gene	0.70
rapamycin	targets	drug	0.70
NLR	activates	gene	0.70
CASP1	interacts_with	gene	0.65
IL1B	interacts_with	gene	0.65
NLRP3	interacts_with	gene	0.65
MTOR	interacts_with	gene	0.65
BECN1	activates	gene	0.65
LC3	activates	gene	0.65
MAPK	activates	gene	0.65
CANCER	activates	disease	0.65
DENDRITIC CELL	activates	cell_type	0.65
CASP1	associated_with	gene	0.60
AIF1	regulates	gene	0.60
NLRP3	activates	gene	0.60
ATG5	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.888

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What are the mechanisms underlying what are the mechanisms by which gut microbio

closed · Rounds: 4 · Score: 0.95 · 2026-04-01

Related Research

Hypotheses and analyses mentioning PYCARD in their description or question text

No additional research found