gene

USP30

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about USP30: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

147Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Gene profile: USP30 — Ubiquitin Specific Peptidase 30, a mitochondria-localized deubiquitinase critical for mitophagy regulation and a promising therapeutic target in Parkinson's disease

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🧬 Gene Info

Gene Symbol	USP30
Full Name	Ubiquitin Specific Peptidase 30
Chromosome	12p11.23
Protein Type	Enzyme
Function	is a critical deubiquitinating enzyme (DUB) uniquely localized to the outer mitochondrial membrane (OMM), where it serves as a key regulator of mitochondrial quality control through mitophagy [@bin...
Subcellular Localization	the outer mitochondrial membrane (OMM), where it serves as a key regulator of mitochondrial quality control through mito
Molecular Weight	58 kDa
Amino Acids	517 aa
Pathways	Autophagy, Mitophagy
Ensembl ID	ENSG00000196811
GeneCards	USP30
Human Protein Atlas	USP30
N-terminus	Cytoplasmic (facing the cytosol)
C-terminus	Intermembrane space-facing
Substrate specificity	Prefers K6- and K63-linked ubiquitin chains
Associated Diseases	Als, Cardiac, Ms
Interactions	AND, ATF3, AUTOPHAGY, COX4I1, CYTOCHROME C, FOXO3
SciDEX Hypotheses	Mitophagy Induction as Neuroprotective Strategy in
KG Connections	147 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    USP30["USP30"] -->|"activates"| Aging["Aging"]
    USP30["USP30"] -->|"activates"| Cardiovascular["Cardiovascular"]
    USP30["USP30"] -->|"therapeutic target"| Parkinson["Parkinson"]
    USP30["USP30"] -->|"therapeutic target"| Amyotrophic_Lateral_Scler["Amyotrophic Lateral Sclerosis"]
    USP30["USP30"] -->|"therapeutic target"| Alzheimer["Alzheimer"]
    USP30["USP30"] -->|"activates"| Als["Als"]
    USP30["USP30"] -->|"therapeutic target"| Huntington["Huntington"]
    USP30["USP30"] -->|"therapeutic target"| Ms["Ms"]
    USP30["USP30"] -->|"regulates"| Parkinson["Parkinson"]
    USP30["USP30"] -->|"regulates"| Alzheimer["Alzheimer"]
    USP30["USP30"] -->|"therapeutic target"| Als["Als"]
    USP30["USP30"] -->|"associated with"| Ms["Ms"]
    style USP30 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Aging fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cardiovascular fill:#ef5350,stroke:#333,color:#e0e0e0
    style Parkinson fill:#ef5350,stroke:#333,color:#e0e0e0
    style Amyotrophic_Lateral_Scler fill:#ef5350,stroke:#333,color:#e0e0e0
    style Alzheimer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Huntington fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (88)

Target	Relation	Type	Str
dopaminergic neurons	protects_against	cell_type	1.00
phospho-S129 αSyn	decreases	protein	0.90
Parkinson	regulates	disease	0.75
Parkinson	inhibits	disease	0.75
Mitophagy	activates	pathway	0.70
autophagy pathway	participates_in	pathway	0.70
Als	regulates	disease	0.65
Cardiovascular	activates	disease	0.65
Aging	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Heart Failure	therapeutic_target	disease	0.65
Als	implicated_in	disease	0.65
Cardiac	implicated_in	disease	0.65
ALS	activates	disease	0.65
Alzheimer	activates	disease	0.65
Huntington	activates	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	activates	disease	0.65
Huntington	therapeutic_target	disease	0.65
Parkinson	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Synucleinopathy	inhibits	disease	0.65
Alzheimer	regulates	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	associated_with	disease	0.65
Als	inhibits	disease	0.65
Dopaminergic	activates	cell_type	0.60
T Cell	inhibits	cell_type	0.60
Neuron	inhibits	cell_type	0.60
FOXO3	activates	gene	0.60
HSPD1	activates	gene	0.60
COX4I1	activates	gene	0.60
GRIA2	activates	gene	0.60
PRKN	activates	gene	0.60
OPTN	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
MYO7A	activates	gene	0.60
ATF3	activates	gene	0.60
PINK1	activates	gene	0.60
TOMM20	activates	gene	0.60
PARKIN	activates	gene	0.60
XBP1	activates	gene	0.60
PINK1	associated_with	gene	0.60
MUL1	regulates	gene	0.60
neurodegeneration	activates	disease	0.60
Autophagy	activates	pathway	0.60
Mitophagy	therapeutic_target	pathway	0.60

Incoming (59)

Source	Relation	Type	Str
PINK1	activates	gene	0.70
PARKIN	activates	gene	0.70
PARKINSON'S DISEASE	inhibits	gene	0.70
PARKINSON	inhibits	gene	0.70
PARKINSON'S DISEASE	regulates	gene	0.70
MITOPHAGY	activates	gene	0.70
MITOPHAGY	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.60
ALZHEIMER DISEASE	therapeutic_target	gene	0.60
MITOCHONDRIAL DYSFUNCTION	therapeutic_target	gene	0.60
AUTOPHAGY	regulates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	0.60
PARKIN	regulates	gene	0.60
UBIQUITIN	regulates	gene	0.60
FUS	activates	gene	0.60
CDK5	regulates	gene	0.60
MAVS	regulates	gene	0.60
FBXO7	regulates	gene	0.60
GENES	therapeutic_target	gene	0.60
PINK1	causes	gene	0.60
PARK2	inhibits	gene	0.60
UBIQUITIN	inhibits	gene	0.60
SNCA	inhibits	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
MITOPHAGY	implicated_in	gene	0.60
RNA	associated_with	gene	0.60
RNA	regulates	gene	0.60
RNA	activates	gene	0.60
NEURODEGENERATIVE DISORDERS	regulates	gene	0.60
MITOPHAGY	inhibits	gene	0.60
GENES	inhibits	gene	0.60
MITOPHAGY	therapeutic_target	gene	0.60
AUTOPHAGY	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
OPTN	activates	gene	0.60
XBP1	activates	gene	0.60
ATF3	activates	gene	0.60
TOMM20	activates	gene	0.60
PTEN	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
PRKN	activates	gene	0.60
HSPD1	activates	gene	0.60
FOXO3	activates	gene	0.60
HSP60	activates	gene	0.60
OPTINEURIN	activates	gene	0.60
GRIA2	activates	gene	0.60
COX4I1	activates	gene	0.60
PINK1	regulates	gene	0.60
PINK1	implicated_in	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Mitophagy Induction as Neuroprotective Strategy in Sporadic	0.585	neurodegeneration	Legacy Pre-Pipeline Hypothesis Import

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning USP30 in their description or question text

No additional research found