concept

CCDC50

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CCDC50: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

62Connections

0Hypotheses

0Analyses

50Outgoing

6Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CCDC50
Key Genes/Proteins	APOE, ASC, ATG, BECN1, BRG1, CLDN2
Related Diseases	cancer, Cell Survival, CRC
Related Pathways	autophagy pathway

Pathway Diagram

graph TD
    CCDC50["CCDC50"]
    CCDC50 -->|"binds"| Polyubiquitinated_Protein_Aggr["Polyubiquitinated Protein Aggregates"]
    CCDC50 -->|"mediates"| Aggrephagy["Aggrephagy"]
    CCDC50 -->|"mediates"| Protein_Aggregates["Protein Aggregates"]
    CCDC50 -.protects against.-> Proteotoxicity["Proteotoxicity"]
    CCDC50 -->|"mediates"| AUTOPHAGY["AUTOPHAGY"]
    CCDC50 -->|"mediates"| Autophagy["Autophagy"]

Outgoing (56)

Target	Relation	Type	Str
Aggrephagy	mediates	process	0.95
Polyubiquitinated Protein Aggregates	binds	compound	0.95
Protein Aggregates	mediates	compound	0.95
Aggrephagy	involved_in	process	0.90
Autophagy	mediates	process	0.90
Proteotoxic Stress	protects_against	process	0.90
Proteotoxicity	protects_against	phenotype	0.90
Protein Aggregates	targets	compound	0.90
AUTOPHAGY	mediates	process	0.90
protein aggregates	mediates	compound	0.90
Cell Survival	associated_with	phenotype	0.90
Macroautophagy	regulates	process	0.85
Neuron	expressed_in	cell_type	0.85
Proteinopathy	protects_against	disease	0.80
Lipid Deposits	downregulates	phenotype	0.80
Neurodegenerative Diseases	associated_with	disease	0.75
autophagy pathway	participates_in	pathway	0.70
ubiquitin-proteasome	participates_in	pathway	0.60
neurons	expressed_in	cell_type	0.60
ERN1	activates	gene	0.60
IRGM1	activates	gene	0.60
LC3	activates	gene	0.60
MAP1LC3	activates	gene	0.60
MAPK	activates	gene	0.60
MELK	activates	gene	0.60
MTOR	activates	gene	0.60
NLR	activates	gene	0.60
NLRP3	activates	gene	0.60
NOD2	activates	gene	0.60
NRBF2	activates	gene	0.60
PI3K	activates	gene	0.60
PYCARD	activates	gene	0.60
RIPK2	activates	gene	0.60
RIPK3	activates	gene	0.60
ROS	activates	gene	0.60
SMARCA4	activates	gene	0.60
SQSTM1	activates	gene	0.60
STAT3	activates	gene	0.60
TNF	activates	gene	0.60
TNFA	activates	gene	0.60
ULK1	activates	gene	0.60
MAPK signaling	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
necroptosis	participates_in	pathway	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
stem cells	expressed_in	cell_type	0.60
CR1	interacts_with	gene	0.60
GMNC	interacts_with	gene	0.60
MAP1LC3B	interacts_with	gene	0.60
CRC	associated_with	disease	0.60

Incoming (6)

Source	Relation	Type	Str
ASC	activates	gene	0.60
ATG	activates	gene	0.60
BECN1	activates	gene	0.60
BRG1	activates	gene	0.60
rapamycin	targets	drug	0.60
APOE	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CCDC50 in their description or question text

No additional research found