gene

CEBPB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CEBPB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

212Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

CEBPB is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, regulates. Associated with ALS, Aging, Als. Connected to 167 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CEBPB
Protein Type	Transcription Factor
Function	They function as homo- or heterodimers and regulate gene expression through their leucine zipper DNA-binding domains.
Primary Expression	various tissues including brain, where it plays important roles in:
Pathways	Innate Immunity
UniProt ID	P17676
Ensembl ID	ENSG00000172216
GeneCards	CEBPB
Human Protein Atlas	CEBPB
Glial Cell Function	Regulation of astrocyte and microglial activation
Inflammatory Response	Control of pro-inflammatory cytokine expression
Metabolic Regulation	Modulation of glucose and lipid metabolism
Cell Differentiation	Involvement in cellular differentiation programs
Associated Diseases	Als, Cancer, Carcinoma, Cirrhosis
Interactions	AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AND, ATG5
KG Connections	212 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: CEBPB — AlphaFold P17676 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CEBPB Gene

gene · 567 words

→

Pathway Diagram

graph TD
    CEBPB["CEBPB"]
    CEBPB -->|"regulates"| COMPLEMENT["COMPLEMENT"]
    CEBPB -->|"activates"| Cirrhosis["Cirrhosis"]
    CEBPB -->|"activates"| Carcinoma["Carcinoma"]
    CEBPB -->|"activates"| Ms["Ms"]
    CEBPB -->|"activates"| Als["Als"]
    CEBPB -->|"activates"| Neurodegeneration["Neurodegeneration"]
    CEBPB -->|"activates"| Inflammation["Inflammation"]
    CEBPB -->|"activates"| Neuroinflammation["Neuroinflammation"]
    CEBPB -->|"activates"| Alzheimer["Alzheimer"]
    CEBPB -->|"regulates"| Heart_Failure["Heart Failure"]
    COP1["COP1"] -->|"inhibits"| CEBPB
    EGF["EGF"] -->|"activates"| CEBPB
    CYP3A4["CYP3A4"] -->|"activates"| CEBPB
    PDK1["PDK1"] -->|"activates"| CEBPB
    MTOR["MTOR"] -->|"activates"| CEBPB
    EGFR["EGFR"] -->|"activates"| CEBPB
    ERCC3["ERCC3"] -->|"activates"| CEBPB
    CYP1A2["CYP1A2"] -->|"activates"| CEBPB
    PI3K["PI3K"] -->|"activates"| CEBPB
    AKT["AKT"] -->|"activates"| CEBPB

Outgoing (134)

Target	Relation	Type	Str
COMPLEMENT	regulates	gene	0.85
Hepatocellular Carcinoma	risk_factor_for	disease	0.85
Hepatocellular Carcinoma	contributes_to	disease	0.80
Inflammation	activates	disease	0.75
Als	regulates	disease	0.75
Autophagy	activates	pathway	0.70
oxidative stress response	participates_in	pathway	0.70
Heart Failure	regulates	disease	0.65
Ms	inhibits	disease	0.65
Aging	therapeutic_target	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Hypertension	expressed_in	disease	0.65
Als	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Ischemia	biomarker_for	disease	0.65
Carcinoma	associated_with	disease	0.65
Ms	regulates	disease	0.65
Als	associated_with	disease	0.65
Cirrhosis	associated_with	disease	0.65
Tumor	activates	disease	0.65
Colorectal Cancer	activates	disease	0.65
Cancer	activates	disease	0.65
Alzheimer	activates	disease	0.65
Ms	activates	disease	0.65
Als	activates	disease	0.65
Cirrhosis	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Carcinoma	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
ALS	activates	disease	0.65
Cancer	associated_with	disease	0.65
CYP1A2	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
MICROGLIA	activates	gene	0.60
COMPLEMENT	activates	gene	0.60
Differentiation	activates	pathway	0.60
CANCER	associated_with	gene	0.60
GENES	activates	gene	0.60
TNFAIP3	associated_with	gene	0.60
HSPA1B	associated_with	gene	0.60
HSPA1A	associated_with	gene	0.60
ATG7	activates	gene	0.60
Pi3K	activates	pathway	0.60
Mtor	activates	pathway	0.60
Complement	activates	pathway	0.60
AMPK	activates	gene	0.60
AUTOPHAGY-RELATED GENES	activates	gene	0.60
Mitochondrial Function	activates	pathway	0.60
Oxidative Phosphorylation	activates	pathway	0.60

Incoming (78)

Source	Relation	Type	Str
COP1	inhibits	gene	0.95
AUTOPHAGY	activates	gene	0.70
UBIQUITIN	activates	gene	0.60
TAU	activates	gene	0.60
BNIP3	inhibits	gene	0.60
VDAC1	inhibits	gene	0.60
FUNDC1	inhibits	gene	0.60
TOMM20	inhibits	gene	0.60
TIMM9	inhibits	gene	0.60
TIMM17B	inhibits	gene	0.60
OMA1	inhibits	gene	0.60
TIMM23	inhibits	gene	0.60
MTOR	inhibits	gene	0.60
NRF1	inhibits	gene	0.60
HSPD1	regulates	gene	0.60
MFN2	inhibits	gene	0.60
MFF	inhibits	gene	0.60
BECN1	inhibits	gene	0.60
LONP1	inhibits	gene	0.60
FOS	regulates	gene	0.60
HK2	therapeutic_target	gene	0.60
LGALS3	regulates	gene	0.60
RELA	regulates	gene	0.60
SOD2	regulates	gene	0.60
FGF21	regulates	gene	0.60
DUSP6	regulates	gene	0.60
BMI1	regulates	gene	0.60
GADD45A	associated_with	gene	0.60
JUN	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
HSPA1B	associated_with	gene	0.60
SERPINE1	associated_with	gene	0.60
HSPA1A	associated_with	gene	0.60
TNFAIP3	associated_with	gene	0.60
FOXO1	activates	gene	0.60
CCL20	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
GAPDH	associated_with	gene	0.60
HSP90AA1	associated_with	gene	0.60
GENES	activates	gene	0.60
LC3B	activates	gene	0.60
MICROGLIA	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
COP1	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
COMPLEMENT	activates	gene	0.60
PRO-INFLAMMATORY GENES	activates	gene	0.60
NEUROTOXICITY	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
ATG7	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CEBPB in their description or question text

No additional research found